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Original Article

Epitopes on Human Acetylcholine Receptor Defined by Monoclonal Antibodies and Myasthenia Gravis Sera

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Pages 285-297 | Published online: 07 Jul 2009

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J. P. Banga, P. S. Barnett & A. M. McGregor. (1991) Immunological and Molecular Characteristics of the Thyroid Peroxidase Autoantigen. Autoimmunity 8:4, pages 335-343.
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S. J. Tzartos, T. Barkas, M. T. Cung, A. Kordossi, H. Loutrari, M. Marraud, I. Papadouli, C. Sakarellos, D. Sophianos & V. Tsikaris. (1991) The Main Immunogenic Region of the Acetylcholine Receptor. Structure and Role in Myasthenia Gravis. Autoimmunity 8:4, pages 259-270.
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Peggy Lymberi, Markella Zannikou & Aikaterini Hatzioannou. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 342 368 .
Jin GuoSandra M. McLachlanBasil Rapoport. (2006) Antibodies Focused on the Human Autoantibody Immunodominant Region Are Induced by B Lymphocytes that Constitutively Express Thyroid Peroxidase Diverted to the Major Histocompatibility Complex II Pathway. Thyroid 16:4, pages 343-349.
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Samia Ragheb, Mahmoud Mohamed & Robert P. Lisak. (2005) Myasthenia gravis patients, but not healthy subjects, recognize epitopes that are unique to the ?-subunit of the acetylcholine receptor. Journal of Neuroimmunology 159:1-2, pages 137-145.
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J Guo, Y Wang, B Rapoport & S M Mclachlan. (2000) Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)-specific B cells in mice injected with fibroblasts co-expressing TPO and MHC class II. Clinical and Experimental Immunology 119:1, pages 38-46.
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I C LOCKE, B LEAKER & G CAMBRIDGE. (1999) A comparison of the characteristics of circulating anti-myeloperoxidase autoantibodies in vasculitis with those in non-vasculitic conditions. Clinical and Experimental Immunology 115:2, pages 369-376.
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Guang X. Luo, Kimberly Victor, Korey Chong, Patricia McNeeley, David Ramirez, Joddi Preclaro, Matthew D. Linnik & Mary-Ann Campbell. (2001) Identification of a peptide that protects the human acetylcholine receptor against antigenic modulation. Journal of Immunological Methods 251:1-2, pages 177-186.
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Pavel Pichurin, Jin Guo, Xinmin Yan, Basil Rapoport & Sandra M. McLachlan. (2001) Human Monoclonal Autoantibodies to B-Cell Epitopes Outside the Thyroid Peroxidase Autoantibody Immunodominant Region. Thyroid 11:4, pages 301-313.
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Nikolaos Trakas & Socrates J Tzartos. (2001) Conjugation of acetylcholine receptor-protecting Fab fragments with polyethylene glycol results in a prolonged half-life in the circulation and reduced immunogenicity. Journal of Neuroimmunology 120:1-2, pages 42-49.
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Danai Papanastasiou, Konstantinos Poulas, Anna Kokla & Socrates J Tzartos. (2000) Prevention of passively transferred experimental autoimmune myasthenia gravis by Fab fragments of monoclonal antibodies directed against the main immunogenic region of the acetylcholine receptor. Journal of Neuroimmunology 104:2, pages 124-132.
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Sandra M McLachlan & Basil Rapoport. (2000) A powerful role for B cells and autoantibodies in disease. Immunology Today 21:1, pages 57.
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Leslie Jacobson, David Beeson, Socrates Tzartos & Angela Vincent. (1999) Monoclonal antibodies raised against human acetylcholine receptor bind to all five subunits of the fetal isoform. Journal of Neuroimmunology 98:2, pages 112-120.
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Socrates J. Tzartos, Tom Barkas, M. Thong Cung, Avgi Mamalaki, Michel Marraud, Piotr Orlewski, Danai Papanastasiou, Constantinos Sakarellos, Maria Sakarellos‐Daitsiotis, Panayota Tsantili & Vassilios Tsikaris. (2006) Anatomy of the antigenic structure of a large memberane autoantigen, the muscle‐type nicotinic acetylcholine receptor. Immunological Reviews 163:1, pages 89-120.
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Stefan Gattenlöhner, Hans-Konrad Müller-Hermelink & Alexander Marx. (1998) Polymerase Chain Reaction-Based Diagnosis of Rhabdomyosarcomas. Diagnostic Molecular Pathology 7:3, pages 129-134.
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ANGELA VINCENT, LESLIE JACOBSON, PAUL PLESTED, AGATA POLIZZI, TERESA TANG, SIETSKE RIEMERSMA, CLAIRE NEWLAND, SARA GHORAZIAN, JEREMY FARRAR, CAL MACLENAN, NICHOLAS WILLCOX, DAVID BEESON & JOHN NEWSDOM‐DAVIS. (2006) Antibodies Affecting Ion Channel Function in Acquired Neuromyotonia, in Seropositive and Seronegative Myasthenia Gravis, and in Antibody‐mediated Arthrogryposis Multiplex Congenita. Annals of the New York Academy of Sciences 841:1, pages 482-496.
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Jin Guo, Sonia Quaratino, Juan Carlos Jaume, Giuseppe Costante, Marco Londei, Sandra M. McLachlan & Basil Rapoport. (1996) Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fcε receptor by a recombinant human autoantibody Fab converted to IgE. Journal of Immunological Methods 195:1-2, pages 81-92.
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Angela Vincent, Leslie Jacobson & Paul Shillito. (1994) Response to human acetylcholine receptor α138–199: determinant spreading initiates autoimmunity to self-antigen in rabbits. Immunology Letters 39:3, pages 269-275.
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Avgi Mamalaki & Socrates J. Tzartos. (1994) Nicotinic acetylcholine receptor: Structure, function and main immunogenic region. Advances in Neuroimmunology 4:4, pages 339-354.
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Andy Jermy, David Beeson & Angela Vincent. (2005) Pathogenic autoimmunity to affinity‐purified mouse acetylcholine receptor induced without adjuvant in BALB/c mice. European Journal of Immunology 23:4, pages 973-976.
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Yvo M. F. Graus & Marc H. De Baets. (1993) Myasthenia gravis: An autoimmune response against the acetylcholine receptor. Immunologic Research 12:1, pages 78-100.
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Jack D. Griffith & Vincent F. Garry. 1993. Molecular Epidemiology. Molecular Epidemiology 497 515 .
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S. J. Tzartos, M. T. Cung, P. Demange, H. Loutrari, A. Mamalaki, M. Marraud, I. Papadouli, C. Sakarellos & V. Tsikaris. (1991) The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti-MIR antibodies. Molecular Neurobiology 5:1, pages 1-29.
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