106
Views
52
CrossRef citations to date
0
Altmetric
Original Article

Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator

&
Pages 587-618 | Published online: 10 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Ahmed Rabiee, Mohamed Salman, Mohamed Tourky, Mahmoud Ameen, Ahmed Hussein, Ahmed Salman, Safa Labib, Ahmed Abdulkader Zaki Ali Soliman, Hossam El-Din Shaaban, Ghada GabAllah & Tarek Abouelregal. (2021) Antithyroid Peroxidase Antibodies and Histopathological Outcomes in Egyptian Patients Subjected to Total Thyroidectomy for Non-Malignant Nodular Goiter. International Journal of General Medicine 14, pages 2421-2425.
Read now
Takashi Akamizu. (2003) Monoclonal Antibodies to Thyroid Specific Autoantigens. Autoimmunity 36:6-7, pages 361-366.
Read now

Articles from other publishers (49)

Praveen Prashant, Renu Garg, Piyush Bansal & Sonia Praveen. (2023) Thyroid Autoimmunity in Vitiligo: A Case-Control Study. Cureus.
Crossref
Yaosheng Luo, Huixian Zeng, Yanshi Ye, Genfeng Yu, Cheng Song, Siyang Liu, Xingying Chen, Yuqi Jiang, Hualin Duan, Yue Li, Shengqing He, Zhi Chen, Lingling Liu, Yongqian Liang, Xu Lin, Heng Wan & Jie Shen. (2022) Associations of metal profiles in blood with thyroiditis: a cross-sectional study. Environmental Science and Pollution Research 30:8, pages 21072-21080.
Crossref
Xiao‐Mei Sun, Shi‐Min Zhuang, Zhi‐Wen Xiao, Jia‐Qi Luo, Zhen Long, Lin‐Chan Lan, Hui‐Qing Zhang & Guan‐Ping Zhang. (2022) Autoimmune thyroiditis in patients with sudden sensorineural hearing loss. Laryngoscope Investigative Otolaryngology 7:2, pages 571-577.
Crossref
Meenakshi Sundaram Andra Suryanarayana, Kishore Vellingiri, Saransh Kumar Agarwal N & Bhushan Mohan. (2021) Can Early Thyroid Profiling Help Avert Spontaneous Abortions/Early Pregnancy Loss: A Retrospective Study. Cureus.
Crossref
Hanan S. Ahmed, Ayman A.M. Nsrallah, Azza H. Abdel-Fatah, Amira A. Mahmoud & Abeer A. Fikry. (2021) Association of Thyroid Peroxidase Gene Polymorphisms and Serum Anti- TPO Levels in Egyptian Patients with Autoimmune Hypothyroidism. Endocrine, Metabolic & Immune Disorders - Drug Targets 21:4, pages 734-742.
Crossref
Oliver Schmetzer, Elisa Lakin, Ben Roediger, Ankelien Duchow, Susanna Asseyer, Friedemann Paul & Nadja Siebert. (2021) Anti-aquaporin 4 IgG Is Not Associated With Any Clinical Disease Characteristics in Neuromyelitis Optica Spectrum Disorder. Frontiers in Neurology 12.
Crossref
Luka Brčić, Ana Barić, Sanda Gračan, Vesela Torlak, Marko Brekalo, Veselin Škrabić, Tatijana Zemunik, Maja Barbalić, Ante Punda & Vesna Boraska Perica. (2019) Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto’s thyroiditis. Scientific Reports 9:1.
Crossref
Anatoly V. Skalny, Lydmila L. Klimenko, Aliya A. Turna, Maria N. Budanova, Ivan S. Baskakov, Marina S. Savostina, Aksana N. Mazilina, Anatoly I. Deyev, Margarita G. Skalnaya & Alexey A. Tinkov. (2017) Serum trace elements are interrelated with hormonal imbalance in men with acute ischemic stroke. Journal of Trace Elements in Medicine and Biology 43, pages 142-147.
Crossref
Atanaska Elenkova, Iliana Аtanasova, Georgi Кirilov, Еmil Natchev, Ralitza Ivanova, Roussanka Кovatcheva, Silvia Vandeva, Dimitar Tcharaktchiev & Sabina Zacharieva. (2017) Autoimmune hypothyroidism is three times more frequent in female prolactinoma patients compared to healthy women: data from a cross-sectional case-control study. Endocrine 57:3, pages 486-493.
