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Review Articles

Homing Pathways of Mesenchymal Stromal Cells (MSCs) and Their Role in Clinical Applications

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Pages 514-529 | Published online: 14 Sep 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Junlin Chen, Jingwei Jiang, Wei Wang, Juan Qin, Jinyun Chen, Wenzhi Chen & Yan Wang. (2019) Low intensity pulsed ultrasound promotes the migration of bone marrow- derived mesenchymal stem cells via activating FAK-ERK1/2 signalling pathway. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 3603-3613.
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Fei-Ting Hsu, Zung-Hang Wei, Yogi Chang-Yo Hsuan, Willie Lin, Yu-Chin Su, Chia-Hui Liao & Chia-Ling Hsieh. (2018) MRI tracking of polyethylene glycol-coated superparamagnetic iron oxide-labelled placenta-derived mesenchymal stem cells toward glioblastoma stem-like cells in a mouse model. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 448-459.
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Articles from other publishers (47)

Joana R. Dantas, Debora Batista Araujo, Karina Ribeiro Silva, Debora Lopes Souto, Maria de Fatima Carvalho Pereira, Luiz Ronir Raggio, Cesar Claudio-da Silva, Carlos Eduardo Couri, Angelo Maiolino, Carmen Lucia Kuniyoshi Rebellato, Debora Regina Daga, Alexandra Cristina Senegaglia, Paulo Roberto Slud Brofman, Leandra S. Baptista, Jose Egidio Paulo de Oliveira, Lenita Zajdenverg & Melanie Rodacki. (2023) Adipose Tissue-Derived Stromal/Stem Cells Transplantation with Cholecalciferol Supplementation in Recent-Onset Type 1 Diabetes Patients: Twelve Months Follow-Up. Hormone and Metabolic Research 55:08, pages 536-545.
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Junhou Lu, Yu Zhang, Dongyan Wang, Xiaojing Xu, Jianwei Xu, Xinyu Yang, Hongxiang Qian & Huanxiang Zhang. (2023) Basic Fibroblast Growth Factor Promotes Mesenchymal Stem Cell Migration by Regulating Glycolysis-Dependent β-Catenin Signaling. Stem Cells 41:6, pages 628-642.
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Jing Wang, Jun Tian, Lin Wang, Zhi‐wen Yang & Ping Xu. (2022) Mesenchymal stem cells regulate M1 polarization of peritoneal macrophages through the CARD9‐NF‐κB signaling pathway in severe acute pancreatitis. Journal of Hepato-Biliary-Pancreatic Sciences 30:3, pages 338-350.
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QingHua Yin, TianHao Zou, ShuJun Sun & Dong Yang. (2023) Cell therapy for neuropathic pain. Frontiers in Molecular Neuroscience 16.
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Lan Shi, Zhifen Zhang, Miao Deng, Fangyuan Zheng, Wenhua Liu & Shujin Ye. (2022) Biological mechanisms and applied prospects of mesenchymal stem cells in premature ovarian failure. Medicine 101:32, pages e30013.
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Dana Nir, Ivana Ribarski-Chorev, Chen Shimoni, Carmit Strauss, Jan Frank & Sharon Schlesinger. (2022) Antioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cells. International Journal of Molecular Sciences 23:10, pages 5750.
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KENJI TSUJI, SHINJI KITAMURA & JUN WADA. (2022) Mesenchymal stem cells-derived extracellular vesicles as ‘natural’ drug delivery system for tissue regeneration. BIOCELL 46:4, pages 899-902.
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Eun-Young Kim, Hyuk Soon Kim, Ki-Sung Hong, Hyung-Min Chung, Se-Pill Park & Geunwoong Noh. (2021) Mesenchymal stem/stromal cell therapy in atopic dermatitis and chronic urticaria: immunological and clinical viewpoints. Stem Cell Research & Therapy 12:1.
