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Original Article

The Effect of Angiotensin II Receptor Blockade on Insulin Sensitivity and Sympathetic Nervous System Activity in Primary Hypertension

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Pages 185-188 | Received 12 Feb 1993, Accepted 13 Aug 1993, Published online: 08 Jul 2009

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Xiaolu Bao, Weibo Zhu, Yajing Da, Linfeng Zhu, Li Qie, Yijia Yan, Li Wang, Hesheng Tang & Zhi-long Chen. (2015) Synthesis and pharmacological evaluation of a novel AT1 angiotensin II receptor antagonist with anti-hypertension and anti-tumor effects. Clinical and Experimental Hypertension 37:6, pages 490-497.
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Zekeriya Arslan, Seyit Ahmet Ay, Murat Karaman, Mustafa Cakar, Turgay Celik, Sevket Balta, Muharrem Akhan, Hakan Sarlak, Erol Arslan, Seref Demirbas, Sait Demirkol, Fatih Bulucu & Kenan Saglam. (2013) An Additional LDL-Lowering Effect of Amlodipine; Not Only an Antihypertensive?. Clinical and Experimental Hypertension 35:6, pages 449-453.
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S. Oparil, N. Abate, E. Chen, M. A. Creager, V. Galet, G. Jia, S. Julius, A. Lerman, P. A. Lyle, J. Pool & A. M. Tershakovec. (2008) A double-blind, randomized study evaluating losartan potassium monotherapy or in combination with hydrochlorothiazide versus placebo in obese patients with hypertension. Current Medical Research and Opinion 24:4, pages 1101-1114.
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Sverre E Kjeldsen, Paulette A Lyle, Andrew M Tershakovec, Richard B Devereux, Suzanne Oparil, Björn Dahlöf, Ulf de Faire, Frej Fyhrquist, Hans Ibsen, Krister Kristianson, Ole Lederballe-Pedersen, Lars H Lindholm, Markku S Nieminen, Per Omvik & Hans Wedel. (2005) Targeting the renin–angiotensin system for the reduction of cardiovascular outcomes in hypertension: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Expert Opinion on Emerging Drugs 10:4, pages 729-745.
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K. Shimamoto, N. Ura, M. Nakagawa, K. Higashiura, H. Takizawa, Y. Miyazaki, N. Nomura, A. Hirata, Y. Takagawa, H. Murakami & O. Iimura. (1996) The Mechanisms of the Improvement of Insulin Sensitivity by Angiotensin Converting Enzyme Inhibitor. Clinical and Experimental Hypertension 18:2, pages 257-266.
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Deng-Yuan Jian, Yu-Wen Chao, Ching-Heng Ting, Seng-Wong Huang, Chao-Fu Chang, Chi-Chang Juan & Jinn-Yang Chen. (2013) Losartan ameliorates renal injury, hypertension, and adipocytokine imbalance in 5/6 nephrectomized rats. European Journal of Pharmacology 709:1-3, pages 85-92.
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T A Aksnes, H M Reims, S Guptha, A Moan, I Os & S E Kjeldsen. (2006) Improved insulin sensitivity with the angiotensin II-receptor blocker losartan in patients with hypertension and other cardiovascular risk factors. Journal of Human Hypertension 20:11, pages 860-866.
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Mark E Cooper, Chris Tikellis & Merlin C Thomas. (2006) Preventing diabetes in patients with hypertension: one more reason to block the renin–angiotensin system. Journal of Hypertension 24:Suppl 1, pages S57-S63.
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Licio A. Velloso, Franco Folli, Lucia Perego & Mario J. A. Saad. (2006) The multi-faceted cross-talk between the insulin and angiotensin II signaling systems. Diabetes/Metabolism Research and Reviews 22:2, pages 98-107.
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Salvatore Di Somma & Alberto Sentimentale. (2006) New Onset of Type 2 Diabetes Mellitus during Antihypertensive Therapy. High Blood Pressure & Cardiovascular Prevention 13:1, pages 29-36.
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AJ Scheen. (2004) Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Diabetes & Metabolism 30:6, pages 498-505.
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Raymond R. Townsend. (2003) Angiotensin and insulin resistance: Conspiracy theory. Current Hypertension Reports 5:2, pages 110-116.
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Elena Bernobich, Luisa de Angelis, Carlos Lerin & Giuseppe Bellini. (2002) The Role of the Angiotensin System in Cardiac Glucose Homeostasis. Drugs 62:9, pages 1295-1314.
