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International Reviews of Immunology Volume 16, 1998 - Issue 3-4
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Original Article

Leukemia Inhibitory Factor: Part of a Large Ingathering Family

Jean-Luc Taupin University of Bordeaux, 2, CNRS-UMR, 5540, Bordeaux, France
,
Vincent Pitard University of Bordeaux, 2, CNRS-UMR, 5540, Bordeaux, France
,
Julie Dechanet University of Bordeaux, 2, CNRS-UMR, 5540, Bordeaux, France
,
Veronique Miossec University of Bordeaux, 2, CNRS-UMR, 5540, Bordeaux, France
,
Norbert Gualde University of Bordeaux, 2, CNRS-UMR, 5540, Bordeaux, France
&
Jean-Francois Moreau University of Bordeaux, 2, CNRS-UMR, 5540, Bordeaux, France
Pages 397-426 | Received 20 Sep 1996, Published online: 10 Jul 2009

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Pankaj Suman, Sudha Saryu Malhotra & Satish Kumar Gupta. (2013) LIF-STAT signaling and trophoblast biology. JAK-STAT 2:4.
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Howard Yu, Sahil Zaveri, Meshach Pillai, Harsha Taluru, Michael Schaible, Sahil Chaddha, Asad Ahmed, Said Tfaili & Patrick Geraghty. (2023) The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases. Journal of Respiration 3:2, pages 86-100.
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Robin M. Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, AJ Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin & Joan Seoane. (2023) Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment. Clinical Cancer Research 29:4, pages 791-804.
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E. Borazanci, A.M. Schram, E. Garralda, I. Brana, M. Vieito Villar, A. Spreafico, M. Oliva, N.J. Lakhani, K. Hoffman, R.M. Hallett, D. Maetzel, F. Hua, J. Hilbert, P. Giblin, J. Anido, A. Kelly, P.J. Vickers, R. Wasserman, J. Seoane, L.L. Siu, D.M. Hyman, D.V. Hoff & J. Tabernero. (2022) Phase I, first-in-human study of MSC-1 (AZD0171), a humanized anti-leukemia inhibitory factor monoclonal antibody, for advanced solid tumors. ESMO Open 7:4, pages 100530.
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Ruijiang Zeng, Chang Tong & Xiangyang Xiong. (2022) The Molecular Basis and Therapeutic Potential of Leukemia Inhibitory Factor in Cancer Cachexia. Cancers 14:12, pages 2955.
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Shahid Husain, Syed A. H. Zaidi, Sudha Singh, Wendy Guzman & Shikhar Mehrotra. (2021) Reduction of Neuroinflammation by δ-Opioids Via STAT3-Dependent Pathway in Chronic Glaucoma Model. Frontiers in Pharmacology 12.
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Andrea M. Patterson, Tong Wu, Hui Lin Chua, Carol H. Sampson, Alexa Fisher, Pratibha Singh, Theresa A. Guise, Hailin Feng, Jessica Muldoon, Laura Wright, P. Artur Plett, Louis M. Pelus & Christie M. Orschell. (2020) Optimizing and Profiling Prostaglandin E2 as a Medical Countermeasure for the Hematopoietic Acute Radiation Syndrome. Radiation Research 195:2.
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Meritxell Vendrell-Flotats, Tania García-Martínez, Iris Martínez-Rodero, Manel Lopez-Bejar, Jonathan LaMarre, Marc Yeste & Teresa Mogas. (2020) In Vitro Maturation with Leukemia Inhibitory Factor Prior to the Vitrification of Bovine Oocytes Improves Their Embryo Developmental Potential and Gene Expression in Oocytes and Embryos. International Journal of Molecular Sciences 21:19, pages 7067.
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Carolina Blüguermann, Leonardo Romorini, Denis Evseenko, Ximena Garate, Gabriel Neiman, Gustavo Emilio Sevlever, María Elida Scassa & Santiago Gabriel Miriuka. (2017) Leukemia Inhibitory Factor Increases Survival of Pluripotent Stem Cell-Derived Cardiomyocytes. Journal of Cardiovascular Translational Research 11:1, pages 1-13.
