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Autoimmunity Volume 48, 2015 - Issue 5
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Original Article

Reactivation of persistent Epstein–Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface

Keiko NagataDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan, Correspondence[email protected]
,
Yuji NakayamaDivision of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Yonago, Tottori, Japan,
,
Katsumi HigakiDivision of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Yonago, Tottori, Japan,
,
Marika OchiDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan,
,
Kyosuke KanaiDepartment of Microbiology, Faculty of Medicine, Kinki University, Osakasayama, Osaka, Japan, and
,
Michiko MatsushitaDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan,
,
Satoshi KuwamotoDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan,
,
Masako KatoDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan,
,
Ichiro MurakamiDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan,
,
Takeshi IwasakiDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan,
,
Eiji NanbaDivision of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Yonago, Tottori, Japan,
,
Hiroshi KimuraDepartment of Virology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan
&
Kazuhiko HayashiDivision of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan,
show all
Pages 328-335 | Received 21 Jul 2014, Accepted 11 Feb 2015, Published online: 11 Mar 2015

Citations (20)

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Shizuka Kirino, Hisae Nakatani, Aoi Honma, Asami Shinbo, Keiko Onda, Mari Okada, Masako Imai, Natsuko Suzuki, Akihiro Oshiba & Masayuki Nagasawa. (2020) An eight-year-old girl with autoimmune polyglandular syndrome type3A that developed during the course of primary Epstein–Barr virus (EBV) infection: clinical implication of EBV in autoimmune thyroid disease. Immunological Medicine 43:1, pages 57-60.
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Articles from other publishers (19)