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S. Nielsen, K. Y. Hove, J. Dollerup, P. L. Poulsen, J. S. Christiansen, O. Schmitz & C. E. Mogensen. (2001) Losartan modifies glomerular hyperfiltration and insulin sensitivity in type 1 diabetes. Diabetes, Obesity and Metabolism 3:6, pages 463-471.
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Chris M Terpening. (2016) Mediators of Chronic Heart Failure: How Drugs Work. Annals of Pharmacotherapy 35:9, pages 1066-1074.
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M HanefeldC Abletshauser. (2016) Effect of the Angiotensin II Receptor Antagonist Valsartan on Lipid Profile and Glucose Metabolism in Patients with Hypertension. Journal of International Medical Research 29:4, pages 270-279.
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Arya M. Sharma, Tobias Pischon, Stefan Engeli & Juergen Scholze. (2001) Choice of drug treatment for obesity-related hypertension: where is the evidence?. Journal of Hypertension 19:4, pages 667-674.
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K. Higashiura, N. Ura, T. Takada, Y. Li, T. Torii, N. Togashi, M. Takada, H. Takizawa & K. Shimamoto. (2000) The effects of an angiotensin-converting enzyme inhibitor and an angiotensin II receptor antagonist on insulin resistance in fructose-fed rats. American Journal of Hypertension 13:3, pages 290-297.
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M. Frossard, Ch. Joukhadar, G. Steffen, R. Schmid, H.G. Eichler & M. Müller. (2000) Paracrine effects of angiotensin-converting-enzyme- and angiotensin-II-receptor-inhibition on transcapillary glucose transport in humans. Life Sciences 66:10, pages PL147-PL154.
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Nobuyuki Ura, Katsuhiro Higashiura & Kazuaki Shimamoto. (1999) The mechanisms of insulin sensitivity improving effects of angiotensin converting enzyme inhibitor. Immunopharmacology 44:1-2, pages 153-159.
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Nasser Mikhail, Michael S. Golub & Michael L. Tuck. (1999) Obesity and hypertension. Progress in Cardiovascular Diseases 42:1, pages 39-58.
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J. Schrader & S. Lüders. 1999. Angiotensin II AT1-Rezeptorantagonisten. Angiotensin II AT1-Rezeptorantagonisten 145 178 .
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András Mogyorósi & Sándor Sonkodi. (1999) AT1 receptor antagonists: a challenge for ACE inhibitors in diabetic nephropathy. Diabetes/Metabolism Research and Reviews 15:1, pages 55-58.
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AC Leary & TM MacDonald. (1998) ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKADE: A NEW DEVELOPMENT IN CARDIOVASCULAR PHARMACOLOGY. International Journal of Clinical Practice 52:7, pages 475-481.
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M. Lerch, A. U. Teuscher, P. Beissner, M. Schneider, S. G. Shaw & P. Weidmann. (1998) Effects of Angiotensin II-Receptor Blockade with Losartan on Insulin Sensitivity, Lipid Profile, and Endothelin in Normotensive Offspring of Hypertensive Parents. Journal of Cardiovascular Pharmacology 31:4, pages 576-580.
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Roberto Giovannetti, Claudia Del Corso, Francesco Galeone, Franco Giuntoli & Paolo Saba. (1997) Efficacy and safety of losartan in hypertensive patients with side effects induced by other antihypertensive agents. Current Therapeutic Research 58:11, pages 851-858.
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Hitomi Yokoyama, Shinya Minatoguchi, Masatoshi Koshiji, Yoshihiro Uno, Masao Kakami, Chisato Nagata, Hiroyasu Ito & Hisayoshi Fujiwara. (1997) LOSARTAN AND CAPTOPRIL FOLLOW DIFFERENT MECHANISMS TO DECREASE PRESSOR RESPONSES IN THE PITHED RAT. Clinical and Experimental Pharmacology and Physiology 24:9-10, pages 697-705.
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Talma RosenthalYael ErlichEliezer RosenmannAharon Cohen. (1997) Effects of Enalapril, Losartan, and Verapamil on Blood Pressure and Glucose Metabolism in the Cohen-Rosenthal Diabetic Hypertensive Rat. Hypertension 29:6, pages 1260-1264.
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Larry Chow, Marc De Gasparo & Nigel Levens. (1997) Blockade of angiotensin converting enzyme but not of angiotensin AT1 receptors improves glucose tolerance. European Journal of Pharmacology 319:1, pages 77-83.
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