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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 17, 1988 - Issue 5
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Original Article

The Significance of Natural Autoantibodies

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Pages 389-424 | Published online: 07 Jul 2009

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Read on this site (6)

John A. Mcintyre, Dawn R. Wagenknecht & Curtis J. Ramsey. (2009) Redox-reactive antiphospholipid antibody differences between serum from Alzheimer's patients and age-matched controls. Autoimmunity 42:8, pages 646-652.
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John A. McIntyre, Joab Chapman, Efrat Shavit, Ronald L. Hamilton & Steven T. DeKosky. (2007) Redox-reactive autoantibodies in Alzheimer's patients' cerebrospinal fluids: Preliminary studies. Autoimmunity 40:5, pages 390-396.
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KennethL. Hastings. (2006) Risk Assessment in Drug Development: Autoimmunity. Journal of Toxicology and Environmental Health, Part A 69:9, pages 893-898.
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Yoshiaki Ishigatsubo, Alfred D. Steinberg, Arthur Krieg & Dennis M. Klinman. (1995) Increased Utilization of Polyreactive B Cells During Periods of Generalized Immune Activation. Autoimmunity 22:2, pages 113-119.
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B. Gilburd, M. Stein, Y. Tomer, D. Tanne, O. Abramski, Y. Chapman, A. Ahiron, M. Blank & Y. Shoenfeld. (1993) Autoantibodies to Phospholipids and Brain Extract in Patients with the Guillain-Barre Syndrome: Cross-Reactive or Pathogenic?. Autoimmunity 16:1, pages 23-27.
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Rick Hoekzema, Siong B. Hwan, Aniki Rothova, Mariette A.C. van Haren, Larry A. Donoso & Aize Kijlstra. (1990) Serum antibody response to human and bovine IRBP in uveitis. Current Eye Research 9:12, pages 1177-1183.
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Articles from other publishers (73)

M Rifqi Ismiraj, Joop A.J. Arts & Henk K. Parmentier. (2019) Maternal Transfer of Natural (Auto-) Antibodies in Chickens. Poultry Science 98:6, pages 2380-2391.
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S. Cecchini, D. Rufrano & A.R. Caputo. (2019) Natural antibodies and their relationship with total immunoglobulins and acquired antibody response in goat kid (Capra hircus, L. 1758) serum. Veterinary Immunology and Immunopathology 211, pages 38-43.
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Stefan Landmann, Nicolas Preuss & Ulrich Behn. (2017) Self-tolerance and autoimmunity in a minimal model of the idiotypic network. Journal of Theoretical Biology 426, pages 17-39.
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P.E. Boucher. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 445 476 .
Olga A. SmirnovaOlga A. Smirnova. 2017. Environmental Radiation Effects on Mammals. Environmental Radiation Effects on Mammals 141 159 .
Stefano Cecchini, Michele Rossetti, Francesco Di Tomaso & Anna Rocchina Caputo. (2016) Evaluation of the effects of dexamethasone-induced stress on levels of natural antibodies in immunized laying hens. Veterinary Immunology and Immunopathology 177, pages 35-41.
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T. V. L. Berghof, S. A. S. van der Klein, J. A. J. Arts, H. K. Parmentier, J. J. van der Poel & H. Bovenhuis. (2015) Genetic and Non-Genetic Inheritance of Natural Antibodies Binding Keyhole Limpet Hemocyanin in a Purebred Layer Chicken Line. PLOS ONE 10:6, pages e0131088.
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S.A.S. van der Klein, T.V.L. Berghof, J.A.J. Arts, H.K. Parmentier, J.J. van der Poel & H. Bovenhuis. (2015) Genetic relations between natural antibodies binding keyhole limpet hemocyanin and production traits in a purebred layer chicken line. Poultry Science 94:5, pages 875-882.
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N. Mayasari, G. de Vries Reilingh, M.G.B. Nieuwland, G.J. Remmelink, H.K. Parmentier, B. Kemp & A.T.M. van Knegsel. (2015) Effect of maternal dry period length on colostrum immunoglobulin content and natural and specific antibody titers in calves. Journal of Dairy Science.
