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Research Article

Sperm Protein 17: Clinical Relevance of a Cancer/Testis Antigen, from Contraception to Cancer Immunotherapy, and Beyond

Pages 138-149 | Published online: 10 May 2011

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Michela Colombo, Leonardo Mirandola, Adair Reidy, Natallia Suvorava, Venu Konala, Raffaella Chiaramonte, Fabio Grizzi, Rakhshanda Layeequr Rahman, Marjorie R. Jenkins, Diane D. Nugyen, Scott Dalhbeck, Everardo Cobos, Jose A. Figueroa & Maurizio Chiriva-Internati. (2015) Targeting Tumor Initiating Cells through Inhibition of Cancer Testis Antigens and Notch Signaling: A Hypothesis. International Reviews of Immunology 34:2, pages 188-199.
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F. Arnaboldi, A. Menon, E. Menegola, F. Di Renzo, L. Mirandola, F. Grizzi, J. A. Figueroa, E. Cobos, M. Jenkins, I. Barajon & Maurizio Chiriva-Internati. (2014) Sperm Protein17 is an Oncofetal Antigen: A Lesson From a Murine Model. International Reviews of Immunology 33:5, pages 367-374.
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Maurizio Chiriva-Internati, Apurva Pandey, Radhi Saba, Minji Kim, Charles Saadeh, Tiajani Lukman, Raffaella Chiaramonte, Marjorie Jenkins, Everardo Cobos, Cynthia Jumper & Read Alalawi. (2012) Cancer Testis Antigens: A Novel Target in Lung Cancer. International Reviews of Immunology 31:5, pages 321-343.
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Apurva Pandey, Abhishek Kurup, Arpan Shrivastava, Saba Radhi, Diane. D. Nguyen, Candy Arentz, Nicholas D’Chuna, Fred Hardwick, Martin J. D’Souza, Marjorie Jenkins, Raffaella Chiaramonte, Natalia Platonova, Fabio Grizzi, W. Martin Kast, Everardo Cobos, Rakhshanda Rahman & Maurizio Chiriva-Internati. (2012) Cancer Testes Antigens in Breast Cancer: Biological Role, Regulation, and Therapeutic Applicability. International Reviews of Immunology 31:5, pages 302-320.
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Articles from other publishers (11)

Renzheng Zhang, Chunnian Liang, Xian Guo, Pengjia Bao, Jie Pei, Fude Wu, Mancai Yin, Min Chu & Ping Yan. (2022) Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens). Frontiers in Physiology 13.
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Zewei Tu, Jie Peng, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang & Xingen Zhu. (2022) Sperm Autoantigenic Protein 17 Predicts the Prognosis and the Immunotherapy Response of Cancers: A Pan-Cancer Analysis. Frontiers in Immunology 13.
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Paulette Antiqueo, Rodrigo Zuloaga, Macarena Bastias-Molina, Claudio Meneses, Juan Manuel Estrada, Alfredo Molina & Juan Antonio Valdés. (2021) De novo Assembly and Analysis of Tissue-Specific Transcriptomes of the Edible Red Sea Urchin Loxechinus albus Using RNA-Seq. Biology 10:10, pages 995.
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Runyi Adeline Lam, Tracy Zhijun Tien, Craig Ryan Joseph, Johnathan Xiande Lim, Aye Aye Thike, Jabed Iqbal, Puay Hoon Tan & Joe Poh Sheng Yeong. (2021) Cancer-Testis Antigens in Triple-Negative Breast Cancer: Role and Potential Utility in Clinical Practice. Cancers 13:15, pages 3875.
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Juha‐Pekka Mattila, Leonardo Mirandola & Maurizio Chiriva‐Internati. (2018) Development of a M cell‐targeted microparticulate platform, BSK02™, for oral immunization against the ovarian cancer antigen, sperm protein 17. Journal of Biomedical Materials Research Part B: Applied Biomaterials 107:1, pages 29-36.
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Sue D. Xiang, Kirsty L. Wilson, Anne Goubier, Arne Heyerick & Magdalena Plebanski. (2018) Design of Peptide-Based Nanovaccines Targeting Leading Antigens From Gynecological Cancers to Induce HLA-A2.1 Restricted CD8+ T Cell Responses. Frontiers in Immunology 9.
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Leonardo Mirandola, Elisa Pedretti, Jose A. Figueroa, Raffaella Chiaramonte, Michela Colombo, Caroline Chapman, Fabio Grizzi, Federica Patrinicola, W. Martin Kast, Diane D. Nguyen, Rakhshanda Layeequr Rahman, Naval Daver, Peter Ruvolo, Sean M. Post, Robert S. Bresalier & Maurizio Chiriva-Internati. (2017) Cancer testis antigen Sperm Protein 17 as a new target for triple negative breast cancer immunotherapy. Oncotarget 8:43, pages 74378-74390.
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Yang Liu, Xin Tian, Shenyi Jiang, Xuemei Ren, Fengjie Liu, Jichun Yang, Yanling Chen & Youhong Jiang. (2015) Umbilical cord blood-derived dendritic cells infected by adenovirus for SP17 expression induce antigen-specific cytotoxic T cells against NSCLC cells. Cellular Immunology 298:1-2, pages 18-24.
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Karen B ChapmanMaria J Prendes, Jennifer L Kidd, Hal Sternberg, Michael D West & Joseph Wagner. (2013) Elevated expression of cancer/testis antigen FSIP1 in ER-positive breast tumors. Biomarkers in Medicine 7:4, pages 601-611.
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Jia-xi Song, Wang-li Cao, Fang-qiu Li, Li-ning Shi & Xuan Jia. (2011) Anti-Sp17 monoclonal antibody with antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity activities against human ovarian cancer cells. Medical Oncology 29:4, pages 2923-2931.
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Zu-Juan Zhang, Xin-Hua Chen, Xiao-Hong Chang, Xue Ye, Yi Li & Heng Cui. (2012) Human Embryonic Stem Cells - a Potential Vaccine for Ovarian Cancer. Asian Pacific Journal of Cancer Prevention 13:9, pages 4295-4300.
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