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Review Articles

Influenza Virus RNA Structure: Unique and Common Features

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Pages 533-556 | Published online: 05 Oct 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

M. I. Spronken, C. E. van de Sandt, E. P. de Jongh, O. Vuong, S. van der Vliet, T. M. Bestebroer, R. C. L. Olsthoorn, G. F. Rimmelzwaan, R.A. M. Fouchier & A. P. Gultyaev. (2017) A compensatory mutagenesis study of a conserved hairpin in the M gene segment of influenza A virus shows its role in virus replication. RNA Biology 14:11, pages 1606-1616.
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Alexander P Gultyaev, Anton Tsyganov-Bodounov, Monique IJ Spronken, Sander van der Kooij, Ron AM Fouchier & René CL Olsthoorn. (2014) RNA structural constraints in the evolution of the influenza A virus genome NP segment. RNA Biology 11:7, pages 942-952.
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Andrey Chursov, Sebastian J. Kopetzky, Ignaty Leshchiner, Ivan Kondofersky, Fabian J. Theis, Dmitrij Frishman & Alexander Shneider. (2012) Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus. RNA Biology 9:10, pages 1266-1274.
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Articles from other publishers (35)

Ivar W. Dilweg, Jasper Peer & René C. L. Olsthoorn. (2023) Xrn1-resistant RNA motifs are disseminated throughout the RNA virome and are able to block scanning ribosomes. Scientific Reports 13:1.
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Maria Nalewaj & Marta Szabat. (2022) Examples of Structural Motifs in Viral Genomes and Approaches for RNA Structure Characterization. International Journal of Molecular Sciences 23:24, pages 15917.
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Amit Kumar & Harish Vashisth. (2022) Role of Mutations in Differential Recognition of Viral RNA Molecules by Peptides. Journal of Chemical Information and Modeling 62:14, pages 3381-3390.
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Joseph T. Hicks, Kimberly Edwards, Xueting Qiu, Do-Kyun Kim, James E. Hixson, Scott Krauss, Richard J. Webby, Robert G. Webster & Justin Bahl. (2022) Host diversity and behavior determine patterns of interspecies transmission and geographic diffusion of avian influenza A subtypes among North American wild reservoir species. PLOS Pathogens 18:4, pages e1009973.
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Barbara Szutkowska, Klaudia Wieczorek, Ryszard Kierzek, Pawel Zmora, Jake M. Peterson, Walter N. Moss, David H. Mathews & Elzbieta Kierzek. (2022) Secondary Structure of Influenza A Virus Genomic Segment 8 RNA Folded in a Cellular Environment. International Journal of Molecular Sciences 23:5, pages 2452.
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Jake M. Peterson, Collin A. O’Leary & Walter N. Moss. (2022) In silico analysis of local RNA secondary structure in influenza virus A, B and C finds evidence of widespread ordered stability but little evidence of significant covariation. Scientific Reports 12:1.
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Xiuli Li, Min Gu, Qinmei Zheng, Ruyi Gao & Xiufan Liu. (2021) Packaging signal of influenza A virus. Virology Journal 18:1.
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Marta Soszynska-Jozwiak, Maciej Pszczola, Julita Piasecka, Jake M. Peterson, Walter N. Moss, Katarzyna Taras-Goslinska, Ryszard Kierzek & Elzbieta Kierzek. (2021) Universal and strain specific structure features of segment 8 genomic RNA of influenza A virus—application of 4-thiouridine photocrosslinking. Journal of Biological Chemistry 297:6, pages 101245.
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Maria Tomaszewska, Marta Szabat, Karolina Zielińska & Ryszard Kierzek. (2021) Identification and Structural Aspects of G-Quadruplex-Forming Sequences from the Influenza A Virus Genome. International Journal of Molecular Sciences 22:11, pages 6031.
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Paula Michalak, Julita Piasecka, Barbara Szutkowska, Ryszard Kierzek, Ewa Biala, Walter N. Moss & Elzbieta Kierzek. (2021) Conserved Structural Motifs of Two Distant IAV Subtypes in Genomic Segment 5 RNA. Viruses 13:3, pages 525.
