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State of the Art Review

Renal Cell Apoptosis and New Treatment Options in Sepsis-Induced Acute Kidney Injury

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Pages 291-294 | Received 23 Aug 2012, Accepted 23 Oct 2012, Published online: 27 Nov 2012

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Crossref
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Crossref
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Ying-Yi LuanNing DongMeng XieXian-Zhong XiaoYong-Ming Yao. (2014) The Significance and Regulatory Mechanisms of Innate Immune Cells in the Development of Sepsis. Journal of Interferon & Cytokine Research 34:1, pages 2-15.
Crossref
Adam Romanovsky, Catherine Morgan & Sean M. Bagshaw. (2013) Pathophysiology and management of septic acute kidney injury. Pediatric Nephrology 29:1, pages 1-12.
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