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Autoimmunity Volume 1, 1988 - Issue 3
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Original Article

Inherited Susceptibility to Insulin-Dependent Diabetes is Associated with HLA-DR1, while DR5 is Protective

Noel Maclaren Departments of Pathology and Pediatrics, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
William Riley Departments of Pathology and Pediatrics, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
Nicos Skordis Departments of Pathology and Pediatrics, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
Mark Atkinson Departments of Pathology and Pediatrics, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
Rebecca Spillar Departments of Pathology and Pediatrics, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
Janet Silverstein Departments of Pathology and Pediatrics, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
Ronald Klein Department of Ophthalmology, University of Wisconsin, Wisconsin, USA
,
Constance Vadheim Division of Medical Genetics, Departments of Medicine and Pediatrics, Cedars Sinai Medical Center, Los Angeles, California, 90048, USA
&
Jerome Rotter Division of Medical Genetics, Departments of Medicine and Pediatrics, Cedars Sinai Medical Center, Los Angeles, California, 90048, USA
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Pages 197-205 | Received 23 Sep 1987, Published online: 07 Jul 2009

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J. X. She, M. M. Bui, X. H. Tian, A. Muir, E. K. Wakeland, B. Zorovich, L. P. Zhang, M. C. Liu, G. Thomson & Noel K. Maclaren. (1994) Additive Susceptibility to Insulin-Dependent Diabetes Conferred by Hla-Dqb1 and Insulin Genes. Autoimmunity 18:3, pages 195-203.
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Nadir R. Farid. (1989) Are The Immune Responses to Endocrine Autoantigens Genetically Restricted?. Autoimmunity 3:1, pages 47-55.
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Articles from other publishers (22)

Shao-Chang Wang & Jung-Yu Liao. (2022) Epidemiologic Implication of the Association between Herpes Simplex Virus Infection and the Risk of Type 1 Diabetes Mellitus: A Nationwide Case-Control Study in Taiwan. International Journal of Environmental Research and Public Health 19:13, pages 7832.
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Mary Joyce Gan, Anastasia Albanese-O’Neill & Michael J. Haller. (2012) Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research. Current Problems in Pediatric and Adolescent Health Care 42:10, pages 269-291.
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Desmond Schatz, David Cuthbertson, Mark Atkinson, Michael Clare Salzler, William Winter, Andrew Muir, Janet Silverstein, Roberta Cook, Noel Maclaren, Jin-Xiong She, Carla Greenbaum & Jeffrey Krischer. (2004) Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus - a new surrogate measure of non-progression?. Pediatric Diabetes 5:2, pages 72-79.
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Patricio Giralt Muiña, José Miguel Urra Ardanaz, Concepción Sanabria Pérez, Juan Giralt Muiña, María José Pérez Rodríguez & Pedro Benito López. (2003) Diferencias biológicas en la presentación de la diabetes 1A, en relación con los marcadores genéticos HLA-DQ. Medicina Clínica 120:1, pages 6-9.
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Tien Yin Wong, Karen J Cruickshank, Ronald Klein, Barbara E.K Klein, Scot E Moss, Mari Palta, William J Riley, Noel K Maclaren, Constance M Vadheim & Jerome I Rotter. (2002) HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy1 1The authors have no proprietary interest in any of the products mentioned in this study.. Ophthalmology 109:2, pages 275-281.
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Karen Lin-SuAnjli KukrejaNoel K. MacLaren. (2001) Diabetes Vaccines: A Future to be Realized. Diabetes Technology & Therapeutics 3:3, pages 451-461.
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Gerald T. Nepom. 2000. HLA in Health and Disease. HLA in Health and Disease 231 237 .
William E. Winter. (1999) The use of islet autoantibody markers in the prediction of autoimmune type 1 diabetes. Clinical Immunology Newsletter 19:3, pages 25-39.
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Dorlinda V. House & William E. Winter. (1997) Autoimmune Diabetes. Clinics in Laboratory Medicine 17:3, pages 499-545.
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John A. Lott. 1997. Clinical Pathology of Pancreatic Disorders. Clinical Pathology of Pancreatic Disorders 1 25 .
W.E. Winter. (2016) Type I Insulin-Dependent Diabetes Mellitus: a Model for Autoimmune Polygenic Disorders. Advances in Dental Research 10:1, pages 81-87.
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Glenn Y. Deng, Noel K. Maclaren, Hong-So Huang, Li-Ping Zhang & Jin-Xiong She. (1996) No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus. Human Immunology 45:2, pages 137-142.
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Andrew Muir & Desmond Schatz. (1995) Prevention of insulin-dependent diabetes—1995. Trends in Endocrinology & Metabolism 6:9-10, pages 312-317.
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Franklin H. Epstein, Mark A. Atkinson & Noel K. Maclaren. (1994) The Pathogenesis of Insulin-Dependent Diabetes Mellitus. New England Journal of Medicine 331:21, pages 1428-1436.
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Rashmi Kaul, Mohan Shenoy & Premkumar Christadoss. (1994) The role of major histocompatibility complex genes in myasthenia gravis and experimental autoimmune myasthenia gravis pathogenesis. Advances in Neuroimmunology 4:4, pages 387-402.
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Henry A. Erlich, Adina Zeidler, Julie Chang, Sylvia Shaw, Leslie J. Raffel, William Klitz, Yolanda Beshkov, Gertrude Costin, Sheila Pressman, Teodorica Bugawan & Jerome I. Rotter. (1993) HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Nature Genetics 3:4, pages 358-364.
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Andrew Muir, Desmond A. Schatz & Noel K. Maclaren. (1992) The Pathogenesis, Prediction, and Prevention of Insulin-Dependent Diabetes Mellitus. Endocrinology and Metabolism Clinics of North America 21:2, pages 199-219.
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XiaoYan Zhang, Xiu-Ming Wang & Tian-Sheng Hu. (1992) Profiling Human Leukocyte Antigens in Vogt-Koyanagi-Harada Syndrome. American Journal of Ophthalmology 113:5, pages 567-572.
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M. Baines & A. Ebringer. (1992) Hla and disease. Molecular Aspects of Medicine 13:4, pages 263-378.
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J. A. Todd. 1990. Human Diabetes. Human Diabetes 17 40 .
Desmond A. Schatz, Harold Kowa, William E. Winter & William J. Riley. (1989) Natural history of incidental hyperglycemia and glycosuria of childhood. The Journal of Pediatrics 115:5, pages 676-680.
Crossref
Janet Silverstein, Noel Maclaren, William Riley, Rebecca Spillar, Doreen Radjenovic & Suzanne Johnson. (1988) Immunosuppression with Azathioprine and Prednisone in Recent-Onset Insulin-Dependent Diabetes Mellitus. New England Journal of Medicine 319:10, pages 599-604.
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