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Autoimmunity Volume 46, 2013 - Issue 1
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Articles

Lupus autoimmunity altered by cellular methylation metabolism

Mei-Ling YangSection of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
,
Alaric J.P. GeeSection of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
,
Renelle J. GeeSection of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
,
Cecilia I. Zurita-LopezDepartment of Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA
,
Shilpi KhareDepartment of Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA
,
Steven G. ClarkeDepartment of Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA
&
Mark J. MamulaSection of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USACorrespondence[email protected]
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Pages 21-31 | Received 22 Jun 2012, Accepted 15 Sep 2012, Published online: 01 Nov 2012

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Heng Li, Huimin Lu, Wei Tang & Jianping Zuo. (2017) Targeting methionine cycle as a potential therapeutic strategy for immune disorders. Expert Opinion on Therapeutic Targets 21:9, pages 861-877.
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Frederik C. Henrich, Katrin Singer, Kerstin Poller, Luise Bernhardt, Carolin D. Strobl, Katharina Limm, Axel P. Ritter, Eva Gottfried, Simon Völkl, Benedikt Jacobs, Katrin Peter, Dimitrios Mougiakakos, Katja Dettmer, Peter J. Oefner, Anja-Katrin Bosserhoff, Marina P. Kreutz, Michael Aigner & Andreas Mackensen. (2016) Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells. OncoImmunology 5:8.
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Hester A. Doyle, Mei-Ling Yang, Maurice T. Raycroft, Renelle J. Gee & Mark J. Mamula. (2014) Autoantigens: Novel forms and presentation to the immune system. Autoimmunity 47:4, pages 220-233.
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Aijing Liu & Antonio La Cava. (2014) Epigenetic dysregulation in systemic lupus erythematosus. Autoimmunity 47:4, pages 215-219.
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Articles from other publishers (34)

