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International Reviews of Immunology Volume 34, 2015 - Issue 2
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Tertiary Lymphoid Tissue in the Tumor Microenvironment: From Its Occurrence to Immunotherapeutic Implications

Giuseppe Di CaroDepartment of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
,
Giovanni Francesco CastinoDepartment of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
,
Francesca BergomasDepartment of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
,
Nina CorteseDepartment of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
,
Maurizio Chiriva-InternatiDepartment of Internal Medicine, Division of Hematology/Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
,
Fabio GrizziDepartment of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
,
Alberto MantovaniDepartment of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
&
Federica MarchesiDepartment of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, ItalyCorrespondence[email protected]
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Pages 123-133 | Accepted 09 Feb 2015, Published online: 22 Apr 2015

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Giovanni Francesco Castino, Nina Cortese, Giovanni Capretti, Simone Serio, Giuseppe Di Caro, Rossana Mineri, Elena Magrini, Fabio Grizzi, Paola Cappello, Francesco Novelli, Paola Spaggiari, Massimo Roncalli, Cristina Ridolfi, Francesca Gavazzi, Alessandro Zerbi, Paola Allavena & Federica Marchesi. (2016) Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma. OncoImmunology 5:4.
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Articles from other publishers (19)

Qianqian Zhang & Suhui Wu. (2023) Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response. Frontiers in Immunology 13.
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Yan Lin, De-Xia Kong & You-Ni Zhang. (2022) Does the Microbiota Composition Influence the Efficacy of Colorectal Cancer Immunotherapy?. Frontiers in Oncology 12.
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Ilaria Grazia Zizzari, Alessandra Di Filippo, Andrea Botticelli, Lidia Strigari, Angelina Pernazza, Emma Rullo, Maria Gemma Pignataro, Alessio Ugolini, Fabio Scirocchi, Francesca Romana Di Pietro, Ernesto Rossi, Alain Gelibter, Giovanni Schinzari, Giulia D'Amati, Aurelia Rughetti, Paolo Marchetti, Marianna Nuti & Chiara Napoletano. (2022) Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer. Clinical Cancer Research 28:5, pages 1027-1037.
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Marie Muller, Vincent Haghnejad, Marion Schaefer, Guillaume Gauchotte, Bénédicte Caron, Laurent Peyrin-Biroulet, Jean-Pierre Bronowicki, Cindy Neuzillet & Anthony Lopez. (2022) The Immune Landscape of Human Pancreatic Ductal Carcinoma: Key Players, Clinical Implications, and Challenges. Cancers 14:4, pages 995.
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Meng Qin, Ying Jin & Ling-Ya Pan. (2021) Tertiary lymphoid structure and B‑cell‑related pathways: A potential target in tumor immunotherapy (Review). Oncology Letters 22:6.
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Jennifer L Vella, Aleksey Molodtsov, Christina V Angeles, Bruce R Branchini, Mary Jo Turk & Yina H Huang. (2021) Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells. Life Science Alliance 4:10, pages e202101056.
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Wendi Kang, Zhichao Feng, Jianwei Luo, Zhenhu He, Jun Liu, Jianzhen Wu & Pengfei Rong. (2021) Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies. Frontiers in Immunology 12.
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Qunxing Li, Xiangqi Liu, Dikan Wang, Yanqiong Wang, Huanzi Lu, Shuqiong Wen, Juan Fang, Bin Cheng & Zhi Wang. (2020) Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma. International Journal of Oral Science 12:1.
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Daniela Bruni, Helen K. Angell & Jérôme Galon. (2020) The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nature Reviews Cancer 20:11, pages 662-680.
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Dongmei Ai, Gang Liu, Xiaoxin Li, Yuduo Wang & Man Guo. (2020) Calculation of immune cell proportion from batch tumor gene expression profile based on support vector regression. Journal of Bioinformatics and Computational Biology 18:05, pages 2050030.
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Xiaoting Pan, Heyun Tao, Mengjun Nie, Yuanjie Liu, Pan Huang, Shenlin Liu, Wei Sun, Jian Wu, Ting Ma, Anwei Dai, Jianwei Lu, Baorui Liu, Xi Zou & Qingmin Sun. (2020) A clinical study of traditional Chinese medicine prolonging the survival of advanced gastric cancer patients by regulating the immunosuppressive cell population. Medicine 99:16, pages e19757.
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Pascal Jézéquel, Olivier Kerdraon, Hubert Hondermarck, Catherine Guérin-Charbonnel, Hamza Lasla, Wilfried Gouraud, Jean-Luc Canon, Andrea Gombos, Florence Dalenc, Suzette Delaloge, Jérôme Lemonnier, Delphine Loussouarn, Véronique Verrièle & Mario Campone. (2019) Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications. Breast Cancer Research 21:1.
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Eun Kyung Kim, Yoon Ah Cho, Mi-kyoung Seo, Hyunmi Ryu, Byoung Chul Cho, Yoon Woo Koh & Sun Och Yoon. (2019) NOVA1 induction by inflammation and NOVA1 suppression by epigenetic regulation in head and neck squamous cell carcinoma. Scientific Reports 9:1.
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Liangbin Lin, Xiang Hu, Huiyuan Zhang & Hongbo Hu. (2019) Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy. Frontiers in Immunology 10.
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Jakob Nikolas Kather & Niels Halama. (2019) Harnessing the innate immune system and local immunological microenvironment to treat colorectal cancer. British Journal of Cancer 120:9, pages 871-882.
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Marcella Tazzari, Silvia Brich, Alessandra Tuccitto, Fabio Bozzi, Valeria Beretta, Rosalin D. Spagnuolo, Tiziana Negri, Silvia Stacchiotti, Marcello Deraco, Dario Baratti, Chiara Camisaschi, Antonello Villa, Barbara Vergani, Licia Rivoltini, Silvana Pilotti & Chiara Castelli. (2018) Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Journal of Immunology Research 2018, pages 1-13.
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Wolf H. Fridman, Laurence Zitvogel, Catherine Sautès–Fridman & Guido Kroemer. (2017) The immune contexture in cancer prognosis and treatment. Nature Reviews Clinical Oncology 14:12, pages 717-734.
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Eun Kyung Kim, Sun Och Yoon, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You-Jin Jang, Soon Won Hong, Seung Ho Choi & Woo Ick Yang. (2016) Implications of NOVA1 suppression within the microenvironment of gastric cancer: association with immune cell dysregulation. Gastric Cancer 20:3, pages 438-447.
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Sun Och Yoon, Eun Kyung Kim, Mira Lee, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You-Jin Jang, Soon Won Hong, Seung Ho Choi & Woo Ick Yang. (2015) NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal . Oncotarget 7:3, pages 2475-2495.
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