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Sara Salehi Hammerstad, Ronald Villanueva & Yaron Tomer. 2015. Infection and Autoimmunity. Infection and Autoimmunity 891 918 .
Zhao-hua Zhou, Teresa Wild, Ying Xiong, Laine H. Sylvers, Yahong Zhang, Luxia Zhang, Larry Wahl, Sharon M. Wahl, Steven Kozlowski & Abner L. Notkins. (2013) Polyreactive Antibodies Plus Complement Enhance the Phagocytosis of Cells Made Apoptotic by UV-Light or HIV. Scientific Reports 3:1.
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Francis S. Balucan, Syed A. Morshed & Terry F. Davies. (2013) Thyroid Autoantibodies in Pregnancy: Their Role, Regulation and Clinical Relevance. Journal of Thyroid Research 2013, pages 1-15.
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Norbert Gleicher, Andrea Weghofer & David H. Barad. (2012) Cutting edge assessment of the impact of autoimmunity on female reproductive success. Journal of Autoimmunity 38:2-3, pages J74-J80.
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Olga Moiseeva, Lubov Mitrofanova, Elena Karelkina, Dmitry Zverev, Dmitry Lebedev, Serge Skurydin & Alexander Poletaev. (2012) Serological diagnostics of myocardium diseases based on multivariate analysis of cardiotrophic autoantibodies’ profiles. Open Journal of Immunology 02:01, pages 49-58.
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Liliane M. Cunha, Paulo L. Bittencourt, Clarice P. Abrantes-Lemos, Agnaluce Moreira, Delvone Almeida, Raymundo Parana & Zilton Andrade. (2012) Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study. Human Immunology 73:1, pages 70-74.
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T.C.W. Ploegaert, E. Tijhaar, T.J.G.M. Lam, A. Taverne-Thiele, J.J. van der Poel, J.A.M. van Arendonk, H.F.J. Savelkoul & H.K. Parmentier. (2011) Natural antibodies in bovine milk and blood plasma: Variability among cows, repeatability within cows, and relation between milk and plasma titers. Veterinary Immunology and Immunopathology 144:1-2, pages 88-94.
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Y. Sun, H.K. Parmentier, K. Frankena & J.J. van der Poel. (2011) Natural antibody isotypes as predictors of survival in laying hens. Poultry Science 90:10, pages 2263-2274.
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T.C.W. Ploegaert, S. Wijga, E. Tijhaar, J.J. van der Poel, T.J.G.M. Lam, H.F.J. Savelkoul, H.K. Parmentier & J.A.M. van Arendonk. (2010) Genetic variation of natural antibodies in milk of Dutch Holstein-Friesian cows. Journal of Dairy Science 93:11, pages 5467-5473.
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T.V.L. Berghof, G. De Vries Reilingh, M.G.B. Nieuwland & H.K. Parmentier. (2010) Effect of aging and repeated intratracheal challenge on levels of cryptic and overt natural antibodies in poultry. Poultry Science 89:2, pages 227-235.
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Olga A. SmirnovaOlga A. Smirnova. 2010. Environmental Radiation Effects on Mammals. Environmental Radiation Effects on Mammals 151 169 .
Cristiano Alessandri, Fabrizio Conti, Paola Conigliaro, Riccardo Mancini, Laura Massaro & Guido Valesini. (2009) Seronegative Autoimmune Diseases. Annals of the New York Academy of Sciences 1173:1, pages 52-59.
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John A. McIntyre & W. Page Faulk. (2008) Redox-Reactive Autoantibodies: Biochemistry, Characterization, and Specificities. Clinical Reviews in Allergy & Immunology 37:1, pages 49-54.
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R Finnern, J M Bye, K M Dolman, M-H Zhao, A Short, J D Marks, M C LOCK Wood & W H Ouwehand. (1995) Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries. Clinical and Experimental Immunology 102:3, pages 566-574.