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Noriyasu Kamei, Haruka Nishimura, Atsushi Matsumoto, Riho Asano, Kanae Muranaka, Mahiro Fujita, Miina Takeda, Hiro Hashimoto & Mariko Takeda-Morishita. (2021) Comparative study of commercial protocols for high recovery of high-purity mesenchymal stem cell-derived extracellular vesicle isolation and their efficient labeling with fluorescent dyes. Nanomedicine: Nanotechnology, Biology and Medicine 35, pages 102396.
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Chun-Te Ho, Mei-Hsuan Wu, Ming-Jen Chen, Shih-Pei Lin, Yu-Ting Yen & Shih-Chieh Hung. (2021) Combination of Mesenchymal Stem Cell-Delivered Oncolytic Virus with Prodrug Activation Increases Efficacy and Safety of Colorectal Cancer Therapy. Biomedicines 9:5, pages 548.
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Linyu Yang, Haoping Dai, Jian Yang, Han Yang, Daoyin Yang & Jianping Kang. (2021) Molecular Mechanism of Neurotrophic Factor-Activated Long Non-Coding RNA Plasmacytoma Variant Translocation 1 Promoting Mesenchymal Stem Cell Migration and Repair of Fractures. Journal of Biomaterials and Tissue Engineering 11:5, pages 943-947.
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Yuanqin Su, Tianyuan Zhang, Ting Huang & Jianqing Gao. (2021) Current advances and challenges of mesenchymal stem cells-based drug delivery system and their improvements. International Journal of Pharmaceutics 600, pages 120477.
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Mohamed M. Kamal & Dina H. Kassem. (2020) Therapeutic Potential of Wharton’s Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges. Frontiers in Cell and Developmental Biology 8.
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Fahad Munir, Muhammad B. Jamshed, Numan Shahid, Syed A. Muhammad, Noor B. Ghanem & Zhang Qiyu. (2019) Current status of diagnosis and Mesenchymal stem cells therapy for acute pancreatitis. Physiological Reports 7:21.
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Jennifer L. Spiegel, Mario Hambrecht, Vera Kohlbauer, Frank Haubner, Friedrich Ihler, Martin Canis, Arndt F. Schilling, Kai O. Böker, Ralf Dressel, Katrin Streckfuss‐Bömeke & Mark Jakob. (2019) Radiation‐induced sensitivity of tissue‐resident mesenchymal stem cells in the head and neck region. Head & Neck 41:9, pages 2892-2903.
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Shuaishuai HuangYu RenXue WangLissy LazarSuya MaGuobin WengJinshun Zhao. (2019) Application of Ultrasound-Targeted Microbubble Destruction–Mediated Exogenous Gene Transfer in Treating Various Renal Diseases. Human Gene Therapy 30:2, pages 127-138.
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Yiru Shao, Fangqing Zhou, Daikun He, Lin Zhang & Jie Shen. (2019) Overexpression of CXCR7 promotes mesenchymal stem cells to repair phosgene-induced acute lung injury in rats. Biomedicine & Pharmacotherapy 109, pages 1233-1239.
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Anshu Sharma & Rajni Rani. (2017) Do we really need to differentiate mesenchymal stem cells into insulin-producing cells for attenuation of the autoimmune responses in type 1 diabetes: immunoprophylactic effects of precursors to insulin-producing cells. Stem Cell Research & Therapy 8:1.
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Franziska Nitzsche, Claudia Müller, Barbara Lukomska, Jukka Jolkkonen, Alexander Deten & Johannes Boltze. (2017) Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration. STEM CELLS 35:6, pages 1446-1460.
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Nabil A. Soliman, Somia H. Abd-Allah, Samia Hussein & Muhammad Alaa Eldeen. (2017) Factors enhancing the migration and the homing of mesenchymal stem cells in experimentally induced cardiotoxicity in rats. IUBMB Life 69:3, pages 162-169.
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Tae-Hoon Shin, Hyung-Sik Kim, Soon Choi & Kyung-Sun Kang. (2017) Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action. International Journal of Molecular Sciences 18:2, pages 244.