Crossref
Saki Tomari, Mikio Watanabe, Naoya Inoue, Tomoyo Mizuma, Chika Yamanaka, Yoh Hidaka & Yoshinori Iwatani. (2017) The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of anti-thyroid peroxidase antibody. Endocrine Journal 64:10, pages 1025-1032.
Crossref
Manish Kumar Gupta & Krishna Misra. (2013) Modeling and simulation analysis of propyl-thiouracil (PTU), an anti-thyroid drug on thyroid peroxidase (TPO), thyroid stimulating hormone receptor (TSHR), and sodium iodide (NIS) symporter based on systems biology approach. Network Modeling Analysis in Health Informatics and Bioinformatics 2:1, pages 45-57.
Crossref
Leonidas Duntas, Stefanos Geroulanos & Peter Laurberg. (2013) From Hippocrates of Kos to Hashimoto and thyroid autoimmunity: A long road of discovery. Hormones 12:1, pages 9-11.
Crossref
Ross Comerford, Greg Byrne, Conleth Feighery & Jacinta Kelly. (2012) Binding of Autoantibodies to the Core Region of Tissue Transglutaminase Is a Feature of Paediatric Coeliac Disease. Journal of Pediatric Gastroenterology & Nutrition 55:4, pages 445-450.
Crossref
S A Rebuffat, M Morin, B Nguyen, F Castex, B Robert & S Péraldi-Roux. (2010) Human recombinant anti-thyroperoxidase autoantibodies: in vitro cytotoxic activity on papillary thyroid cancer expressing TPO. British Journal of Cancer 102:5, pages 852-861.
Crossref
H. Hadj-Kacem, S. Rebuffat, M. Mnif-Féki, S. Belguith-Maalej, H. Ayadi & S. Péraldi-Roux. (2009) Autoimmune thyroid diseases: genetic susceptibility of thyroid-specific genes and thyroid autoantigens contributions. International Journal of Immunogenetics 36:2, pages 85-96.
Crossref
Jeffrey S Rumbyrt & Alan L Schocket. 2008. Thyroid Disorders with Cutaneous Manifestations. Thyroid Disorders with Cutaneous Manifestations 145 156 .
Francesco Latrofa & Aldo Pinchera. 2008. Autoimmune Diseases in Endocrinology. Autoimmune Diseases in Endocrinology 137 176 .
Sandra M. McLachlanBasil Rapoport. (2007) Thyroid Peroxidase as an Autoantigen. Thyroid 17:10, pages 939-948.
Crossref
Sandra A. Rebuffat, Damien Bresson, Brigitte Nguyen & Sylvie Péraldi-Roux. (2006) The key residues in the immunodominant region 353–363 of human thyroid peroxidase were identified. International Immunology 18:7, pages 1091-1099.
Crossref
H. P. Ng & Annie W. C. Kung. (2006) Induction of Autoimmune Thyroiditis and Hypothyroidism by Immunization of Immunoactive T Cell Epitope of Thyroid Peroxidase. Endocrinology 147:6, pages 3085-3092.
Crossref
Eystein S. Husebye, Eirik Bratland, Geir Bredholt, Mati Fridkin, Molly Dayan & Edna Mozes. (2006) The Substrate-Binding Domain of 21-Hydroxylase, the Main Autoantigen in Autoimmune Addison’s Disease, Is an Immunodominant T Cell Epitope. Endocrinology 147:5, pages 2411-2416.
Crossref
Pia S Hansen, Thomas H Brix, Ivan Iachine, Kirsten O Kyvik & Laszlo Hegedüs. (2006) The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins. European Journal of Endocrinology 154:1, pages 29-38.
Crossref
Renato Tozzoli, Danilo Villalta, Graziano Kodermaz, Marcello Bagnasco, Elio Tonutti & Nicola Bizzaro. (2006) Autoantibody profiling of patients with autoimmune thyroid disease using a new multiplexed immunoassay method. Clinical Chemistry and Laboratory Medicine (CCLM) 44:7.
