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Renal Failure Volume 33, 2011 - Issue 2
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Laboratory Studies

Norcantharidin Attenuates Tubulointerstitial Fibrosis in Rat Models with Diabetic Nephropathy

Ying Li Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR ChinaCorrespondence[email protected] [email protected]
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Qiong Chen Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China; Division of Nephrology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, PR China
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Fu-You Liu Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
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You-Ming Peng Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
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Tao Hou Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
,
Shao-Bin Duan Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
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Jun Li Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
,
Jun-Hui Luo Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
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Lin Sun Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
&
Guang-Hui Ling Division of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, PR China; Key Laboratory of Nephrology and Blood Purification in Hunan, Changsha, PR China
 show all
Pages 233-241 | Received 24 Oct 2010, Accepted 06 Jan 2011, Published online: 18 Feb 2011

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Kun Ye, Qiaoyu Wei, Zhifeng Gong, Yunfeng Huang, Hong Liu, Ying Li & Xiaomei Peng. (2017) Effect of norcantharidin on the proliferation, apoptosis, and cell cycle of human mesangial cells. Renal Failure 39:1, pages 458-464.
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Articles from other publishers (14)

Eman H. Yousef, Nada F. Abo El-Magd & Amal M. El Gayar. (2023) Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway. Translational Research 260, pages 69-82.
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Shashipavan Chillappagari, Julian Schwarz, Vidyasagar Kesireddy, Jessica Knoell, Martina Korfei, Konrad Hoetzenecker, M. Lienhard Schmitz, Christian Behl, Saverio Bellusci, Andreas Guenther & Poornima Mahavadi. (2022) Therapeutic induction of Bcl2‐associated athanogene 3‐mediated autophagy in idiopathic pulmonary fibrosis. Clinical and Translational Medicine 12:7.
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Shuaishuai Huang, Gulimire Tuergong, Hangjie Zhu, Xue Wang, Guobin Weng & Yu Ren. (2021) Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells . Acta Pharmaceutica 71:2, pages 267-278.
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Han‐wen Luo, Dan‐dan Yin, Zheng Xiao, Lu Wen, Ying‐jun Liao, Cheng‐yuan Tang, Dong Zeng, Heng‐ting Xiao & Ying Li. (2020) Anti‐renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac‐mediated C‐terminal phosphorylation of Smad3. Chemical Biology & Drug Design 97:2, pages 293-304.
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Dong Zeng, Zheng Xiao, Qianqian Xu, Hanwen Luo, Lu Wen, Chengyuan Tang, Yi Shan, Jiao Tian, Ju Wei & Ying Li. (2020) Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation. Life Sciences 260, pages 118488.
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Chan Liu, Hui Zhuo, Mu‐Yao Ye, Gu‐Xiang Huang, Min Fan & Xian‐Zhe Huang. (2020) LncRNA MALAT1 promoted high glucose‐induced pyroptosis of renal tubular epithelial cell by sponging miR ‐30c targeting for NLRP3 . The Kaohsiung Journal of Medical Sciences 36:9, pages 682-691.
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Zheng Xiao, Lu Wen, Dong Zeng, Dandan Yin, Xun Zhou, Chengyuan Tang & Ying Li. (2020) Protein Phosphatase 2A Inhibiting β-Catenin Phosphorylation Contributes Critically to the Anti-renal Interstitial Fibrotic Effect of Norcantharidin. Inflammation 43:3, pages 878-891.
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Hengting Xiao, Yingjun Liao, Chengyuan Tang, Zheng Xiao, Hanwen Luo, Jun Li, Hong Liu, Lin Sun, Dong Zeng & Ying Li. (2019) RNA‐Seq analysis of potential lncRNAs and genes for the anti‐renal fibrotic effect of norcantharidin. Journal of Cellular Biochemistry 120:10, pages 17354-17367.
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Dan‑Dan Yin, Jun‑Hui Luo, Zhu‑Ye Zhao, Ying‑Jun Liao & Ying Li. (2018) Tranilast prevents renal interstitial fibrosis by blocking mast cell infiltration in a rat model of diabetic kidney disease. Molecular Medicine Reports.
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Chunbo Zou, Rujuan Xie, Yushi Bao, Xiaogang Liu, Manshu Sui, Suhong M, Shuang Li & Huiqing Yin. (2013) Iron chelator alleviates tubulointerstitial fibrosis in diabetic nephropathy rats by inhibiting the expression of tenascinC and other correlation factors. Endocrine 44:3, pages 666-674.
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Chen-Hsi Hsieh, K. S. Clifford Chao, Hui-Fen Liao & Yu-Jen Chen. (2013) Norcantharidin, Derivative of Cantharidin, for Cancer Stem Cells. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-11.
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Michaele B. Manigrasso, R. Taylor Sawyer, Zachary M. HutchensJr.Jr., Elizabeth R. Flynn & Christine Maric-Bilkan. (2012) Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats. American Journal of Physiology-Renal Physiology 302:9, pages F1203-F1209.
Crossref
Ying Li, Yan Ge, Fu You Liu, You Ming Peng, Lin Sun, Jun Li, Qiong Chen, Yan Sun & Kun Ye. (2011) Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis. Molecular and Cellular Biochemistry 361:1-2, pages 79-83.
Crossref
Ying Li, Qiong Chen, Fu-You Liu, You-Ming Peng, Shuai Wang, Ji Li, Jun Li, Shao-Bin Duan, Lin Sun, Guang-Hui Ling & Jun-Hui Luo. (2011) Norcantharidin inhibits the expression of extracellular matrix and TGF-β1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway. Laboratory Investigation 91:12, pages 1706-1716.
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