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Gong Wang, Qian Zhang, Zhongxiong Zhuo, Shengzheng Wu, Zheng Liu, Hongmei Xia, Kaibin Tan, Linru Zou, Ling Gan & Yunhua Gao. (2015) Effects of diagnostic ultrasound-targeted microbubble destruction on the homing ability of bone marrow stromal cells to the kidney parenchyma. European Radiology 26:9, pages 3006-3016.
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Mohamed Y. Salem, Nahla El-Eraky El-Azab & Rania Ibrahem. (2016) Effect of the route of stem cell transplantation on its therapeutic potential on induced myopathy in rats. The Egyptian Journal of Histology 39:1, pages 74-86.
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Gong Wang, Qian Zhang, Zhongxiong Zhuo, Shengzheng Wu, Yali Xu, Linru Zou, Ling Gan, Kaibin Tan, Hongmei Xia, Zheng Liu & Yunhua Gao. (2016) Enhanced Homing of CXCR-4 Modified Bone Marrow–Derived Mesenchymal Stem Cells to Acute Kidney Injury Tissues by Micro-Bubble–Mediated Ultrasound Exposure. Ultrasound in Medicine & Biology 42:2, pages 539-548.
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F Gao, S M Chiu, D A L Motan, Z Zhang, L Chen, H-L Ji, H-F Tse, Q-L Fu & Q Lian. (2016) Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death & Disease 7:1, pages e2062-e2062.
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Yunting Zhou, Qi Hu, Fuyi Chen, Juan Zhang, Jincheng Guo, Hongwu Wang, Jiang Gu, Lian Ma & Guyu Ho. (2015) Human umbilical cord matrix-derived stem cells exert trophic effects on β-cell survival in diabetic rats and isolated islets. Disease Models & Mechanisms 8:12, pages 1625-1633.
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Gong Wang, Zhongxiong Zhuo, Bin Yang, Shengzheng Wu, Yali Xu, Zheng Liu, Kaibin Tan, Hongmei Xia, Xiaoyan Wang, Linru Zou, Ling Gan & Yunhua Gao. (2015) Enhanced Homing Ability and Retention of Bone Marrow Stromal Cells to Diabetic Nephropathy by Microbubble-Mediated Diagnostic Ultrasound Irradiation. Ultrasound in Medicine & Biology 41:11, pages 2977-2989.
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Silvia Cerri, Rosaria Greco, Giovanna Levandis, Cristina Ghezzi, Antonina Stefania Mangione, Marie-Therese Fuzzati-Armentero, Arianna Bonizzi, Maria Antonietta Avanzini, Rita Maccario & Fabio Blandini. (2015) Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson's Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects. Stem Cells Translational Medicine 4:9, pages 1073-1085.
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Krisztian Nemeth & Eva Mezey. (2015) Bone marrow stromal cells as immunomodulators. A primer for dermatologists. Journal of Dermatological Science 77:1, pages 11-20.
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Xiaoting Liang, Yue Ding, Yuelin Zhang, Hung-Fat Tse & Qizhou Lian. (2014) Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives. Cell Transplantation 23:9, pages 1045-1059.
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Robert Wyse, Gary Dunbar & Julien Rossignol. (2014) Use of Genetically Modified Mesenchymal Stem Cells to Treat Neurodegenerative Diseases. International Journal of Molecular Sciences 15:2, pages 1719-1745.
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Debanjana Chatterjee, Dejene Milkessa Tufa, Heike Baehre, Ralf Hass, Reinhold Ernst Schmidt & Roland Jacobs. (2014) Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells. Blood 123:4, pages 594-595.
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Marisa Karow. (2013) Mountaineering pericytes - A universal key to tissue repair?. BioEssays 35:9, pages 771-774.
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Yulyana YulyanaBerwini B. EndayaWai H. NgChang M. GuoKam M. HuiPaula Y.P. LamIvy A.W. Ho. (2013) Carbenoxolone Enhances TRAIL -Induced Apoptosis Through the Upregulation of Death Receptor 5 and Inhibition of Gap Junction Intercellular Communication in Human Glioma . Stem Cells and Development 22:13, pages 1870-1882.
