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Autoimmunity Volume 5, 1989 - Issue 1-2
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Original Article

Evidence for a Potential Common T-Cell Epitope Between Human Thyroid Peroxidase and Human Thyroglobulin with Implications for the Pathogenesis of Autoimmune Thyroid Disease

Sandra Melissa Mclachlan The Endocrine Immunology Unit, Department of Medicine, University of Wales College of Medicine, Cardiff Wales
&
Basil Rapoport The Endocrine Immunology Unit Department of Medicine, University of California, San Francisco
Pages 101-106 | Received 24 May 1989, Accepted 20 Jun 1989, Published online: 07 Jul 2009

Citations (34)

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Sandra M. McLachlan & Basil Rapoport. (2000) Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator. International Reviews of Immunology 19:6, pages 587-618.
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C. M. Rotella, F. Dotta, E. Mannucci & U. Di Mario. (1992) Autoantigens in Thyroid and Islet Autoimmunity: Similarities and Differences. Autoimmunity 12:3, pages 223-237.
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J. P. Banga, P. S. Barnett & A. M. McGregor. (1991) Immunological and Molecular Characteristics of the Thyroid Peroxidase Autoantigen. Autoimmunity 8:4, pages 335-343.
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Bjöurn E. Wenzel, Thomas F. Franke, Armin E. Heufelder & JÜrgen Heesemann. (1990) Autoimmune Thyroid Diseases and Enteropathogenic Yersinia Enterocolitica. Autoimmunity 7:4, pages 295-303.
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Marian Ludgate & Gilbert Vassart. (1990) The Molecular Genetics of Three Thyroid Autoantigens: Thyroglobulin, Thyroid Peroxidase and the Thyrotropin Receptor. Autoimmunity 7:2-3, pages 201-211.
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Articles from other publishers (29)

Elena P. Kiseleva, Konstantin I. Mikhailopulo, Evelina L. Zdorovenko, Yuriy A. Knirel & Galina I. Novik. (2017) Linear α-(1 → 6)- d -glucan from Bifidobacterium bifidum BIM В-733D is low molecular mass biopolymer with unique immunochemical properties. Carbohydrate Research.
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Sandra M. McLachlan & Basil Rapoport. (2014) Breaking Tolerance to Thyroid Antigens: Changing Concepts in Thyroid Autoimmunity. Endocrine Reviews 35:1, pages 59-105.
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E.P. Kiseleva, K.I. Mikhailopulo, G.I. Novik, E. Szwajcer Dey, E.L. Zdorovenko, A.S. Shashkov & Y.A. Knirel. (2013) Isolation and structural identification of glycopolymers of Bifidobacterium bifidum BIM B-733D as putative players in pathogenesis of autoimmune thyroid diseases . Beneficial Microbes 4:4, pages 375-391.
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Marc Feldmann. (2009) Translating Molecular Insights in Autoimmunity into Effective Therapy. Annual Review of Immunology 27:1, pages 1-27.
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J RUF, M FERRAND, J M DURAND-GORDE, C DE MICCO & P CARAYON. (1993) Significance of thyroglobulin antibodies cross-reactive with thyroperoxidase (TGPO antibodies) in individual patients and immunized mice. Clinical and Experimental Immunology 92:1, pages 65-72.
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D L EWINS, P S BARNETT, S RATANACHAIYAVONG, C SHARROCK, J LANCHBURY, A M McGREGOR & J P BANGA. (1992) Antigen-specific T cell recognition of affinity-purified and recombinant thyroid peroxidase in autoimmune thyroid disease. Clinical and Experimental Immunology 90:1, pages 93-98.
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M HENRY, E ZANELLI & Y MALTHIERY. (1991) Anti-human thyroid peroxidase and anti-human thyroglobulin antibodies present no cross-reactivity on recombinant peptides. Clinical and Experimental Immunology 86:3, pages 478-482.
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N FUKUMA, S M MCLACHLAN, B RAPOPORT, J GOODACRE, S L MIDDLETON, D I W PHILLIPS, C A S PEGG & B REES SMITH. (1990) Thyroid autoantigens and human T cell responses. Clinical and Experimental Immunology 82:2, pages 275-283.
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Philip F. Watson & Nagat Saeed. 2008. Autoimmune Diseases in Endocrinology. Autoimmune Diseases in Endocrinology 95 116 .
Sandra M. McLachlanBasil Rapoport. (2007) Thyroid Peroxidase as an Autoantigen. Thyroid 17:10, pages 939-948.
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D. Thomas, V. Liakos, E. Vassiliou, F. Hatzimarkou, A. Tsatsoulis & P. Kaldrimides. (2014) Possible reasons for different pattern disappearance of thyroglobulin and thyroid peroxidase autoantibodies in patients with differentiated thyroid carcinoma following total thyroidectomy and iodine-131 ablation. Journal of Endocrinological Investigation 30:3, pages 173-180.
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Salvatore BenvengaLibero SantarpiaFrancesco TrimarchiFabrizio Guarneri. (2006) Human Thyroid Autoantigens and Proteins of Yersinia and Borrelia Share Amino Acid Sequence Homology That Includes Binding Motifs to HLA-DR Molecules and T-Cell Receptor . