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International Reviews of Immunology Volume 13, 1995 - Issue 2
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Original Article

Central Tolerance of T Cells

Jonathan Sprent Department of Immunology, IMM4, The Scripps Research Institute, 10666 N. Torrey Pines Road, La Jolla, CaliforniaCorrespondence[email protected]
Pages 95-105 | Received 28 Apr 1995, Published online: 10 Jul 2009

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Ashleigh S Boyd & Paul J Fairchild. (2010) Approaches for immunological tolerance induction to stem cell-derived cell replacement therapies. Expert Review of Clinical Immunology 6:3, pages 435-448.
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Ming-Hua Zheng, Dian-Na Gu, Martin Braddock, Andrew J Leishman, Chang Jin, Jin-Sheng Wen, Yue-Wen Gong & Yong-Ping Chen. (2008) CD4+CD25+ regulatory T cells: a therapeutic target for liver diseases. Expert Opinion on Therapeutic Targets 12:3, pages 313-326.
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J. F. A. P. Miller. (1995) Autoantigen-induced Deletion of Peripheral Self-reactive T Cells. International Reviews of Immunology 13:2, pages 107-114.
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J. F.A.P. Miller. (1995) Introduction. International Reviews of Immunology 13:2, pages i-ii.
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Franziska Füchsl & Angela M. Krackhardt. (2022) Paving the Way to Solid Tumors: Challenges and Strategies for Adoptively Transferred Transgenic T Cells in the Tumor Microenvironment. Cancers 14:17, pages 4192.
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Hisato Iriki, Hayato Takahashi, Naoko WadaHisashi NomuraMiho MukaiAki KamataHiromi ItoJun YamagamiTakeshi Matsui, Yutaka KurebayashiSetsuko Mise-OmataHiroshi NishimasuOsamu Nureki, Akihiko YoshimuraShohei Hori & Masayuki Amagai. (2021) Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus. Proceedings of the National Academy of Sciences 118:49.
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Ayano Toyoda, Toshinori Kozaki, Kazuo Ishii, Momoka Taniishi, Makoto Hattori, Hiroshi Matsuda & Tadashi Yoshida. (2020) Comprehensive analysis of DNA methylation and gene expression in orally tolerized T cells. PLOS ONE 15:2, pages e0229042.
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Maria Isabel Tores, Miguel Angel López-Casado, Candelaria Ponce de León, Pedro Lorite & Teresa Palomeque. 2017. Physiology and Pathology of Immunology. Physiology and Pathology of Immunology.
Yusuke Yoshioka, Toshinori Kozaki, Kazuo Ishii, Ayano Toyoda, Makoto Hattori & Tadashi Yoshida. (2017) Comprehensive analysis of epigenetically regulated genes in anergic T cells. Cellular Immunology 311, pages 71-79.
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William H. Peranteau. (2014) In utero hematopoietic cell transplantation: induction of donor specific immune tolerance and postnatal transplants. Frontiers in Pharmacology 5.
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Samanthi Narayanan & David M. Kranz. (2013) The Same Major Histocompatibility Complex Polymorphism Involved in Control of HIV Influences Peptide Binding in the Mouse H-2Ld System. Journal of Biological Chemistry 288:44, pages 31784-31794.
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Rodolfo Thomé, Adriel S. Moraes, André Luis Bombeiro, Alessandro dos Santos Farias, Carolina Francelin, Thiago Alves da Costa, Rosária Di Gangi, Leonilda Maria Barbosa dos Santos, Alexandre Leite Rodrigues de Oliveira & Liana Verinaud. (2013) Chloroquine Treatment Enhances Regulatory T Cells and Reduces the Severity of Experimental Autoimmune Encephalomyelitis. PLoS ONE 8:6, pages e65913.
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Robert Katamay & Robert B. Nussenblatt. 2013. Retina. Retina 579 589 .
Adam D. Griesemer, Eric C. Sorenson & Mark A. Hardy. (2010) The Role of the Thymus in Tolerance. Transplantation 90:5, pages 465-474.
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Mahesh Choolani, Jerry Chan & Nicholas M. Fisk. (2010) Fetal therapy: 2020 and beyond. Prenatal Diagnosis 30:7, pages 699-701.
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Joseph Lustgarten & Noweeda Mirza. 2009. Handbook on Immunosenescence. Handbook on Immunosenescence 1189 1216 .
Jerry Chan, Sailesh Kumar & Nicholas M. Fisk. (2008) First trimester embryo-fetoscopic and ultrasound-guided fetal blood sampling for ex vivo viral transduction of cultured human fetal mesenchymal stem cells. Human Reproduction 23:11, pages 2427-2437.
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Ana Lucia Dominguez & Joseph Lustgarten. (2008) Implications of Aging and Self-Tolerance on the Generation of Immune and Antitumor Immune Responses. Cancer Research 68:13, pages 5423-5431.
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Demetri Merianos, Todd Heaton & Alan W. Flake. (2008) In Utero Hematopoietic Stem Cell Transplantation: Progress toward Clinical Application. Biology of Blood and Marrow Transplantation 14:7, pages 729-740.
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C. KAMATÉ, P.J. LENTING, H.M. VAN DEN BERG & T. MUTIS. (2007) Depletion of CD4+/CD25high regulatory T cells may enhance or uncover factor VIII‐specific T‐cell responses in healthy individuals. Journal of Thrombosis and Haemostasis 5:3, pages 611-613.
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Christian Becker, Sabine Stoll, Tobias Bopp, Edgar Schmitt & Helmut Jonuleit. (2006) Regulatory T cells: present facts and future hopes. Medical Microbiology and Immunology 195:3, pages 113-124.
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William H Peranteau & Alan W Flake. (2006) In-utero tolerance. Current Opinion in Organ Transplantation 11:4, pages 353-359.
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Phyllis-Jean Linton, Joseph Lustgarten & Marilyn Thoman. (2006) T cell function in the aged: Lessons learned from animal models. Clinical and Applied Immunology Reviews 6:2, pages 73-97.
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Wee-Kiak Lim & Robert B. Nussenblatt. 2006. Retina. Retina 253 263 .
Lucian Visan, Ioana A. Visan, Andreas Weishaupt, Harald H. Hofstetter, Klaus V. Toyka, Thomas Hünig & Ralf Gold. (2004) Tolerance Induction by Intrathymic Expression of P0. The Journal of Immunology 172:3, pages 1364-1370.
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Alan W. Flake & Esmail D. Zanjani. 2003. Thomas' Hematopoietic Cell Transplantation. Thomas' Hematopoietic Cell Transplantation 565 575 .
Elise Chiffoleau, Patrick T. Walsh & Laurence Turka. (2003) Apoptosis and transplantation tolerance. Immunological Reviews 193:1, pages 124-145.
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Ed Palmer. (2003) Negative selection — clearing out the bad apples from the T-cell repertoire. Nature Reviews Immunology 3:5, pages 383-391.
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Jing Wang & Yang-Xin Fu. (2003) LIGHT (a Cellular Ligand for Herpes Virus Entry Mediator and Lymphotoxin Receptor)-Mediated Thymocyte Deletion Is Dependent on the Interaction Between TCR and MHC/Self-Peptide. The Journal of Immunology 170:8, pages 3986-3993.
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Jonathan Sprent & Hidehiro Kishimoto. (2002) The thymus and negative selection. Immunological Reviews 185:1, pages 126-135.
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Mark F. Pittenger, Robert J. Deans & Alan M. Flake. 2002. Methods of Tissue Engineering. Methods of Tissue Engineering 461 469 .
G. Kögler. 2002. Molekulare Medizin in der Frauenheilkunde. Molekulare Medizin in der Frauenheilkunde 165 182 .
M.F. McCarty. (2001) Upregulation of lymphocyte apoptosis as a strategy for preventing and treating autoimmune disorders: a role for whole-food vegan diets, fish oil and dopamine agonists. Medical Hypotheses 57:2, pages 258-275.
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Jonathan Sprent & Hidehiro Kishimoto. (2001) The thymus and central tolerance. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356:1409, pages 609-616.
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Ouafae Kecha-Kamoun, Imane Achour, Henri Martens, Julien Collette, Pierre J. Lefebvre, Dale L. Greiner & Vincent Geenen. (2001) Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes. Diabetes/Metabolism Research and Reviews 17:2, pages 146-152.
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Holger N. Lode, Rong Xiang, Ursula Pertl, Elisabeth Förster, Stephen P. Schoenberger, Stephen D. Gillies & Ralph A. Reisfeld. (2000) Melanoma immunotherapy by targeted IL-2 depends on CD4+ T-cell help mediated by CD40/CD40L interaction. Journal of Clinical Investigation 105:11, pages 1623-1630.
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Hidehiro Kishimoto & Jonathan Sprent. (2000) The Thymus and Central Tolerance. Clinical Immunology 95:1, pages S3-S7.
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Gérald J Prud'homme & Ciriaco A Piccirillo. (2000) The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases. Journal of Autoimmunity 14:1, pages 23-42.
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Alan W. FlakeEsmail D. Zanjani. (1999) In Utero Hematopoietic Stem Cell Transplantation: Ontogenic Opportunities and Biologic Barriers. Blood 94:7, pages 2179-2191.
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Hidehiro Kishimoto & Jonathan Sprent. (1999) Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes. The Journal of Experimental Medicine 190:1, pages 65-74.
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Jiaren Sun, Bernadette Dirden-Kramer, Komei Ito, Peter B. Ernst & Nancy Van Houten. (1999) Antigen-Specific T Cell Activation and Proliferation During Oral Tolerance Induction. The Journal of Immunology 162:10, pages 5868-5875.
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ALAN W. FLAKE & ESMAIL D. ZANJANI. (1998) In Utero Transplantation for Thalassemia. Annals of the New York Academy of Sciences 850:1 COOLEY'S ANEM, pages 300-311.
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JONATHAN SPRENT & HIDEHIRO KISHIMOTO. (1998) T Cell Tolerance and the Thymusa. Annals of the New York Academy of Sciences 841:1 MYASTHENIA GR, pages 236-245.
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Jonathan Sprent & Charles D. Surh. 1998. Encyclopedia of Immunology. Encyclopedia of Immunology 2304 2309 .
Hans-Georg Rammensee, Jutta Bachmann & Stefan StevanovićHans-Georg Rammensee, Jutta Bachmann & Stefan Stevanović. 1997. MHC Ligands and Peptide Motifs. MHC Ligands and Peptide Motifs 371 447 .
Jonathan Sprent, Hidehiro Kishimoto, Zeling Cai, Charles D. Surh, Anders Brunmark, Michael R. Jackson & Per A. Peterson. 1996. Mechanisms of Lymphocyte Activation and Immune Regulation VI. Mechanisms of Lymphocyte Activation and Immune Regulation VI 191 198 .

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