Hernando Vargas-Uricoechea. (2023) Molecular Mechanisms in Autoimmune Thyroid Disease. Cells 12:6, pages 918.
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Keiko Nagata, Kazuhiko Hayashi, Keisuke Kumata, Yukio Satoh, Mitsuhiko Osaki, Yuji Nakayama, Satoshi Kuwamoto, Yoshinori Ichihara, Tsuyoshi Okura, Kazuhiko Matsuzawa, Junichiro Miake, Shuji Fukata & Takeshi Imamura. (2023) Epstein-Barr virus reactivation in peripheral B lymphocytes induces IgM-type thyrotropin receptor autoantibody production in patients with Graves’ disease. Endocrine Journal 70:6, pages 619-627.
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Silvia Martina Ferrari, Fabrizio Guarneri, Poupak Fallahi, Alessandro Antonelli & Salvatore Benvenga. 2022. Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases. Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases 333 364 .
Mosin S. Khan, Suhail S. Lone, Sunia Faiz, Iqra Farooq & Sabhiya Majid. 2021. Graves' Disease. Graves' Disease.
Michał Olejarz, Ewelina Szczepanek-Parulska, Daniela Dadej, Nadia Sawicka-Gutaj, Remigiusz Domin & Marek Ruchała. (2021) IgG4 as a Biomarker in Graves’ Orbitopathy. Mediators of Inflammation 2021, pages 1-11.
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Yosuke Nagasawa, Masami Takei, Mitsuhiro Iwata, Yasuko Nagatsuka, Hiroshi Tsuzuki, Kenichi Imai, Ken-Ichi Imadome, Shigeyoshi Fujiwara & Noboru Kitamura. (2021) Human osteoclastogenesis in Epstein-Barr virus-induced erosive arthritis in humanized NOD/Shi-scid/IL-2Rγnull mice. PLOS ONE 16:4, pages e0249340.
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Juliana Muñoz-Ortiz, Maria Camila Sierra-Cote, Estefanía Zapata-Bravo, Laura Valenzuela-Vallejo, Maria Alejandra Marin-Noriega, Pilar Uribe-Reina, Juan Pablo Terreros-Dorado, Marcela Gómez-Suarez, Karla Arteaga-Rivera & Alejandra de-la-Torre. (2020) Prevalence of hyperthyroidism, hypothyroidism, and euthyroidism in thyroid eye disease: a systematic review of the literature. Systematic Reviews 9:1.
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Keiko Nagata & Kazuhiko Hayashi. (2020) Epstein–Barr Virus Reactivation-Induced Immunoglobulin Production: Significance on Autoimmunity. Microorganisms 8:12, pages 1875.
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Alessandro Antonelli, Silvia Martina Ferrari, Francesca Ragusa, Giusy Elia, Sabrina Rosaria Paparo, Ilaria Ruffilli, Armando Patrizio, Claudia Giusti, Debora Gonnella, Alfonso Cristaudo, Rudy Foddis, Yehuda Shoenfeld & Poupak Fallahi. (2020) Graves’ disease: Epidemiology, genetic and environmental risk factors and viruses. Best Practice & Research Clinical Endocrinology & Metabolism 34:1, pages 101387.
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Naohiro TamotoKeiko NagataSayuri HaraYuji NakayamaSatoshi KuwamotoMichiko MatsushitaMasako KatoKazuhiko Hayashi. (2019) Subclinical Epstein-Barr Virus Primary Infection and Lytic Reactivation Induce Thyrotropin Receptor Autoantibodies. Viral Immunology 32:9, pages 362-369.
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David López-Valencia, Ángela Medina-Ortega, Diego Fernando Hoyos-Samboní, Jhan Sebastián Saavedra-Torres & Carolina Salguero. (2019) Epstein-Barr virus infection as a predisposing factor for multiple sclerosis. An update from molecular biology, immunology and epidemiology. Revista de la Facultad de Medicina 67:3, pages 305-313.
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Aleksandra Pyzik, Ewelina Grywalska, Beata Matyjaszek-Matuszek, Jarosław Ludian, Ewa Kiszczak-Bochyńska, Agata Smoleń, Jacek Roliński & Dawid Pyzik. (2019) Does the Epstein–Barr Virus Play a Role in the Pathogenesis of Graves’ Disease?. International Journal of Molecular Sciences 20:13, pages 3145.
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Sayuri Hara, Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato & Kazuhiko Hayashi. (2019) High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls. Yonago Acta Medica 62:2, pages 240-243.
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Keiko NagataSayuri HaraYuji NakayamaKatsumi HigakiHirotsugu SugiharaSatoshi KuwamotoMichiko MatsushitaMasako KatoShunsuke TanioKiyosuke IshiguroKazuhiko Hayashi. (2018) Epstein–Barr Virus Lytic Reactivation Induces IgG4 Production by Host B Lymphocytes in Graves' Disease Patients and Controls: A Subset of Graves' Disease Is an IgG4-Related Disease-Like Condition. Viral Immunology 31:8, pages 540-547.
Crossref
Sayuri HaraKeiko NagataKeisuke KumataMichiko MatsushitaSatoshi KuwamotoMasako KatoKazuhiko Hayashi. (2018) Estradiol Affects Epstein–Barr Virus Reactivation-Induced Thyrotropin Receptor Antibody and Immunoglobulin Production in Graves’ Disease Patients and Healthy Controls. Viral Immunology 31:7, pages 486-491.
Crossref
Keiko NagataKeisuke KumataYuji NakayamaYukio SatohHirotsugu SugiharaSayuri HaraMichiko MatsushitaSatoshi KuwamotoMasako KatoIchiro MurakamiKazuhiko Hayashi. (2017) Epstein–Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease. Viral Immunology 30:3, pages 240-249.
Crossref
Terry J. Smith & Laszlo Hegedüs. (2016) Graves’ Disease. New England Journal of Medicine 375:16, pages 1552-1565.
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Keisuke KumataKeiko NagataMichiko MatsushitaSatoshi KuwamotoMasako KatoIchiro MurakamiShuji FukataKazuhiko Hayashi. (2016) Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein–Barr Virus Reactivation. Viral Immunology 29:8, pages 459-463.
Crossref
Keiko Nagata, Keisuke Okuno, Marika Ochi, Keisuke Kumata, Hitoshi Sano, Naohiro Yoneda, Jun-ichi Ueyama, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Ichiro Murakami, Susumu Kanzaki & Kazuhiko Hayashi. (2015) Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child. SpringerPlus 4:1.
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