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Chimeric Antigen Receptor Engineering: A Right Step in the Evolution of Adoptive Cellular Immunotherapy

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Pages 154-187 | Accepted 09 Feb 2015, Published online: 22 Apr 2015

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Crossref
Russell E. VanceMichael J. EichbergDaniel A. PortnoyDavid H. Raulet. (2017) Listening to each other: Infectious disease and cancer immunology. Science Immunology 2:7.
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Crossref
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Crossref
A. Tsun, X. N. Miao, C. M. Wang & D. C. Yu. 2016. Progress in Cancer Immunotherapy. Progress in Cancer Immunotherapy 241 283 .

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