Yuxian Wu, Mengpei Zhao, Na Gong, Feng Zhang, Wansheng Chen & Yaoyang Liu. (2023) Immunometabolomics provides a new perspective for studying systemic lupus erythematosus. International Immunopharmacology 118, pages 109946.
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Fang Wang, Hai-bing Miao, Zhi-hua Pei & Zhen Chen. (2022) Serological, fragmentomic, and epigenetic characteristics of cell-free DNA in patients with lupus nephritis. Frontiers in Immunology 13.
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Weijing Dai, Jianguo Zhang, Siqi Li, Fajian He, Qiao Liu, Jun Gong, Zetian Yang, Yan Gong, Fang Tang, Zhihao Wang & Conghua Xie. (2022) Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy. Frontiers in Immunology 13.
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Ying Zhang, Zhaojun Li, Haijie Wu, Jing Wang & Sen Zhang. (2022) Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway. Journal of Ethnopharmacology 288, pages 115004.
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Valentina Pucino. 2022. Translational Autoimmunity. Translational Autoimmunity 31 45 .
Fan Yang, Jin Lin & Weiqian Chen. (2021) Post-translational modifications in T cells in systemic erythematosus lupus. Rheumatology 60:6, pages 2502-2516.
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Mei-Ling Yang, Fernanda M. C. Sodré, Mark J. Mamula & Lut Overbergh. (2021) Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pathology. Frontiers in Immunology 12.
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Xiao-Jun Chen, Hong Zhang, Fei Yang, Yu Liu & Guochun Chen. (2021) DNA Methylation Sustains “Inflamed” Memory of Peripheral Immune Cells Aggravating Kidney Inflammatory Response in Chronic Kidney Disease. Frontiers in Physiology 12.
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Jon D. Piganelli, Mark J. Mamula & Eddie A. James. (2021) The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes. Frontiers in Endocrinology 11.
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Ali Mehdi & Shafaat A. Rabbani. (2021) Role of Methylation in Pro- and Anti-Cancer Immunity. Cancers 13:3, pages 545.
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Li Chen, Zemin Lin, Yuting Liu, Shiqi Cao, Yueteng Huang, Xiaoqian Yang, Fenghua Zhu, Wei Tang, Shijun He & Jianping Zuo. (2021) DZ2002 alleviates psoriasis-like skin lesions via differentially regulating methylation of GATA3 and LCN2 promoters. International Immunopharmacology 91, pages 107334.
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Mihoko Shimada, Taku Miyagawa, Tohru Kodama, Hiromi Toyoda, Katsushi Tokunaga & Makoto Honda. (2020) Metabolome analysis using cerebrospinal fluid from narcolepsy type 1 patients. Sleep 43:11.
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Shouvonik Sengupta, Austin Kennemer, Kristin Patrick, Philip Tsichlis & Mireia Guerau-de-Arellano. (2020) Protein Arginine Methyltransferase 5 in T Lymphocyte Biology. Trends in Immunology 41:10, pages 918-931.
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Lindsay M. Webb, Shouvonik Sengupta, Claudia Edell, Zayda L. Piedra-Quintero, Stephanie A. Amici, Janiret Narvaez Miranda, Makenzie Bevins, Austin Kennemer, Georgios Laliotis, Philip N. Tsichlis & Mireia Guerau-de-Arellano. (2020) Protein arginine methyltransferase 5 promotes cholesterol biosynthesis–mediated Th17 responses and autoimmunity. Journal of Clinical Investigation 130:4, pages 1683-1698.
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Carolin Dorothea Strobl, Stefanie Schaffer, Tabea Haug, Simon Völkl, Katrin Peter, Katrin Singer, Martin Böttcher, Dimitrios Mougiakakos, Andreas Mackensen & Michael Aigner. (2020) Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA. Molecular Cancer Therapeutics 19:2, pages 409-419.
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Chen-xing Zhang, Hui-yu Wang, Lei Yin, You-ying Mao & Wei Zhou. (2020) Immunometabolism in the pathogenesis of systemic lupus erythematosus. Journal of Translational Autoimmunity 3, pages 100046.
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Qiancheng Deng, Yangyang Luo, Christopher Chang, Haijing Wu, Yan Ding & Rong Xiao. (2019) The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review. Frontiers in Immunology 10.
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Jian Ji, Yibin Xu, Mingzhu Zheng, Chenglong Luo, Huangtao Lei, Hao Qu & Dingming Shu. (2019) Methionine Attenuates Lipopolysaccharide-Induced Inflammatory Responses via DNA Methylation in Macrophages. ACS Omega 4:1, pages 2331-2336.
Crossref
Zijun Wang, Hai Long, Christopher Chang, Ming Zhao & Qianjin Lu. (2018) Crosstalk between metabolism and epigenetic modifications in autoimmune diseases: a comprehensive overview. Cellular and Molecular Life Sciences 75:18, pages 3353-3369.
Crossref
Nick Huang & Andras Perl. (2018) Metabolism as a Target for Modulation in Autoimmune Diseases. Trends in Immunology 39:7, pages 562-576.
Crossref
Ze-Min Lin, Meng Ma, Heng Li, Qing Qi, Yu-Ting Liu, Yu-Xi Yan, Yun-Fu Shen, Xiao-Qian Yang, Feng-Hua Zhu, Shi-Jun He, Wei Tang & Jian-Ping Zuo. (2018) Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17. Pharmacological Research 129, pages 443-452.
Crossref
Peter A. Morawski & Silvia Bolland. (2017) Expanding the B Cell-Centric View of Systemic Lupus Erythematosus. Trends in Immunology 38:5, pages 373-382.
Crossref
Lindsay M. Webb, Stephanie A. Amici, Kyle A. Jablonski, Himanshu Savardekar, Amanda R. Panfil, Linsen Li, Wei Zhou, Kevin Peine, Vrajesh Karkhanis, Eric M. Bachelder, Kristy M. Ainslie, Patrick L. Green, Chenglong Li, Robert A. Baiocchi & Mireia Guerau-de-Arellano. (2017) PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. The Journal of Immunology 198:4, pages 1439-1451.
Crossref
Zhenggui Du, Yongjie Zhou, Xufeng Lu, Lei Li, Changli Lu, Li Li, Bo Li, Hong Bu, Jiayin Yang & Yujun Shi. (2015) Octreotide prevents liver failure through upregulating 5′‐methylthioadenosine in extended hepatectomized rats. Liver International 36:2, pages 212-222.
Crossref
Michel Neidhart. 2016. DNA Methylation and Complex Human Disease. DNA Methylation and Complex Human Disease 405 418 .
Louise A. Rollins-Smith, J. Scott Fites, Laura K. Reinert, Andrea R. Shiakolas, Thomas P. Umile & Kevin P. C. Minbiole. (2015) Immunomodulatory Metabolites Released by the Frog-Killing Fungus Batrachochytrium dendrobatidis. Infection and Immunity 83:12, pages 4565-4570.
Crossref
Rebecca W. Y. ChanPeiyong JiangXianlu PengLai-Shan Tam, Gary J. W. LiaoEdmund K. M. Li, Priscilla C. H. Wong, Hao SunK. C. Allen Chan, Rossa W. K. ChiuY. M. Dennis Lo. (2014) Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing. Proceedings of the National Academy of Sciences 111:49.
Crossref
Carlo Selmi. (2014) Autoimmunity in 2013. Clinical Reviews in Allergy & Immunology 47:1, pages 100-109.
Crossref
C-G Miao, J-T Yang, Y-Y Yang, C-L Du, C Huang, Y Huang, L Zhang, X-W Lv, Y Jin & J Li. (2014) Critical role of DNA methylation in the pathogenesis of systemic lupus erythematosus: new advances and future challenges. Lupus 23:8, pages 730-742.
Crossref
Steven G Gray. (2014) Epigenetic-based immune intervention for rheumatic diseases. Epigenomics 6:2, pages 253-271.
Crossref
Shi-jun He, Ze-min Lin, Yan-wei Wu, Bing-xin Bai, Xiao-qian Yang, Pei-lan He, Feng-hua Zhu, Wei Tang & Jian-ping Zuo. (2013) Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response. Acta Pharmacologica Sinica 35:2, pages 219-229.
Crossref
Kathleen M. Gilbert. 2014. Trichloroethylene: Toxicity and Health Risks. Trichloroethylene: Toxicity and Health Risks 15 35 .
Dan Knights, Kara G Lassen & Ramnik J Xavier. (2013) Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome. Gut 62:10, pages 1505-1510.
Crossref

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