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Irina L. Baranovskaya, Mariia V. Sergeeva, Aleksandr S. Taraskin, Alexey A. Lozhkov & Andrey V. Vasin. (2021) Mutations designed to modify the NS gene mRNA secondary structure affect influenza A pathogenicity in vivo. Microbiology Independent Research Journal (MIR Journal) 8:1.
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Julita Piasecka, Aleksandra Jarmolowicz & Elzbieta Kierzek. (2020) Organization of the Influenza A Virus Genomic RNA in the Viral Replication Cycle—Structure, Interactions, and Implications for the Emergence of New Strains. Pathogens 9:11, pages 951.
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Julita Piasecka, Elzbieta Lenartowicz, Marta Soszynska-Jozwiak, Barbara Szutkowska, Ryszard Kierzek & Elzbieta Kierzek. (2020) RNA Secondary Structure Motifs of the Influenza A Virus as Targets for siRNA-Mediated RNA Interference. Molecular Therapy - Nucleic Acids 19, pages 627-642.
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Manchugondanahalli S. Krishna, Zhenzhang Wang, Liangzhen Zheng, Jogesh BowryAlan Ann Lerk Ong, Yuguang Mu, Mookkan Prabakaran & Gang Chen. (2019) Incorporating G-C Pair-Recognizing Guanidinium into PNAs for Sequence and Structure Specific Recognition of dsRNAs over dsDNAs and ssRNAs. Biochemistry 58:36, pages 3777-3788.
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Manchugondanahalli S. Krishna, Desiree-Faye Kaixin Toh, Zhenyu Meng, Alan Ann Lerk Ong, Zhenzhang Wang, Yunpeng Lu, Kelin Xia, Mookkan Prabakaran & Gang Chen. (2019) Sequence- And Structure-Specific Probing of RNAs by Short Nucleobase-Modified dsRNA-Binding PNAs Incorporating a Fluorescent Light-up Uracil Analog. Analytical Chemistry 91:8, pages 5331-5338.
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Julita Kesy, Kiran M. Patil, Subaschandrabose Rajesh Kumar, Zhiyu Shu, Hui Yee Yong, Louis Zimmermann, Alan Ann Lerk Ong, Desiree-Faye Kaixin Toh, Manchugondanahalli S. Krishna, Lixia Yang, Jean-Luc Decout, Dahai Luo, Mookkan Prabakaran, Gang Chen & Elzbieta Kierzek. (2019) A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure. Bioconjugate Chemistry 30:3, pages 931-943.
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Paula Michalak, Marta Soszynska-Jozwiak, Ewa Biala, Walter N. Moss, Julita Kesy, Barbara Szutkowska, Elzbieta Lenartowicz, Ryszard Kierzek & Elzbieta Kierzek. (2019) Secondary structure of the segment 5 genomic RNA of influenza A virus and its application for designing antisense oligonucleotides. Scientific Reports 9:1.
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Damien Ferhadian, Maud Contrant, Anne Printz-Schweigert, Redmond P. Smyth, Jean-Christophe Paillart & Roland Marquet. (2018) Structural and Functional Motifs in Influenza Virus RNAs. Frontiers in Microbiology 9.
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Marta Soszynska-Jozwiak, Paula Michalak, Walter N. Moss, Ryszard Kierzek, Julita Kesy & Elzbieta Kierzek. (2017) Influenza virus segment 5 (+)RNA - secondary structure and new targets for antiviral strategies. Scientific Reports 7:1.
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Ashley Sobel Leonard, Micah T. McClain, Gavin J. D. Smith, David E. Wentworth, Rebecca A. Halpin, Xudong Lin, Amy Ransier, Timothy B. Stockwell, Suman R. Das, Anthony S. Gilbert, Rob Lambkin-Williams, Geoffrey S. Ginsburg, Christopher W. Woods, Katia Koelle & Christopher J. R. Illingworth. (2017) The effective rate of influenza reassortment is limited during human infection. PLOS Pathogens 13:2, pages e1006203.