Crossref
Damien Bresson, Sandra A Rebuffat & Sylvie Péraldi-Roux. (2005) Localization of the immunodominant region on human thyroid peroxidase in autoimmune thyroid diseases: an update. Journal of Autoimmune Diseases 2:1.
Crossref
Felix Mor, Marina Izak & Irun R. Cohen. (2005) Identification of Aldolase as a Target Antigen in Alzheimer’s Disease. The Journal of Immunology 175:5, pages 3439-3445.
Crossref
Carlos A. Garcia, Kamalaveni R. Prabakar, Juan Diez, Zhu Alexander Cao, Gloria Allende, Markus Zeller, Rajpreet Dogra, Armando Mendez, Eliot Rosenkranz, Ulf Dahl, Camillo Ricordi, Douglas Hanahan & Alberto Pugliese. (2005) Dendritic Cells in Human Thymus and Periphery Display a Proinsulin Epitope in a Transcription-Dependent, Capture-Independent Fashion. The Journal of Immunology 175:4, pages 2111-2122.
Crossref
Damien Bresson, Sandra A. Rebuffat, Brigitte Nguyen, J. Paul Banga, Andrzej Gardas & Sylvie Peraldi-Roux. (2005) New Insights into the Conformational Dominant Epitopes on Thyroid Peroxidase Recognized by Human Autoantibodies. Endocrinology 146:6, pages 2834-2844.
Crossref
Mark F. Prummel & Wilmar M. Wiersinga. (2005) Thyroid peroxidase autoantibodies in euthyroid subjects. Best Practice & Research Clinical Endocrinology & Metabolism 19:1, pages 1-15.
Crossref
Marjan C. Slot, Thera P. Links, Coen A. Stegeman & Jan Willem Cohen Tervaert. (2005) Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long-term followup study. Arthritis & Rheumatism 53:1, pages 108-113.
Crossref
Damien Bresson, Martine Pugnière, Françoise Roquet, Sandra A. Rebuffat, Brigitte N-Guyen, Martine Cerutti, Jin Guo, Sandra M. McLachlan, Basil Rapoport, Valérie Estienne, Jean Ruf, Thierry Chardès & Sylvie Péraldi-Roux. (2004) Directed Mutagenesis in Region 713-720 of Human Thyroperoxidase Assigns 713KFPED717 Residues as Being Involved in the B Domain of the Discontinuous Immunodominant Region Recognized by Human Autoantibodies. Journal of Biological Chemistry 279:37, pages 39058-39067.
Crossref
Vincent GeenenGherardo Mazziotti & Marian Elizabeth Ludgate. 2004. Immunoendocrinology in Health and Disease. Immunoendocrinology in Health and Disease 461 490 .
Sandra M. McLachlan & Basil Rapoport. (2004) Why Measure Thyroglobulin Autoantibodies Rather Than Thyroid Peroxidase Autoantibodies?. Thyroid 14:7, pages 510-520.
Crossref
Carmen Segundo, Carmen Rodríguez, Manuel Aguilar, Antonio García-Poley, Inmaculada Gavilán, Carmen Bellas & José A. Brieva. (2004) Differences in Thyroid-Infiltrating B Lymphocytes in Patients with Graves' Disease: Relationship to Autoantibody Detection. Thyroid 14:5, pages 337-344.
Crossref
Mário Vaisman, Doris Rosenthal & Denise P. Carvalho. (2004) Enzimas envolvidas na organificação tireoideana do iodo. Arquivos Brasileiros de Endocrinologia & Metabologia 48:1, pages 9-15.
Crossref
Yuji Nagayama. (2003) Novel murine models of thyroid autoimmunity. Current Opinion in Endocrinology & Diabetes 10:5, pages 364-370.
Crossref
J GUO, P PICHURIN, Y NAGAYAMA, B RAPOPORT & S M MCLACHLAN. (2003) Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. Clinical and Experimental Immunology 132:3, pages 408-415.
Crossref
Damien Bresson, Martine Cerutti, Gérard Devauchelle, Martine Pugnière, Françoise Roquet, Cédric Bès, Carine Bossard, Thierry Chardès & Sylvie Péraldi-Roux. (2003) Localization of the Discontinuous Immunodominant Region Recognized by Human Anti-thyroperoxidase Autoantibodies in Autoimmune Thyroid Diseases. Journal of Biological Chemistry 278:11, pages 9560-9569.