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C VERHAGEN, A C BREEBAART, M S A SUTTORP-SCHULTEN, R HOEKZEMA, M VAN HAREN & A KIJLSTRA. (1992) Induction of autoantibodies to rat corneal protein 54. Clinical and Experimental Immunology 88:1, pages 101-106.
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H.K. Parmentier, G. De Vries Reilingh & A. Lammers. (2008) Decreased Specific Antibody Responses to α-Gal-Conjugated Antigen in Animals with Preexisting High Levels of Natural Antibodies Binding α-Gal Residues. Poultry Science 87:5, pages 918-926.
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Albert J Czaja. (2008) Clinical Features, Differential Diagnosis and Treatment of Autoimmune Hepatitis in the Elderly. Drugs & Aging 25:3, pages 219-239.
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A.T.M. van Knegsel, G. de Vries Reilingh, S. Meulenberg, H. van den Brand, J. Dijkstra, B. Kemp & H.K. Parmentier. (2007) Natural Antibodies Related to Energy Balance in Early Lactation Dairy Cows. Journal of Dairy Science 90:12, pages 5490-5498.
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Norbert Gleicher, David Barad & Andrea Weghofer. (2007) Functional autoantibodies, a new paradigm in autoimmunity?. Autoimmunity Reviews 7:1, pages 42-45.
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B. Ask, E.H. van der Waaij, E.J. Glass & S.C. Bishop. (2007) Modeling Immunocompetence Development and Immunoresponsiveness to Challenge in Chicks. Poultry Science 86:7, pages 1336-1350.
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Meng Fu, Ping-shen Fan, Wei Li, Cheng-xin Li, Ying Xing, Jing-gang An, Gang Wang, Xue-li Fan, Tian-wen Gao, Yu-feng Liu & Shigaku Ikeda. (2006) Identification of poly-reactive natural IgM antibody that recognizes late apoptotic cells and promotes phagocytosis of the cells. Apoptosis 12:2, pages 355-362.
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Maria Siwek, Bart Buitenhuis, Sandra Cornelissen, Mike Nieuwland, Egbert F. Knol, Richard Crooijmans, Martien Groenen, Henk Parmentier & Jan van der Poel. (2006) Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens. Developmental & Comparative Immunology 30:7, pages 659-666.
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John A. McIntyre, Dawn R. Wagenknecht & W. Page Faulk. (2006) Redox-reactive autoantibodies: Detection and physiological relevance. Autoimmunity Reviews 5:1, pages 76-83.
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. 2004. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology 55 126 .
Aart Lammers, Marcel E.V. Klomp, Mike G.B. Nieuwland, Huub F.J. Savelkoul & Henk K. Parmentier. (2004) Adoptive transfer of natural antibodies to non-immunized chickens affects subsequent antigen-specific humoral and cellular immune responses. Developmental & Comparative Immunology 28:1, pages 51-60.
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Henk K Parmentier, Aart Lammers, Jan J Hoekman, Ger De Vries Reilingh, Ilja T.A Zaanen & Huub F.J Savelkoul. (2004) Different levels of natural antibodies in chickens divergently selected for specific antibody responses. Developmental & Comparative Immunology 28:1, pages 39-49.
Crossref
Yaron Tomer & Ronald Villanueva. 2004. Infection and Autoimmunity. Infection and Autoimmunity 515 530 .
Albert J. Czaja & Gary L. Norman. (2003) Autoantibodies in the Diagnosis and Management of Liver Disease. Journal of Clinical Gastroenterology 37:4, pages 315-329.
Crossref
Russell R. Reid, Sean Woodcock, Alexander Shimabukuro-Vornhagen, William G. AustenJr.Jr., Lester Kobzik, Ming Zhang, Herbert B. Hechtman, Francis D. MooreJr.Jr. & Michael C. Carroll. (2002) Functional Activity of Natural Antibody is Altered in Cr2-Deficient Mice. The Journal of Immunology 169:10, pages 5433-5440.
Crossref
Albert J. Czaja & Henry A. Homburger. (2001) Autoantibodies in liver disease. Gastroenterology 120:1, pages 239-249.
