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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 24, 1995 - Issue 3
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Original Article

Analysis of Perforin Expression in Human Peripheral Blood Lymphocytes, CD 56+ Natural Killer Cell Subsets and Its Induction by Interleukin-2

Gordana Konjevic Microbiology and Immunology, University of Miami, School of Medicine, P.O. Box 016960 (R-138), Miami, Florida, 33101, US
,
Barbara Schlesinger Microbiology and Immunology, University of Miami, School of Medicine, P.O. Box 016960 (R-138), Miami, Florida, 33101, US
,
Lirong Cheng Microbiology and Immunology, University of Miami, School of Medicine, P.O. Box 016960 (R-138), Miami, Florida, 33101, US
,
Kristin J. Olsen Microbiology and Immunology, University of Miami, School of Medicine, P.O. Box 016960 (R-138), Miami, Florida, 33101, US
,
Eckhard R. Podack Microbiology and Immunology, University of Miami, School of Medicine, P.O. Box 016960 (R-138), Miami, Florida, 33101, US
&
Ivan Spuzic Institute of Oncology and Radiology, Pasterova, 14, 11000, Beograd, Yugoslavia
Pages 499-507 | Published online: 07 Jul 2009

Citations (37)

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Esin Aktas, Gaye Erten, Umut Can Kucuksezer & Gunnur Deniz. (2009) Natural killer cells: versatile roles in autoimmune and infectious diseases. Expert Review of Clinical Immunology 5:4, pages 405-420.
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Articles from other publishers (36)

