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REVIEW

FOXO1 Transcription Factor: A Critical Effector of the PI3K-AKT Axis in B-Cell Development

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Pages 146-157 | Accepted 07 Jan 2014, Published online: 20 Feb 2014

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Abigail K. Brown & Ashley E. Webb. 2018. Forkhead FOXO Transcription Factors in Development and Disease. Forkhead FOXO Transcription Factors in Development and Disease 165 192 .
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Crossref
Evan C Lien, Christian C Dibble & Alex Toker. (2017) PI3K signaling in cancer: beyond AKT. Current Opinion in Cell Biology 45, pages 62-71.
Crossref
Xinchen Li, Ying Ding, Mengting Zi, Li Sun, Wenjie Zhang, Shun Chen & Yuekang Xu. (2017) CD19, from bench to bedside. Immunology Letters 183, pages 86-95.
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Crossref
Claudia Lentucci, Anna C. Belkina, Carly T. Cederquist, Michelle Chan, Holly E. Johnson, Sherry Prasad, Amanda Lopacinski, Barbara S. Nikolajczyk, Stefano Monti, Jennifer Snyder-Cappione, Bogdan Tanasa, M. Dafne Cardamone & Valentina Perissi. (2017) Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. Journal of Biological Chemistry 292:7, pages 2754-2772.
Crossref
Ewa Jablonska, Patryk Gorniak, Maciej Szydlowski, Tomasz Sewastianik, Emilia Bialopiotrowicz, Anna Polak, Krzysztof Warzocha & Przemyslaw Juszczynski. (2017) MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells. Experimental Hematology 46, pages 56-61.e1.
Crossref
Juber Herrera Uribe, Melania Collado-Romero, Sara Zaldívar-López, Cristina Arce, Rocío Bautista, Ana Carvajal, Susanna Cirera, M. Gonzalo Claros & Juan J. Garrido. (2016) Transcriptional analysis of porcine intestinal mucosa infected with Salmonella Typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum. Veterinary Research 47:1.
Crossref
T Sewastianik, M Szydlowski, E Jablonska, E Bialopiotrowicz, P Kiliszek, P Gorniak, A Polak, M Prochorec-Sobieszek, A Szumera-Cieckiewicz, T S Kaminski, S Markowicz, E Nowak, M A Grygorowicz, K Warzocha & P Juszczynski. (2016) FOXO1 is a TXN- and p300-dependent sensor and effector of oxidative stress in diffuse large B-cell lymphomas characterized by increased oxidative metabolism. Oncogene 35:46, pages 5989-6000.
Crossref
Maria K. Herndon, Nathan C. Law, Elyse M. Donaubauer, Brandon Kyriss & Mary Hunzicker-Dunn. (2016) Forkhead box O member FOXO1 regulates the majority of follicle-stimulating hormone responsive genes in ovarian granulosa cells. Molecular and Cellular Endocrinology 434, pages 116-126.
Crossref
Paul J. Galardy, Tibor Bedekovics & Michelle L. Hermiston. (2016) Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: therapeutic horizons. British Journal of Haematology 173:4, pages 625-636.
Crossref
Maciej SzydlowskiPrzemyslaw KiliszekTomasz SewastianikEwa JablonskaEmilia BialopiotrowiczPatryk GorniakAnna PolakSergiusz MarkowiczEliza NowakMonika A. GrygorowiczMonika Prochorec-SobieszekAnna Szumera-CieckiewiczAgata Malenda, Ewa Lech-Maranda, Krzysztof Warzocha & Przemyslaw Juszczynski. (2016) FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas. Blood 127:6, pages 739-748.
Crossref
Adrian M. Eiden, Shuling Zhang, Joy M. Gary, John K. Simmons & Beverly A. Mock. (2016) Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy. Clinical Cancer Research 22:2, pages 277-283.
Crossref
Kay L. Medina. 2016. Autoimmune Neurology. Autoimmune Neurology 61 76 .
M A Lunning & M R Green. (2015) Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas. Blood Cancer Journal 5:10, pages e361-e361.
Crossref
Kamil Bojarczuk, Malgorzata Bobrowicz, Michal Dwojak, Nina Miazek, Piotr Zapala, Anders Bunes, Marta Siernicka, Maria Rozanska & Magdalena Winiarska. (2015) B-cell receptor signaling in the pathogenesis of lymphoid malignancies. Blood Cells, Molecules, and Diseases 55:3, pages 255-265.
Crossref
Susann Hüttl, Kathrin Kläsener, Michaela Schweizer, Janna Schneppenheim, Hans-Heinrich Oberg, Dieter Kabelitz, Michael Reth, Paul Saftig & Bernd Schröder. (2015) Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells. The Journal of Immunology 195:4, pages 1548-1563.
Crossref
G. Xue, A. Zippelius, A. Wicki, M. Mandala, F. Tang, D. Massi & B. A. Hemmings. (2015) Integrated Akt/PKB Signaling in Immunomodulation and Its Potential Role in Cancer Immunotherapy. JNCI Journal of the National Cancer Institute 107:7, pages djv171-djv171.
Crossref
Dàlia Raïch-Regué, Brian R. Rosborough, Alicia R. Watson, Mandy J. McGeachy, Hēth R. Turnquist & Angus W. Thomson. (2015) mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo. The Journal of Immunology 194:10, pages 4767-4776.
Crossref
James Hagman. 2015. Molecular Biology of B Cells. Molecular Biology of B Cells 35 53 .
Alhassan Hameedaldeen, Jian Liu, Angelika Batres, Gabrielle Graves & Dana Graves. (2014) FOXO1, TGF-β Regulation and Wound Healing. International Journal of Molecular Sciences 15:9, pages 16257-16269.
Crossref

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