Crossref
Jacques Descotes. (2000) Autoimmunity and toxicity testing. Toxicology Letters 112-113, pages 461-465.
Crossref
Albert J Czaja. (1999) Behavior and significance of autoantibodies in type 1 autoimmune hepatitis. Journal of Hepatology 30:3, pages 394-401.
Crossref
M Geffard, D Bodet, P Cloudepierre, JM Metzger & J Sibilia. (1998) Anticorps sériques circulants dirigés contre des antigènes modifiés par le NO dans les affections neurologiques et rhumatismales. Immuno-analyse & Biologie Spécialisée 13:4, pages 209-217.
Crossref
Stratis Avrameas & Thérèse Ternynck. 1998. Encyclopedia of Immunology. Encyclopedia of Immunology 1806 1809 .
Stefanie S. Bussen & Thomas Steck. (1997) Thyroid antibodies and their relation to antithrombin antibodies, anticardiolipin antibodies and lupus anticoagulant in women with recurrent spontaneous abortions (antithyroid, anticardiolipin and antithrombin autoantibodies and lupus anticoagulant in habitual aborters). European Journal of Obstetrics & Gynecology and Reproductive Biology 74:2, pages 139-143.
Crossref
P.J. Cooper, R.H. Guderian, R. Proaño & D.W. Taylor. (1997) The pathogenesis of chorioretinal disease in onchocerciasis. Parasitology Today 13:3, pages 94-98.
Crossref
Yaron Tomer. 1997. Idiotypes in Medicine: Autoimmunity, Infection and Cancer. Idiotypes in Medicine: Autoimmunity, Infection and Cancer 157 163 .
PhilipJ Cooper. (1996) Autoimmunity and onchocerciasis. The Lancet 347:8998, pages 404.
Crossref
Albert J. Czaja. (1995) 5 Autoantibodies. Baillière's Clinical Gastroenterology 9:4, pages 723-744.
Crossref
Y. Shoenfeld, A. Beresovski, D. Zharhary, Y. Tomer, M. Swissa, E. Sela, A. Zimran, S. Zevin, B. Gilburd & M. Blank. (1995) Natural autoantibodies in sera of patients with Gaucher's disease. Journal of Clinical Immunology 15:6, pages 363-372.
Crossref
Nicola Bizzaro. (2006) EDTA‐dependent pseudothrombocytopenia: A clinical and epidemiological study of 112 cases, with 10‐year follow‐up. American Journal of Hematology 50:2, pages 103-109.
Crossref
Sébastien Lacroix‐Desmazes, Luc Mouthon, Antonio Coutinho & Michel D. Kazatchkine. (2005) Analysis of the natural human IgG antibody repertoire: life‐long stability of reactivities towards self antigens contrasts with age‐dependent diversification of reactivities against bacterial antigens. European Journal of Immunology 25:9, pages 2598-2604.
Crossref
S. Avrameas & T. Ternynck. (1995) Natural autoantibodies: The other side of the immune system. Research in Immunology 146:4-5, pages 235-248.
Crossref
T. G. Paglieroni, J. Ward & P. V. Holland. (2003) Changes in peripheral blood CD5 (Bla) B‐cell populations and autoantibodies following blood transfusion. Transfusion 35:3, pages 189-198.
Crossref
Albert J. Czaja. (1995) Autoimmune hepatitis. Digestive Diseases and Sciences 40:2, pages 435-456.
Crossref
Maja Hojnik, Boris Gilburd, Lea Ziporen, Miri Blank, Yaron Tomer, Morton A. Scheinberg, Angela Tincani, Blaz Rozman & Yehuda Shoenfeld. (2016) Anticardiolipin Antibodies in Infections are Heterogenous in Their Dependency on β 2-Glycoprotein I: Analysis of Anticardiolipin Antibodies in Leprosy. Lupus 3:6, pages 515-521.
Crossref
Donna E. Pratt. (1994) THYROID ANTIBODIES. Immunology and Allergy Clinics of North America 14:4, pages 835-838.