Hai-Yan Wang, Xiong-Wei Cui, Yong-Hong Zhang, Yu Chen, Ning-Ning Lu, Li Bai & Zhong-Ping Duan. (2023) Dynamic changes of phenotype and function of natural killer cells in peripheral blood before and after thermal ablation of hepatitis B associated hepatocellular carcinoma and their correlation with tumor recurrence. BMC Cancer 23:1.
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Carmen Maldonado-Bernal & David Sánchez-Herrera. 2020. Toll-like Receptors. Toll-like Receptors.
Vladimir Jurišić, Ana Vuletić, Katarina Mirjačić Martinović & Gordana Konjević. 2020. Cancer Immunology. Cancer Immunology 133 146 .
Chandrima Sinha & Lea C. Cunningham. (2016) An overview of the potential strategies for NK cell-based immunotherapy for acute myeloid leukemia. Pediatric Blood & Cancer 63:12, pages 2078-2085.
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Gordana Konjević, Ana Vuletić & Katarina Mirjačić Martinović. (2015) Natural killer cell receptors: alterations and therapeutic targeting in malignancies. Immunologic Research 64:1, pages 25-35.
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V. Mesdag, M. Salzet & D. Vinatier. (2014) Le trophoblaste?: chef d?orchestre de la tol?rance immunologique maternelle. Journal de Gyn?cologie Obst?trique et Biologie de la Reproduction 43:9, pages 657-670.
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Maureen W. Groer, Nagwa El-Badri, Julie Djeu, S. Nicole Williams, Bradley Kane & Karoly Szekeres. (2013) Suppression of Natural Killer Cell Cytotoxicity in Postpartum Women. Biological Research For Nursing 16:3, pages 320-326.
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Foteini Gogali, George Paterakis, George Z. Rassidakis, Chrysoula I. Liakou & Charis Liapi. (2013) CD3 − CD16 − CD56 bright Immunoregulatory NK Cells are Increased in the Tumor Microenvironment and Inversely Correlate with Advanced Stages in Patients with Papillary Thyroid Cancer . Thyroid 23:12, pages 1561-1568.
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Gordana Konjevic, Vladimir Jurisic, Viktor Jovic, Ana Vuletic, Katarina Mirjacic Martinovic, Sandra Radenkovic & Ivan Spuzic. (2012) Investigation of NK cell function and their modulation in different malignancies. Immunologic Research 52:1-2, pages 139-156.
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G. Konjevi?K. Mirja?i? Martinovi?A. Vuleti?S. Radenkovi?. (2010) Novel aspects of in vitro IL-2 or IFN-? enhanced NK cytotoxicity of healthy individuals based on NKG2D and CD161 NK cell receptor induction. Biomedicine & Pharmacotherapy 64:10, pages 663-671.
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Gordana Konjević, Katarina Mirjačić Martinović, Ana Vuletić, Vladimir Jurisić & Ivan Spužić. (2009) Distribution of Several Activating and Inhibitory Receptors on CD3−CD16+ NK Cells and Their Correlation with NK Cell Function in Healthy Individuals. Journal of Membrane Biology 230:3, pages 113-123.
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Gordana Konjevic. (2009) STAT proteins in cancerogenesis and therapy of malignancies. Srpski arhiv za celokupno lekarstvo 137:1-2, pages 98-105.
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Astrid Schulze, Holger Schirutschke, Uta Oelschlägel, Marc Schmitz, Monika Füssel, Ralf Wassmuth, Gerhard Ehninger, Martin Bornhäuser & Uwe Platzbecker. (2008) Altered phenotype of natural killer cell subsets after haploidentical stem cell transplantation. Experimental Hematology 36:4, pages 378-389.
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G. Konjević, V. Jović, A. Vuletić, S. Radulović, S. Jelić & I. Spužić. (2007) CD69 on CD56+ NK cells and response to chemoimmunotherapy in metastatic melanoma. European Journal of Clinical Investigation 37:11, pages 887-896.
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Aharon G. Freud & Michael A. Caligiuri. (2006) Human natural killer cell development. Immunological Reviews 214:1, pages 56-72.
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Tobias G. Poehlmann, Andreas Schaumann, Susann Busch, Justine S. Fitzgerald, Marise Aguerre-Girr, Philippe Le Bouteiller, Ekkehard Schleussner & Udo R. Markert. (2006) Inhibition of term decidual NK cell cytotoxicity by soluble HLA-G1. American Journal of Reproductive Immunology 56:5-6, pages 275-285.
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William H.D. Hallett & William J. Murphy. (2006) Positive and negative regulation of Natural Killer cells: Therapeutic implications. Seminars in Cancer Biology 16:5, pages 367-382.
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G. Batoni, S. Esin, F. Favilli, M. Pardini, D. Bottai, G. Maisetta, W. Florio & M. Campa. (2005) Human CD56bright and CD56dim Natural Killer Cell Subsets Respond Differentially to Direct Stimulation with Mycobacterium bovis Bacillus Calmette-Guerin. Scandinavian Journal of Immunology 62:6, pages 498-506.
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F. C. S. Aranha, U. Ribeiro, P. Basse, C. E. P. Corbett & M. D. Laurenti. (2005) Interleukin-2-Activated Natural Killer Cells May Have a Direct Role in the Control of Leishmania (Leishmania) amazonensis Promastigote and Macrophage Infection.. Scandinavian Journal of Immunology 62:4, pages 334-341.
