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International Reviews of Immunology Volume 9, 1992 - Issue 2
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Original Article

Molecular Basis for the Autoreactivity Against Thyroid Stimulating Hormone Receptor

Leonard D. Kohn Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Shinji Kosugi Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Toshiaki Ban Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Motoyasu Saji Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Shoichiro Ikuyama Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Cesidio Giuliani Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Akinari Hidaka Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Hiroki Shimura Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Takashi Akamizu Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
Kazuo Tahara Cell Regulation Section, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
,
John Moriarty Department of Microbiology, The University of Texas Medical Branch at Galveston, Galveston, Texas, 77550, USA
,
Bellur S. Prabhakar Department of Microbiology, The University of Texas Medical Branch at Galveston, Galveston, Texas, 77550, USA
&
Dinah S. Singer Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
 show all
Pages 135-165 | Received 13 Jul 1992, Published online: 10 Jul 2009

Citations (32)

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Read on this site (2)

Leonard D. Kohn & Norikazu Harii. (2003) Thyrotropin Receptor Autoantibodies (TSHRAbs): Epitopes, Origins and Clinical Significance. Autoimmunity 36:6-7, pages 331-337.
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Neelam M. Wagle, John S. Dallas, Gattadahalli S. Seetharamaiah, Ji-Lao Fan, Rajesh K. Desai, Omeed Memar, Srinivasan Rajaraman & Bellur S. Prabhakar. (1994) Induction of Hyperthyroxinemia in Balb/C but not in Several Other Strains of Mice. Autoimmunity 18:2, pages 103-112.
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Articles from other publishers (30)