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Y-F Huang, M-J Chen, M-H Wu & S-C Hung. (2013) The use of hypoxic cultured mesenchymal stem cell for oncolytic virus therapy. Cancer Gene Therapy 20:5, pages 308-316.
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Javier G. Casado, R. Tarazona & F. M. Sanchez-Margallo. (2013) NK and MSCs Crosstalk: The Sense of Immunomodulation and Their Sensitivity. Stem Cell Reviews and Reports 9:2, pages 184-189.
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Lena DreherSusanne Elvers-HornungIrena BrinkmannVolker HuckReinhard HenschlerTorsten GloeHarald KlüterKaren Bieback. (2013) Cultivation in Human Serum Reduces Adipose Tissue-Derived Mesenchymal Stromal Cell Adhesion to Laminin and Endothelium and Reduces Capillary Entrapment. Stem Cells and Development 22:5, pages 791-803.
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Irina V Kholodenko, Alina A Konieva, Roman V Kholodenko & Konstantin N Yarygin. (2013) Molecular mechanisms of migration and homing of intravenously transplanted mesenchymal stem cells. journal of Regenerative Medicine and Tissue Engineering 2:1, pages 2.
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I Vegh, M Grau, M Gracia, J Grande, P de la Torre & A I Flores. (2012) Decidua mesenchymal stem cells migrated toward mammary tumors in vitro and in vivo affecting tumor growth and tumor development. Cancer Gene Therapy 20:1, pages 8-16.
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Bing Huang, Yasuhiko Tabata & Jian-Qing Gao. (2012) Mesenchymal stem cells as therapeutic agents and potential targeted gene delivery vehicle for brain diseases. Journal of Controlled Release 162:2, pages 464-473.
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Katrina McNulty & Sam M. Janes. (2012) Stem Cells and Pulmonary Fibrosis: Cause or Cure?. Proceedings of the American Thoracic Society 9:3, pages 164-171.
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Ali Ziadloo, Scott R. Burks, Eric M. Gold, Bobbi K. Lewis, Aneeka Chaudhry, Maria J. Merino, Victor Frenkel & Joseph A. Frank. (2012) Enhanced Homing Permeability and Retention of Bone Marrow Stromal Cells by Noninvasive Pulsed Focused Ultrasound. Stem Cells 30:6, pages 1216-1227.
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Sung Keun Kang, Il Seob Shin, Myung Soon Ko, Jung Youn Jo & Jeong Chan Ra. (2012) Journey of Mesenchymal Stem Cells for Homing: Strategies to Enhance Efficacy and Safety of Stem Cell Therapy. Stem Cells International 2012, pages 1-11.
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Nitin Wadhawan, Harmandeep Kalkat, Kanmani Natarajan, Xiuli Ma, Sivakumar Gajjeraman, Saravanan Nandagopal, Ning Hao, Jing Li, Michael Zhang, Jixian Deng, Bo Xiang, Shadreck Mzengeza, Darren H. Freed, Rakesh C. Arora, Ganghong Tian & Francis Lin. (2012) Growth and positioning of adipose-derived stem cells in microfluidic devices. Lab on a Chip 12:22, pages 4829.
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Daniel L. Coutu, Moïra François & Jacques Galipeau. 2012. Regenerative Therapy Using Blood-Derived Stem Cells. Regenerative Therapy Using Blood-Derived Stem Cells 35 51 .
Jeong Chan Ra, Sung Keun Kang, Il Seob Shin, Hyeong Geun Park, Sang Aun Joo, Jeong Geun Kim, Byeong-Cheol Kang, Yong Soon Lee, Ken Nakama, Min Piao, Bertram Sohl & Andras Kurtz. (2011) Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells. Journal of Translational Medicine 9:1.
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Scott R. Burks, Ali Ziadloo, Hilary A. Hancock, Aneeka Chaudhry, Dana D. Dean, Bobbi K. Lewis, Victor Frenkel & Joseph A. Frank. (2011) Investigation of Cellular and Molecular Responses to Pulsed Focused Ultrasound in a Mouse Model. PLoS ONE 6:9, pages e24730.
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