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Jill M. Manske & Summer E. Hanson. (2005) Substance-P-Mediated Immunomodulation of Tumor Growth in a Murine Model. Neuroimmunomodulation 12:4, pages 201-210.
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Clemens Feistritzer, Johannes Clausen, Daniel H. Sturn, Angela Djanani, Eberhard Gunsilius, Christian J. Wiedermann & Christian M. K?hler. (2003) Natural killer cell functions mediated by the neuropeptide substance P. Regulatory Peptides 116:1-3, pages 119-126.
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M. P. MILES, L. T. MACKINNON, D. S. GROVE, N. I. WILLIAMS, J. A. BUSH, J. O. MARX, W. J. KRAEMER & A. M. MASTRO. (2002) The relationship of natural killer cell counts, perforin mRNA and CD2 expression to post‐exercise natural killer cell activity in humans. Acta Physiologica Scandinavica 174:4, pages 317-325.
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R Staats, S Balkow, S Sorichter, H Northoff, H Matthys, W Luttmann, A BergJ C Virchow. (2000) Change in perforin-positive peripheral blood lymphocyte (PBL) subpopulations following exercise. Clinical and Experimental Immunology 120:3, pages 434-439.
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Simona Neri, Erminia Mariani, Alessandra Meneghetti, Luca Cattini & Andrea Facchini. (2001) Calcein-Acetyoxymethyl Cytotoxicity Assay: Standardization of a Method Allowing Additional Analyses on Recovered Effector Cells and Supernatants. Clinical Diagnostic Laboratory Immunology 8:6, pages 1131-1135.
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Megan A Cooper, Todd A Fehniger & Michael A Caligiuri. (2001) The biology of human natural killer-cell subsets. Trends in Immunology 22:11, pages 633-640.
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William E. Carson, Robin Parihar, Matthew J. Lindemann, Nicola Personeni, Julie Dierksheide, Neal J. Meropol, Jose Baselga & Michael A. Caligiuri. (2001) Interleukin-2 enhances the natural killer cell response to Herceptin-coated Her2 /neu-positive breast cancer cells. European Journal of Immunology 31:10, pages 3016-3025.
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Ying Yu, Masao Hagihara, Kiyoshi Ando, Balgansuren Gansuvd, Hideyuki Matsuzawa, Takahide Tsuchiya, Yoko Ueda, Hiroyasu Inoue, Tomomitsu Hotta & Shunichi Kato. (2001) Enhancement of Human Cord Blood CD34+ Cell-Derived NK Cell Cytotoxicity by Dendritic Cells. The Journal of Immunology 166:3, pages 1590-1600.
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Ellen Kauschke, Kazuo Komiyama, Itaru Moro, Ines Eue, Simone König & Edwin L. Cooper. (2001) Evidence for perforin-like activity associated with earthworm leukocytes. Zoology 104:1, pages 13-24.
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Jyothi & Khar. (2000) Interleukin-2-Induced Nitric Oxide Synthase and Nuclear Factor-kappaB Activity in Activated Natural Killer Cells and the Production of Interferon-gamma. Scandinavian Journal of Immunology 52:2, pages 148-155.
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VERENA ARNOLD, SANDRA BALKOW, RICHARD STAATS, HEINRICH MATTHYS, WERNER LUTTMANN & JOHANN CHRISTIAN VIRCHOWJr.Jr.. (2000) Increase in Perforin-positive Peripheral Blood Lymphocytes in Extrinsic and Intrinsic Asthma. American Journal of Respiratory and Critical Care Medicine 161:1, pages 182-186.
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Jean-Pierre Aubry, Aline Blaecke, Sybille Lecoanet-Henchoz, Pascale Jeannin, Nathalie Herbault, Gersende Caron, Val�ry Moine & Jean-Yves Bonnefoy. (1999) Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. Cytometry 37:3, pages 197-204.
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M. Grazia CifoneSimona D’AlòRaffaella ParroniDanilo MillimaggiLeda BiordiStefano MartinottiAngela Santoni. (1999) Interleukin-2–Activated Rat Natural Killer Cells Express Inducible Nitric Oxide Synthase That Contributes to Cytotoxic Function and Interferon-γ Production. Blood 93:11, pages 3876-3884.
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Vladimir Jurišić, Ivan Spužić & Gordana Konjević. (1999) A comparison of the NK cell cytotoxicity with effects of TNF-α against K-562 cells, determined by LDH release assay. Cancer Letters 138:1-2, pages 67-72.
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Gordana Konjević, Vladimir Jurišić, Božidar Banićević & Ivan Spužić. (2005) The difference in NK‐cell activity between patients with non‐Hodgkin's lymphomas and Hodgkin's disease. British Journal of Haematology 104:1, pages 144-151.
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Sergio Rutella, Carlo Rumi, M.Barbara Lucia, Benedict Etuk, Roberto Cauda & Giuseppe Leone. (1998) Flow cytometric detection of perforin in normal human lymphocyte subpopulations defined by expression of activation/differentiation antigens. Immunology Letters 60:1, pages 51-55.
Crossref
Gideon Berke. (1997) The Fas-Based Mechanism of Lymphocytotoxicity. Human Immunology 54:1, pages 1-7.
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