Crossref
Dennis M. Klinman. 1994. Handbook of B and T Lymphocytes. Handbook of B and T Lymphocytes 473 490 .
Stratis Avrameas & Thérèse Ternynck. (1993) The natural autoantibodies system: Between hypotheses and facts. Molecular Immunology 30:12, pages 1133-1142.
Crossref
G. Tchernia, M. C. Morel‐Kopp, J. Yvart & C. Kaplan. (2008) Neonatal thrombocytopenia and hidden maternal autoimmunity. British Journal of Haematology 84:3, pages 457-463.
Crossref
Donna Pratt, Marilyn Novotny, George Kaberlein, Alan Dudkiewicz & Norbert Gleicher. (1993) Antithyroid antibodies and the association with non-organ-specific antibodies in recurrent pregnancy loss. American Journal of Obstetrics and Gynecology 168:3, pages 837-841.
Crossref
Yehuda Shoenfeld. (1993) Pathogenic natural autoantibodies. Clinical Immunology Newsletter 13:2-3, pages 13-19.
Crossref
David Saphier. 1993. Hormonally Induced Changes to the Mind and Brain. Hormonally Induced Changes to the Mind and Brain 191 224 .
Hans U. Lutz. (1992) Naturally Occurring Anti-Band 3 Antibodies. Transfusion Medicine Reviews 6:3, pages 201-211.
Crossref
I. Krause, J. Cohen, M. Blank, R. Bakimer, A. Cartman, A. Hohmann, G. Valesini, R.A. Asherson, M.A. Khamashta, G.R.V. Hughes & Y. Shoenfeld. (2016) Distribution of Two Common Idiotypes of Anticardiolipin Antibodies in Sera of Patients with Primary Antiphospholipid Syndrome, Systemic Lupus Erythematosus and Monoclonal Gammopathies. Lupus 1:2, pages 91-96.
Crossref
. (1992) Review. Clinical Chemistry and Laboratory Medicine 30:12.
Crossref
Majida Bouanani, Regis Bataille, Martine Piechaczyk, Sharon Lynn Salhi, Bernard Pau & Madeleine Bastide. (2010) Autoimmunity to human thyroglobulin: Respective epitopic specificity patterns of anti‐human thyroglobulin autoantibodies in patients with sjögren's syndrome and patients with hashimoto's thyroiditis. Arthritis & Rheumatism 34:12, pages 1585-1593.
Crossref
M. Blank, M. Ben-Bassat & Y. Shoenfeld. (1991) Modulation of SLE induction in naive mice by specific T cells with suppressor activity to pathogenic anti-DNA idiotype. Cellular Immunology 137:2, pages 474-486.
Crossref
BENJAMIN PIURA, ERNEST TAUBER, YAARA DROR, BATIA SAROV, DAN BUSKILA, HANOCH SLOR & YEHUDA SHOENFELD. (2013) Antinuclear Autoantibodies in Healthy Nonpregnant and Pregnant Women and Their Offspring. American Journal of Reproductive Immunology 26:1, pages 28-31.
Crossref
A. M. Poverennyi, R. A. Belovolova, V. A. Kiseleva & A. P. Shinkarkina. (1991) Development of traumatic shock accompanied by increased activity of polyspecific antibodies reacting with DNA and endotoxins. Bulletin of Experimental Biology and Medicine 111:5, pages 704-706.
Crossref
S. Avrameas. (1991) Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’. Immunology Today 12:5, pages 154-159.
Crossref
M. Piechaczyk, M. Bouanani, S.L. Salhi, J.-M. Bastide, M. Bastide & B. Pau. (1990) Epitopic specificities of anti-thyroglobulin autoantibodies. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 17:7, pages 719-722.
Crossref
E. Sigurdsson & S. Bækkeskov. 1990. Human Diabetes. Human Diabetes 143 168 .
Yaron Tomer & Yehuda Shoenfeld. (1989) The significance of T suppressor cells in the development of autoimmunity. Journal of Autoimmunity 2:6, pages 739-758.
Crossref

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