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Autoimmunity Volume 43, 2010 - Issue 4
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Research Article

Discrete changes in circulating regulatory T cells during infliximab treatment of Crohn's disease

Christian Lodberg Hvas Gastro-Immuno Research Laboratory (GIRL), Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000 Aarhus C, DenmarkCorrespondence[email protected]
,
Jens Kelsen Gastro-Immuno Research Laboratory (GIRL), Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark
,
Jørgen Agnholt Gastro-Immuno Research Laboratory (GIRL), Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark
,
Anders Dige Gastro-Immuno Research Laboratory (GIRL), Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark
,
Lisbet Ambrosius Christensen Gastro-Immuno Research Laboratory (GIRL), Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark
&
Jens Frederik Dahlerup Gastro-Immuno Research Laboratory (GIRL), Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark
Pages 325-333 | Received 29 Sep 2009, Accepted 13 Nov 2009, Published online: 19 Mar 2010

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Christian L. Hvas, Mia Bendix, Anders Dige, Jens F. Dahlerup & Jørgen Agnholt. (2018) Current, experimental, and future treatments in inflammatory bowel disease: a clinical review. Immunopharmacology and Immunotoxicology 40:6, pages 446-460.
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Anders Dige, Christian Lodberg Hvas, Bent Deleuran, Jens Kelsen, Mia Bendix-Struve, Jens Frederik Dahlerup & Jørgen Agnholt. (2011) Adalimumab treatment in Crohn's disease does not induce early changes in regulatory T cells. Scandinavian Journal of Gastroenterology 46:10, pages 1206-1214.
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Giovanni C Actis, Floriano Rosina & Ian R Mackay. (2011) Inflammatory bowel disease: beyond the boundaries of the bowel. Expert Review of Gastroenterology & Hepatology 5:3, pages 401-410.
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Articles from other publishers (14)

Benoit L. Salomon. (2021) Insights into the biology and therapeutic implications of TNF and regulatory T cells. Nature Reviews Rheumatology 17:8, pages 487-504.
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Kyle Gettler, Mamta Giri, Ephraim Kenigsberg, Jerome Martin, Ling-Shiang Chuang, Nai-Yun Hsu, Lee A. Denson, Jeffrey S. Hyams, Anne Griffiths, Joshua D. Noe, Wallace V. Crandall, David R. Mack, Richard Kellermayer, Clara Abraham, Gabriel Hoffman, Subra Kugathasan & Judy H. Cho. (2019) Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets. Genes & Immunity 20:7, pages 577-588.
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Davide Ribaldone, Rinaldo Pellicano & Giovanni Actis. (2018) Pathogenesis of Inflammatory Bowel Disease: Basic Science in the Light of Real-World Epidemiology. Gastrointestinal Disorders 1:1, pages 129-146.
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Anna Carrasco, Fernando Fernández-Bañares, Elisabet Pedrosa, Antonio Salas, Carme Loras, Mercè Rosinach, Montserrat Aceituno, Xavier Andújar, Montserrat Forné, Yamile Zabana & Maria Esteve. (2016) Regional Specialisation of T Cell Subsets and Apoptosis in the Human Gut Mucosa: Differences Between Ileum and Colon in Healthy Intestine and Inflammatory Bowel Diseases. Journal of Crohn's and Colitis 10:9, pages 1042-1054.
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Giovanni Clemente Actis. (2016) The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology. Annals of Colorectal Research 4:1.
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A. Dige, S. Støy, K. L. Thomsen, C. L. Hvas, J. Agnholt, J. F. Dahlerup, H. J. Møller & H. Grønbaek. (2014) Soluble CD163, a Specific Macrophage Activation Marker, is Decreased by Anti-TNF- α Antibody Treatment in Active Inflammatory Bowel Disease . Scandinavian Journal of Immunology 80:6, pages 417-423.
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Maria K Magnusson, Rahil Dahlén, Hans Strid, Stefan Isaksson, Magnus Simrén, Anders Lasson, Antal Bajor, Kjell‐Arne Ung & Lena Öhman. (2013) CD25 and TNF receptor II reflect early primary response to infliximab therapy in patients with ulcerative colitis. United European Gastroenterology Journal 1:6, pages 467-476.
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David J. Gibson, Elizabeth J. Ryan & Glen A. Doherty. (2013) Keeping the Bowel Regular. Inflammatory Bowel Diseases 19:12, pages 2716-2724.
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R. Dahlén, H. Strid, A. Lundgren, S. Isaksson, S. Raghavan, M. K. Magnusson, M. Simrén, H. Sjövall & L. Öhman. (2013) Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cells in vitro from Patients with Clinically Active Ulcerative Colitis . Scandinavian Journal of Immunology 78:3, pages 275-284.
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Jens Kelsen, Lars Erik Bartels, Anders Dige, Christian Lodberg Hvas, Petra Frings-Meuthen, Gisela Boehme, Marianne Kragh Thomsen, Morten Fenger-Grøn & Jens Frederik Dahlerup. (2012) 21 Days head-down bed rest induces weakening of cell-mediated immunity – Some spaceflight findings confirmed in a ground-based analog. Cytokine 59:2, pages 403-409.
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J Grundström, L Linton, S Thunberg, H Forsslund, I Janczewska, R Befrits, M van Hage, G Gafvelin & M Eberhardson. (2012) Altered immunoregulatory profile during anti-tumour necrosis factor treatment of patients with inflammatory bowel disease. Clinical and Experimental Immunology 169:2, pages 137-147.
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Jens Kelsen, Anders Dige, Heinrich Schwindt, Francesco D'Amore, Finn S. Pedersen, Jørgen Agnholt, Lisbet A. Christensen, Jens F. Dahlerup & Christian L. Hvas. (2011) Infliximab Induces Clonal Expansion of γδ-T Cells in Crohn's Disease: A Predictor of Lymphoma Risk?. PLoS ONE 6:3, pages e17890.
Crossref
Jane Hoyt Buckner. (2010) Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases. Nature Reviews Immunology 10:12, pages 849-859.
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Thomas W. Lee & Richard N. Fedorak. (2010) Tumor Necrosis Factor-α Monoclonal Antibodies in the Treatment of Inflammatory Bowel Disease: Clinical Practice Pharmacology. Gastroenterology Clinics of North America 39:3, pages 543-557.
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