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Alexander P. Gultyaev, Monique I. Spronken, Mathilde Richard, Eefje J. A. Schrauwen, René C. L. Olsthoorn & Ron A. M. Fouchier. (2016) Subtype-specific structural constraints in the evolution of influenza A virus hemagglutinin genes. Scientific Reports 6:1.
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Agnieszka Ruszkowska, Elzbieta Lenartowicz, Walter N. Moss, Ryszard Kierzek & Elzbieta Kierzek. (2016) Secondary structure model of the naked segment 7 influenza A virus genomic RNA. Biochemical Journal 473:23, pages 4327-4348.
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Catherine Isel, Sandie Munier & Nadia Naffakh. (2016) Experimental Approaches to Study Genome Packaging of Influenza A Viruses. Viruses 8:8, pages 218.
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Sarah M. McDonald, Martha I. Nelson, Paul E. Turner & John T. Patton. (2016) Reassortment in segmented RNA viruses: mechanisms and outcomes. Nature Reviews Microbiology 14:7, pages 448-460.
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Elzbieta Lenartowicz, Julita Kesy, Agnieszka Ruszkowska, Marta Soszynska-Jozwiak, Paula Michalak, Walter N. Moss, Douglas H. Turner, Ryszard Kierzek & Elzbieta Kierzek. (2016) Self-Folding of Naked Segment 8 Genomic RNA of Influenza A Virus. PLOS ONE 11:2, pages e0148281.
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Marta Soszynska-Jozwiak, Paula Michalak, Walter N. Moss, Ryszard Kierzek & Elzbieta Kierzek. (2015) A Conserved Secondary Structural Element in the Coding Region of the Influenza A Virus Nucleoprotein (NP) mRNA Is Important for the Regulation of Viral Proliferation. PLOS ONE 10:10, pages e0141132.
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Daniel Marc. (2014) Influenza virus non-structural protein NS1: interferon antagonism and beyond. Journal of General Virology 95:12, pages 2594-2611.
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Marie Gerber, Catherine Isel, Vincent Moules & Roland Marquet. (2014) Selective packaging of the influenza A genome and consequences for genetic reassortment. Trends in Microbiology 22:8, pages 446-455.
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Ruslan A. Soldatov, Svetlana V. Vinogradova & Andrey A. Mironov. (2014) RNASurface: fast and accurate detection of locally optimal potentially structured RNA segments. Bioinformatics 30:4, pages 457-463.
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Ka-To Shum, Jiehua Zhou & John Rossi. (2013) Aptamer-Based Therapeutics: New Approaches to Combat Human Viral Diseases. Pharmaceuticals 6:12, pages 1507-1542.
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Benjamin Mänz, Martin Schwemmle & Linda Brunotte. (2013) Adaptation of Avian Influenza A Virus Polymerase in Mammals To Overcome the Host Species Barrier. Journal of Virology 87:13, pages 7200-7209.
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Claude Loverdo & James O. Lloyd-Smith. (2013) INTERGENERATIONAL PHENOTYPIC MIXING IN VIRAL EVOLUTION. Evolution 67:6, pages 1815-1822.
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Kazuya Ishikawa, Kensaku Maejima, Ken Komatsu, Yugo Kitazawa, Masayoshi Hashimoto, Daisuke Takata, Yasuyuki Yamaji & Shigetou Namba. (2012) Identification and characterization of two novel genomic RNA segments of fig mosaic virus, RNA5 and RNA6. Journal of General Virology 93:7, pages 1612-1619.
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Salvatore F. Priore, Walter N. Moss & Douglas H. Turner. (2012) Influenza A Virus Coding Regions Exhibit Host-Specific Global Ordered RNA Structure. PLoS ONE 7:4, pages e35989.
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Walter N. Moss, Salvatore F. Priore & Douglas H. Turner. (2011) Identification of potential conserved RNA secondary structure throughout influenza A coding regions. RNA 17:6, pages 991-1011.
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