Robert W. Figliozzi, Feng Chen & Shaochung V. Hsia. (2017) Reversing thyroid hormone mediated repression of a HSV-1 promoter via computationally guided mutagenesis. Journal of Cell Science.
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Min Hee LeeJung Uee Lee, Kyong Hye JoungYong Kyung KimMin Jeong RyuSeong Eun LeeSoung Jung KimHyo Kyun ChungMin Jeong ChoiJoon Young ChangSang-Hee Lee, Gi Ryang Kweon, Hyun Jin KimKoon Soon KimSeong-Min Kim, Young Suk JoJeongwon Park, Sheue-Yann Cheng & Minho Shong. (2015) Thyroid Dysfunction Associated With Follicular Cell Steatosis in Obese Male Mice and Humans. Endocrinology 156:3, pages 1181-1193.
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Keiichi KamijoHiroshi MurayamaTakahiro UzuKazuyoshi TogashiGeorge J. Kahaly. (2010) A Novel Bioreporter Assay for Thyrotropin Receptor Antibodies Using a Chimeric Thyrotropin Receptor (Mc4) Is More Useful in Differentiation of Graves' Disease from Painless Thyroiditis Than Conventional Thyrotropin-Stimulating Antibody Assay Using Porcine Thyroid Cells. Thyroid 20:8, pages 851-856.
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Bellur S. Prabhakar, Rebecca S. Bahn & Terry J. Smith. (2003) Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy. Endocrine Reviews 24:6, pages 802-835.
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Alan N Elias, Vandana S Nanda & Ronald J Barr. (2003) CD1a expression in psoriatic skin following treatment with propylthiouracil, an antithyroid thioureylene. BMC Dermatology 3:1.
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A Alnaqdy, A Alfahdi, M Alkobaisi & GZ Kaminski. (2003) Prevalence of Autoantibodies in Patients with Hepatitis C Virus Infection in Oman. Annals of Saudi Medicine 23:3-4, pages 127-131.
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Chan Hyun Na, Mi Hwa Lee, Bo Youn Cho & Chi-Bom Chae. (2003) A Method for Identification of the Peptides That Bind to a Clone of Thyroid-Stimulating Antibodies in the Serum of Graves’ Disease Patients. The Journal of Clinical Endocrinology & Metabolism 88:4, pages 1570-1576.
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Peter P. A. Smyth & Roisin M. Dwyer. (2002) The sodium iodide symporter and thyroid disease. Clinical Endocrinology 56:4, pages 427-429.
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Takashi Akamizu. (2001) Antithyrotropin Receptor Antibody: An Update. Thyroid 11:12, pages 1123-1134.
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Won Bae Kim, Hyun Kyung Chung, Young Joo Park, Do Joon Park, Hong Kyu Lee & Bo Youn Cho. (2001) Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies. The Korean Journal of Internal Medicine 16:3, pages 187-200.
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Yoshiyuki Hattori, Takashi Akamizu, Misa Saijo, Naotetsu Kanamoto, Kenji Moriyama, Nobuyuki Ito & Kazuwa Nakao. (2001) Characterization of the secretable ectodomain of thyrotropin receptor produced by the recombinant baculovirus system. Molecular and Cellular Endocrinology 182:2, pages 165-174.
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Chang Hyun Byun, June Young ParkTakashi Akamizu & Chi-Bom Chae. (2001) Identification of the Peptides That Inhibit the Function of Human Monoclonal Thyroid-Stimulating Antibodies from Phage-Displayed Peptide Library1. The Journal of Clinical Endocrinology & Metabolism 86:7, pages 3311-3318.
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Viktória Kaczur, Mária Takács, Csaba Szalai, András Falus, Zsuzsa Nagy, György Berencsi & Csaba Balázs. (2001) Analysis of the genetic variability of the 1st (CCC/ACC, P52T) and the 10th exons (bp 1012–1704) of the TSH receptor gene in Graves’ disease. European Journal of Immunogenetics 27:1, pages 17-23.
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June Young Park, Jiae Lee, Bo Youn Cho & Chi-Bom Chae. (1999) Different bioactivities of human thyrotropin receptors with different signal peptides. Molecular and Cellular Endocrinology 147:1-2, pages 133-142.
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Motoyasu Saji, Minho Shong, Giorgio Napolitano, Lisa A. Palmer, Shin-Ichi Taniguchi, Masayuki Ohmori, Masanori Ohta, Koichi Suzuki, Susan L. Kirshner, Cesidio Giuliani, Dinah S. Singer & Leonard D. Kohn. (1997) Regulation of Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells. Journal of Biological Chemistry 272:32, pages 20096-20107.
Crossref
Johan Rönnelid, Iva Gunnarsson, Kristina Nilsson-Ekdahl & Bo Nilsson. (1997) Correlation between Anti-C1q and Immune Conglutinin Levels, but not between Levels of Antibodies to the Structurally Related Autoantigens C1q and Type II Collagen in SLE or RA. Journal of Autoimmunity 10:4, pages 415-423.
Crossref
Won Bae KimHyun Kyung ChungHong Kyu LeeLeonard D. KohnKazuo Tahara & Bo Youn Cho. (1997) Changes in Epitopes for Thyroid-Stimulating Antibodies in Graves’ Disease Sera During Treatment of Hyperthyroidism: Therapeutic Implications1. The Journal of Clinical Endocrinology & Metabolism 82:6, pages 1953-1959.
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YUKIHIKO WATANABE, KAZUO TAHARA, AIZAN HIRAI, HISATO TADA, LEONARD D. KOHN & NOBUYUKI AMINO. (1997) Subtypes of Anti-TSH Receptor Antibodies Classified by Various Assays Using CHO Cells Expressing Wild-Type or Chimeric Human TSH Receptor. Thyroid 7:1, pages 13-19.
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Sai A. Patibandla & Bellur S. Prabhakar. (1996) Autoimmunity to the thyroid stimulating hormone receptor. Advances in Neuroimmunology 6:4, pages 347-357.
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John S. Dallas & Bellur S. Prabhakar. 1996. Endocrine Methods. Endocrine Methods 299 318 .
Hideo Sugawa, Y. Ueda, T. Akamizu, S. Kosugi, J. Okuda, C. Ohta, Y. Kiho & T. Mori. (2014) Statistical analysis of functional region(s) of the TSH receptor. Journal of Endocrinological Investigation 18:9, pages 710-717.
Crossref
TAKASHI AKAMIZU, YOSHIMICHI UEDA, LI HUA, JYOJI OKUDA & TORU MORI. (1995) Establishment and Characterization of an Antihuman Thyrotropin (TSH) Receptor-Specific CD4 + T Cell Line from a Patient with Graves' Disease: Evidence for Multiple T Cell Epitopes on the TSH Receptor Including the Transmembrane Domain . Thyroid 5:4, pages 259-264.
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Cesidio Giuliani, Motoyasu Saji, Giorgio Napolitano, Lisa A. Palmer, Shin-Ichi Taniguchi, Minho Shong, Dinah S. Singer & Leonard D. Kohn. (1995) Hormonal Modulation of Major Histocompatibility Complex Class I Gene Expression Involves an Enhancer A-binding Complex Consisting of Fra-2 and the p50 Subunit of NF-κB. Journal of Biological Chemistry 270:19, pages 11453-11462.
Crossref
Leonard D. Kohn, Hiroki Shimura, Yoshie Shimura, Akinari Hidaka, Cesidio Giuliani, Giorgio Napolitano, Masayuki Ohmori, Giovanna Laglia & Motoyasu Saji. 1995. 287 384 .
Tiina P. Iismaa, Trevor J. Biden & John ShineTiina P. Iismaa, Trevor J. Biden & John Shine. 1995. G Protein-Coupled Receptors. G Protein-Coupled Receptors 135 169 .
Klaus-Dieter Kohnert, Siegfried Krabbe & Wieland Meng. (1994) Immunohistochemical characterization of monoclonal antibodies directed against the TSH receptor. Acta Histochemica 96:2, pages 175-180.
Crossref
AKINARI HIDAKA, TOSHIAKI BAN, NIRMAL S. PANESAR, TAKASHI MINEGISHI, LEONARD D. KOHN & KAZUO TAHARA. (1994) Thyrotropin Stimulation of the Lutropin/Choriogonadotropin Receptor: Different Sites Mediate Agonist Activity and High Affinity Binding. Thyroid 4:4, pages 447-457.
Crossref
Motoyasu Saji, Shoichiro Ikuyama, Hiroki Shimura, Toshiaki Ban, Shinji Kosugi, Akinari Hidaka, Fumikazu Okajima, Yoshie Shimura, Cesidio Giuliani, Giorgio Napolitano, Kazuo Tahara, Takashi Akamizu & Leonard D. Kohn. 1994. Glycoprotein Hormones. Glycoprotein Hormones 177 216 .
Leonard D. Kohn & Rudolf C. Kuppers. (1992) Thyrotropin receptor autoantibodies in thyroid autoimmune disease: Epitopes and origin. Clinical Immunology Newsletter 12:12, pages 169-181.
Crossref
Shinji Kosugi, Toshiaki Ban, Takashi Akamizu & Leonard D. Kohn. (1992) Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: Effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies. Biochemical and Biophysical Research Communications 189:3, pages 1754-1762.
Crossref

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