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Renal Failure Volume 34, 2012 - Issue 10
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Laboratory Study

Antifibrotic Effects of Pirfenidone in Rat Proximal Tubular Epithelial Cells

Koji TakakuraDrug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan
,
Atsuo TaharaDrug Discovery Research, Astellas Pharma Inc., Ibaraki, JapanCorrespondence[email protected]
,
Masanao SanagiDrug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan
,
Hiroyuki ItohDrug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan
&
Yuichi TomuraDrug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan
Pages 1309-1316 | Received 14 Jun 2012, Accepted 24 Jul 2012, Published online: 24 Sep 2012

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Wen Li, Yue Lu, Yan Lou, Shiyue Zhao, Wenpeng Cui, Yangwei Wang, Manyu Luo, Jing Sun & Lining Miao. (2019) FFNT25 ameliorates unilateral ureteral obstruction-induced renal fibrosis. Renal Failure 41:1, pages 419-426.
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Yoshinobu Saito, Arata Azuma, Kuniko Matsuda, Koichiro Kamio, Shinji Abe & Akihiko Gemma. (2016) Pirfenidone exerts a suppressive effect on CCL18 expression in U937-derived macrophages partly by inhibiting STAT6 phosphorylation. Immunopharmacology and Immunotoxicology 38:6, pages 464-471.
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Ren Qi, Wen Li & Shengyou Yu. (2014) FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways. Renal Failure 36:4, pages 589-592.
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Articles from other publishers (6)

Bruno Aristides dos Santos Bronel, Ana Carolina Anauate, Edgar Maquigussa, Mirian Aparecida Boim & Antônio da Silva Novaes. (2022) Determination of reference genes as a quantitative standard for gene expression analysis in mouse mesangial cells stimulated with TGF-β. Scientific Reports 12:1.
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Yuqing Zhang, De Jin, Xiaomin Kang, Rongrong Zhou, Yuting Sun, Fengmei Lian & Xiaolin Tong. (2021) Signaling Pathways Involved in Diabetic Renal Fibrosis. Frontiers in Cell and Developmental Biology 9.
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Emilia Bigaeva, Nataly Puerta Cavanzo, Elisabeth G. D. Stribos, Amos J. de Jong, Carin Biel, Henricus A. M. Mutsaers, Michael S. Jensen, Rikke Nørregaard, Anna M. Leliveld, Igle J. de Jong, Jan-Luuk Hillebrands, Harry van Goor, Miriam Boersema, Ruud A. Bank & Peter Olinga. (2020) Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis. Pharmaceutics 12:5, pages 459.
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Chang Li, Veronika Rezov, Emmi Joensuu, Ville Vartiainen, Mikko Rönty, Miao Yin, Marjukka Myllärniemi & Katri Koli. (2018) Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo. Scientific Reports 8:1.
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Zhenzhen Li, Xianghua Liu, Baoying Wang, Yali Nie, Jianguo Wen, Qingwei Wang & Chaohui Gu. (2017) Pirfenidone suppresses MAPK signalling pathway to reverse epithelial‐mesenchymal transition and renal fibrosis. Nephrology 22:8, pages 589-597.
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Koji Takakura, Kazuhiko Mizukami, Hikaru Mitori, Takahisa Noto & Yuichi Tomura. (2014) Antiproteinuric effect of pirfenidone in a rat model of anti-glomerular basement membrane glomerulonephritis. European Journal of Pharmacology 737, pages 106-116.
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