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Rossella Russo, Giuseppe Pasquale Varano, Annagrazia Adornetto, Carlo Nucci, Maria Tiziana Corasaniti, Giacinto Bagetta & Luigi Antonio Morrone. (2016) Retinal ganglion cell death in glaucoma: Exploring the role of neuroinflammation. European Journal of Pharmacology 787, pages 134-142.
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Laure Humbert, Mostafa Ghozlan, Lucie Canaff, Jun Tian & Jean-Jacques Lebrun. (2015) The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma. BMC Cancer 15:1.
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Ying Yu, Yumei Wang, Yangyang Niu, Lanjun Fu, Y. Eugene Chin & Chen Yu. (2015) Leukemia inhibitory factor attenuates renal fibrosis through Stat3-miR-29c. American Journal of Physiology-Renal Physiology 309:7, pages F595-F603.
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Pavel Ostasov, Zbynek Houdek, Jan Cendelin & Milena Kralickova. (2015) Role of leukemia inhibitory factor in the nervous system and its pathology. Reviews in the Neurosciences 26:4.
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Emma L WilliamsChristopher J Edwards, Cyrus Cooper & Richard OC Oreffo. (2012) Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine. Regenerative Medicine 7:4, pages 551-570.
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Marie-Emmanuelle Mathieu, Claire Saucourt, Virginie Mournetas, Xavier Gauthereau, Nadine Thézé, Vincent Praloran, Pierre Thiébaud & Hélène Bœuf. (2011) LIF-Dependent Signaling: New Pieces in the Lego. Stem Cell Reviews and Reports 8:1, pages 1-15.
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Farhad Mashayekhi & Zivar Salehi. (2011) Expression of leukemia inhibitory factor in the cerebrospinal fluid of patients with multiple sclerosis. Journal of Clinical Neuroscience 18:7, pages 951-954.
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SM Buckley & C Verfaillie. 2011. Blood and Bone Marrow Pathology. Blood and Bone Marrow Pathology 63 76 .
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Marco Leibinger, Adrienne Müller, Anastasia Andreadaki, Thomas G. Hauk, Matthias Kirsch & Dietmar Fischer. (2009) Neuroprotective and Axon Growth-Promoting Effects following Inflammatory Stimulation on Mature Retinal Ganglion Cells in Mice Depend on Ciliary Neurotrophic Factor and Leukemia Inhibitory Factor. The Journal of Neuroscience 29:45, pages 14334-14341.
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L Mohamet, J K Heath & S J Kimber. (2009) Determining the LIF-sensitive period for implantation using a LIF-receptor antagonist. REPRODUCTION 138:5, pages 827-836.
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P. Rodrigues, D. Limback, L.K. McGinnis, C.E. Plancha & D.F. Albertini. (2008) Oogenesis: Prospects and challenges for the future. Journal of Cellular Physiology 216:2, pages 355-365.
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A.A. Fouladi-Nashta, L. Mohamet, J.K. Heath & S.J. Kimber. (2008) Interleukin 1 Signaling Is Regulated by Leukemia Inhibitory Factor (LIF) and Is Aberrant in Lif−/− Mouse Uterus1. Biology of Reproduction 79:1, pages 142-153.
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EUGENE M. JOHNSONJR.JR. & MARK H. TUSZYNSKI. 2008. CNS Regeneration. CNS Regeneration 95 144 .
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Tom Y.H. Wu & Sheng Ding. (2006) Applying chemical tools to the discovery of novel regenerative medicine. Drug Discovery Today: Technologies 3:3, pages 255-260.
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D Duval, M Malaisé, B Reinhardt, C Kedinger & H Boeuf. (2003) A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells. Cell Death & Differentiation 11:3, pages 331-341.
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Yunzeng ZouHiroyuki TakanoMiho MizukamiHiroshi AkazawaYingjie QinHaruhiro TokoMasaya SakamotoTohru MinaminoToshio NagaiIssei Komuro. (2003) Leukemia Inhibitory Factor Enhances Survival of Cardiomyocytes and Induces Regeneration of Myocardium After Myocardial Infarction. Circulation 108:6, pages 748-753.
