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Autoimmunity Volume 32, 2000 - Issue 2
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Original Article

Protective Effect of Rolipram in Experimental Autoimmune Neuritis: Protection is Associated with Down-Regulation of IFN-γ and Inflammatory Chemokines as Well as Up-Regulation of IL-4 in Peripheral Nervous System

Nagat Abbasa Div. of Geriatric Medicine, Dept. of Clinical Neuroscience, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
,
Li-Ping Zoua Div. of Geriatric Medicine, Dept. of Clinical Neuroscience, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
,
Sigliti-Henrietta Pelidoua Div. of Geriatric Medicine, Dept. of Clinical Neuroscience, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
,
Bengt Winbladb Dept. of Neurochemistry-Neurotoxicology, Stockholms University, Stockholm, Sweden
&
Zie Jiezhua Div. of Geriatric Medicine, Dept. of Clinical Neuroscience, Karolinska Institute, Huddinge Hospital, Stockholm, SwedenCorrespondence[email protected]
Pages 93-99 | Received 26 Aug 1999, Accepted 20 Feb 2000, Published online: 07 Jul 2009

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Hong-Liang Zhang, Limin Wu, Xiujuan Wu & Jie Zhu. (2014) Can IFN-γ be a therapeutic target in Guillain-Barré syndrome?. Expert Opinion on Therapeutic Targets 18:4, pages 355-363.
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Donald R Staines, Ekua W Brenu & Sonya Marshall-Gradisnik. (2009) Postulated vasoactive neuropeptide immunopathology affecting the blood–brain/blood–spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?. Neuropsychiatric Disease and Treatment 5, pages 81-89.
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Antonio La Cava, Margherita Massa, Alberto Mendivil, Alberto Martini & Salvatore Albani. (2002) Genetic Immunization Maps T Cell (Auto)Immune Responses to Self Antigens Homologous to Exogenous Proteins. Autoimmunity 35:2, pages 105-110.
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Articles from other publishers (20)

David Schafflick, Bernd C. Kieseier, Heinz Wiendl & Gerd Meyer zu Horste. (2017) Novel pathomechanisms in inflammatory neuropathies. Journal of Neuroinflammation 14:1.
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Mohammed A. Afifi, Asif A. Jiman-Fatani, Mohammed W. Al-Rabia & Nabeel H. Al-Hussainy. (2014) Application of a phosphodiesterase-4 (PDE4) inhibitor to abort chronic toxoplasmosis and to mitigate consequential pathological changes. Journal of Microscopy and Ultrastructure 2:2, pages 94-99.
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Izabela Wocławek-Potocka, Paulina Rawińska, Ilona Kowalczyk-Zieba, Dorota Boruszewska, Emilia Sinderewicz, Tomasz Waśniewski & Dariusz Jan Skarzynski. (2014) Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract. Mediators of Inflammation 2014, pages 1-14.
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Hong-Liang Zhang, Xiang-Yu Zheng & Jie Zhu. (2013) Th1/Th2/Th17/Treg cytokines in Guillain–Barré syndrome and experimental autoimmune neuritis. Cytokine & Growth Factor Reviews 24:5, pages 443-453.
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Izabela Woclawek-Potocka, Ilona Kowalczyk-Zieba, Monika Tylingo, Dorota Boruszewska, Emilia Sinderewicz & Dariusz Jan Skarzynski. (2013) Effects of lysophopatidic acid on tumor necrosis factor α and interferon γ action in the bovine corpus luteum. Molecular and Cellular Endocrinology 377:1-2, pages 103-111.
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Sharon Chiang & Eroboghene E. Ubogu. (2013) The role of chemokines in guillain–barré syndrome. Muscle & Nerve 48:3, pages 320-330.
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L.P. Francesconi, K.M. Ceres?r, R. Mascarenhas, L. Stertz, C.S. Gama & P. Belmonte-de-Abreu. (2011) Increased annexin-V and decreased TNF-alpha serum levels in chronic-medicated patients with schizophrenia. Neuroscience Letters 502:3, pages 143-146.
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Ming-Ou Lu & Jie Zhu. (2010) The role of cytokines in Guillain–Barré syndrome. Journal of Neurology 258:4, pages 533-548.
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Barry G. Arnason. 2010. The Brain and Host Defense. The Brain and Host Defense 269 307 .
Alfred Sholl‐Franco, Ana Gabriela Ledo Santos Da Silva & Juliana Adão‐Novaes. (2009) Interleukin‐4 as a Neuromodulatory Cytokine. Annals of the New York Academy of Sciences 1153:1, pages 65-75.
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Ajaib S. Paintlia, Manjeet K. Paintlia, Inderjit Singh & Avtar K. Singh. (2008) Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis. Experimental Neurology 214:2, pages 168-180.
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Gerd Meyer Zu Hörste, Wei Hu, Hans‐Peter Hartung, Helmar C. Lehmann & Bernd C. Kieseier. (2007) The immunocompetence of Schwann cells. Muscle & Nerve 37:1, pages 3-13.
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Gerd Meyer zu Hörste, Hans-Peter Hartung & Bernd C Kieseier. (2007) From bench to bedside—experimental rationale for immune-specific therapies in the inflamed peripheral nerve. Nature Clinical Practice Neurology 3:4, pages 198-211.
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Donald R. Staines. (2006) Phosphodiesterase inhibitors may be indicated in the treatment of postulated vasoactive neuropeptide autoimmune fatigue-related disorders. Medical Hypotheses 66:1, pages 203-204.
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Antonio J. Sánchez, Carmen Puerta, Sara Ballester, Paz González, Angel Arriaga & Antonio Garcı´a-Merino. (2005) Rolipram impairs NF-κB activity and MMP-9 expression in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 168:1-2, pages 13-20.
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K. Yamaki, A. H. M. K. Alam, Md. A. Hossain, S. Taneda, R. Yanagisawa, H. Takano & S. Yoshino. (2005) Effect of Rolipram, a Phosphodiesterase IV Inhibitor, on Allergic Footpad Swelling using Various Adjuvants in Mice. Scandinavian Journal of Immunology 62:4, pages 378-384.
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Ana Castro, Maria Jose Jerez, Carmen Gil & Ana Martinez. (2004) Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors. Medicinal Research Reviews 25:2, pages 229-244.
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Ching-Shwun Lin, Guiting Lin, Zhong Wang, Suzan A Maddah & Tom F Lue. (2002) Upregulation of monocyte chemoattractant protein 1 and effects of transforming growth factor-β 1 in Peyronie's disease. Biochemical and Biophysical Research Communications 295:4, pages 1014-1019.
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Douglas L. Feinstein, Elena Galea, Vitaliy Gavrilyuk, Celia F. Brosnan, Caroline C. Whitacre, Lucia Dumitrescu‐Ozimek, Gary E. Landreth, Harrihar A. Pershadsingh, Guy Weinberg & Michael T. Heneka. (2002) Peroxisome proliferator‐activated receptor‐γ agonists prevent experimental autoimmune encephalomyelitis. Annals of Neurology 51:6, pages 694-702.
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Jie Zhu, Eilhard Mix & Bengt Winblad. (2006) The Antidepressant and Antiinflammatory Effects of Rolipram in the Central Nervous System. CNS Drug Reviews 7:4, pages 387-398.
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