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Original Article

High Potential to Tumor Necrosis Factor α (TNF-α) Production of Thyroid Infiltrating T Lymphocytes in Hashimoto's Thyroiditis: A Peculiar Feature of Destructive Thyroid Autoimmunity

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Pages 267-276 | Received 06 Apr 1989, Published online: 07 Jul 2009

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Bong-Seok Kang, Ji-Yeong Han, Sung-Koo Kang, Dong-IL Kim, June-Ki Kim & Cheorl-Ho Kim. (2006) Effect of the Traditional Korean Immunomodulating Formulation, Gamguntang (GGT), on Experimental Thyroiditis Model. Immunopharmacology and Immunotoxicology 28:1, pages 51-66.
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Mario M. D'Elios, Amedeo Amedei, Annalisa Azzurri, Marisa Benagiano, Gianfranco Del Prete, Mathijs P. Bergman, Christina M. Vandenbroucke-Grauls & Ben J. Appelmelk. (2005) Molecular Specificity and Functional Properties of Autoreactive T-Cell Response in Human Gastric Autoimmunity. International Reviews of Immunology 24:1-2, pages 111-122.
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Masayo Yamada, Audrey Wu Li & Jack R. Wall. (2000) Thyroid-Associated Ophthalmopathy: Clinical Features, Pathogenesis, and Management. Critical Reviews in Clinical Laboratory Sciences 37:6, pages 523-549.
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Marco De Carli, Mario M. D'elios, Gianna Zancuoghi, Sergio Romagnani & Gianfranco Del Prete. (1994) Review Human Th1 and Th2 Cells: Functional Properties, Regulation of Development and Role in Autoimmunity. Autoimmunity 18:4, pages 301-308.
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C. M. Rotella, F. Dotta, E. Mannucci & U. Di Mario. (1992) Autoantigens in Thyroid and Islet Autoimmunity: Similarities and Differences. Autoimmunity 12:3, pages 223-237.
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Arianna Troilo, Alessia Grassi, Luisa Petrone, Fabio Cianchi, Marisa Benagiano, Chiara Della Bella, Nagaja Capitani, Jacopo Bitetti, Sofia D’Elios, Simona Tapinassi, Annalisa Azzurri, Heba Alnwaisri, Jacopo Romagnoli, Nicola Bizzaro, Mathijs Bergman, Cosima Tatiana Baldari & Mario Milco D’Elios. (2019) Intrinsic factor recognition promotes T helper 17/T helper 1 autoimmune gastric inflammation in patients with pernicious anemia. Oncotarget 10:30, pages 2921-2929.
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Giulia Di Dalmazi, Paulina Chalan & Patrizio Caturegli. (2019) MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-α Release. The Journal of Immunology 202:5, pages 1350-1362.
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Margret Ehlers & Matthias Schott. (2014) Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked?. Trends in Endocrinology & Metabolism 25:12, pages 656-664.
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Mario Rotondi, Francesca Coperchini, Patrizia Pignatti, Riccardo Sideri, Gloria Groppelli, Paola Leporati, Luigi La Manna, Flavia Magri, Stefano Mariotti & Luca Chiovato. (2013) Interferon-γ and Tumor Necrosis Factor-α Sustain Secretion of Specific CXC Chemokines in Human Thyrocytes: A First Step Toward a Differentiation between Autoimmune and Tumor-Related Inflammation?. The Journal of Clinical Endocrinology & Metabolism 98:1, pages 308-313.
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Claus H. Nielsen, Thomas H. Brix, R. Graham Q. Leslie & Laszlo Hegedüs. (2009) A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase. Clinical Immunology 133:2, pages 218-227.
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Eun-Ho Sa, Un-Ho Jin, Dong-Soo Kim, Bong-Seok Kang, Ki-Tae Ha, June-Ki Kim, Won-Hwan Park & Cheorl-Ho Kim. (2007) Herbal medicine Gamgungtang down-regulates autoimmunity through induction of TH2 cytokine production by lymphocytes in experimental thyroiditis model. Journal of Ethnopharmacology 109:3, pages 472-479.
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C H Nielsen, L Hegedüs, K Rieneck, A C Moeller, R G Q Leslie & K Bendtzen. (2007) Production of interleukin (IL)-5 and IL-10 accompanies T helper cell type 1 (Th1) cytokine responses to a major thyroid self-antigen, thyroglobulin, in health and autoimmune thyroid disease. Clinical and Experimental Immunology 147:2, pages 287-295.
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