Crossref
Wim Janssens, Marinee K.L. Chuah, Luigi Naldini, Antonia Follenzi, Désiré Collen, Jean-Marie Saint-Remy & Thierry VandenDriessche. (2003) Efficiency of Onco-Retroviral and Lentiviral Gene Transfer into Primary Mouse and Human B-Lymphocytes Is Pseudotype Dependent. Human Gene Therapy 14:3, pages 263-276.
Crossref
Francesco Latrofa, Pavel Pichurin, Jin Guo, Basil Rapoport & Sandra M. McLachlan. (2003) Thyroglobulin-Thyroperoxidase Autoantibodies Are Polyreactive, Not Bispecific: Analysis Using Human Monoclonal Autoantibodies. The Journal of Clinical Endocrinology & Metabolism 88:1, pages 371-378.
Crossref
Pavel N. Pichurin, Jin Guo, Valerie Estienne, Pierre Carayon, Jean Ruf, Basil Rapoport & Sandra M. McLachlan. (2002) Evidence that the Complement Control Protein-Epidermal Growth Factor-Like Domain of Thyroid Peroxidase Lies on the Fringe of the Immunodominant Region Recognized by Autoantibodies. Thyroid 12:12, pages 1085-1095.
Crossref
Jin Guo, Sandra M. McLachlan & Basil Rapoport. (2002) Localization of the Thyroid Peroxidase Autoantibody Immunodominant Region to a Junctional Region Containing Portions of the Domains Homologous to Complement Control Protein and Myeloperoxidase. Journal of Biological Chemistry 277:43, pages 40189-40195.
Crossref
Mikio Watanabe, Naoko Yamamoto, Hayato Maruoka, Hajime Tamai, Fumio Matsuzuka, Akira Miyauchi & Yoshinori Iwatani. (2002) Independent Involvement of CD8 + CD25 + Cells and Thyroid Autoantibodies in Disease Severity of Hashimoto's Disease . Thyroid 12:9, pages 801-808.
Crossref
Stéphanie Blanchin, Valérie Estienne, Jin Guo, Basil Rapoport, Sandra M McLachlan, Pierre Carayon & Jean Ruf. (2002) Human thyroperoxidase folds in one complex B-cell immunodominant region. Biochemical and Biophysical Research Communications 295:5, pages 1118-1124.
Crossref
Valérie Estienne, Christine Duthoit, Stéphanie Blanchin, Roland Montserret, Josée‐Martine Durand‐Gorde, Martine Chartier, Daniel Baty, Pierre Carayon & Jean Ruf. (2002) Analysis of a conformational B cell epitope of human thyroid peroxidase: identification of a tyrosine residue at a strategic location for immunodominance. International Immunology 14:4, pages 359-366.
Crossref
Basil Rapoport & Sandra M. McLachlan. (2001) Thyroid autoimmunity. Journal of Clinical Investigation 108:9, pages 1253-1259.
Crossref
Basil Rapoport & Sandra M. McLachlan. (2001) Thyroid autoimmunity. Journal of Clinical Investigation 108:9, pages 1253-1259.
Crossref
Maria Pilar Armengol, Manel Juan, Anna Lucas-Martín, María Teresa Fernández-Figueras, Dolores Jaraquemada, Teresa Gallart & Ricardo Pujol-Borrell. (2001) Thyroid Autoimmune Disease. The American Journal of Pathology 159:3, pages 861-873.
Crossref
Pavel Pichurin, Jin Guo, Xinmin Yan, Basil Rapoport & Sandra M. McLachlan. (2001) Human Monoclonal Autoantibodies to B-Cell Epitopes Outside the Thyroid Peroxidase Autoantibody Immunodominant Region. Thyroid 11:4, pages 301-313.
Crossref
Jin Guo, Xin-Min Yan, Sandra M. McLachlan & Basil Rapoport. (2001) Search for the Autoantibody Immunodominant Region on Thyroid Peroxidase: Epitopic Footprinting with a Human Monoclonal Autoantibody Locates a Facet on the Native Antigen Containing a Highly Conformational Epitope. The Journal of Immunology 166:2, pages 1327-1333.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.