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Donald Metcalf. (2008) The Unsolved Enigmas of Leukemia Inhibitory Factor. STEM CELLS 21:1, pages 5-14.
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Ann B. Vernallis. 2003. Encyclopedia of Hormones. Encyclopedia of Hormones 578 585 .
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Feng Wang, JoAnn Trial, Abhinav Diwan, Feng Gao, Holly Birdsall, Mark Entman, Peter Hornsby, Natarajan Sivasubramaniam & Douglas Mann. (2002) Regulation of Cardiac Fibroblast Cellular Function by Leukemia Inhibitory Factor. Journal of Molecular and Cellular Cardiology 34:10, pages 1309-1316.
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G Lisignoli, A Piacentini, S Toneguzzi, F Grassi, B Cocchini, A Ferruzzi, G Gualtieri & A Facchini. (2000) Osteoblasts and stromal cells isolated from femora in rheumatoid arthritis (RA) and osteoarthritis (OA) patients express IL-11, leukaemia inhibitory factor and oncostatin M. Clinical and Experimental Immunology 119:2, pages 346-353.
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Helene Boeuf, Karine Merienne, Sylvie Jacquot, David Duval, Maria Zeniou, Charlotte Hauss, Beatrice Reinhardt, Yolande Huss-Garcia, Andree Dierich, David A. Frank, Andre Hanauer & Claude Kedinger. (2001) The Ribosomal S6 Kinases, cAMP-responsive Element-binding, and STAT3 Proteins Are Regulated by Different Leukemia Inhibitory Factor Signaling Pathways in Mouse Embryonic Stem Cells. Journal of Biological Chemistry 276:49, pages 46204-46211.
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Lucile Capuron, Alain Ravaud, Norbert Gualde, Eugene Bosmans, Robert Dantzer, Michael Maes & Pierre J Neveu. (2001) Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy. Psychoneuroendocrinology 26:8, pages 797-808.
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Alice Bader, Astrid Gruss, Alexandra Höllrigl, Haifa Al-Dubai, Georg Weitzer & Yassemie Capetanaki. (2001) Paracrine promotion of cardiomyogenesis in embryoid bodies by LIF modulated endoderm. Differentiation 68:1, pages 31-43.
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Claire Mauduit, Isabelle Goddard, Valérie Besset, Eric Tabone, Catherine Rey, Françoise Gasnier, Françoise DacheuxMohamed Benahmed. (2001) Leukemia Inhibitory Factor Antagonizes Gonadotropin Induced-Testosterone Synthesis in Cultured Porcine Leydig Cells: Sites of Action*. Endocrinology 142:6, pages 2509-2520.
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Frédéric Blanchard, Laurence Duplomb, Yanping Wang, Olivier Robledo, Erin Kinzie, Vincent Pitard, Anne Godard, Yannick Jacques & Heinz Baumann. (2000) Stimulation of Leukemia Inhibitory Factor Receptor Degradation by Extracellular Signal-regulated Kinase. Journal of Biological Chemistry 275:37, pages 28793-28801.
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David Duval, Béatrice Reinhardt, Claude Kedinger & Hélène Boeuf. (2000) Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) ‐dependent embryonic stem cell survival. The FASEB Journal 14:11, pages 1577-1584.
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C. J. Auernhammer & S. Melmed. (2000) Leukemia-Inhibitory Factor—Neuroimmune Modulator of Endocrine Function*. Endocrine Reviews 21:3, pages 313-345.
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Hiroshi Mitsumoto & Kazufumi Tsuzaka. (1999) Neurotrophic factors and neuro-muscular disease: II. GDNF, other neurotrophic factors, and future directions. Muscle & Nerve 22:8, pages 1000-1021.
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Ami Tran, Kalman Kovacs, Lucia Stefaneanu, George Kontogeorgos, Bernd W. Scheithauer & Shlomo Melmed. (1999) Expression of leukemia inhibitory factor in craniopharyngioma. Endocrine Pathology 10:2, pages 103-108.
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Mark H. Tuszynski. 1999. CNS Regeneration. CNS Regeneration 109 158 .

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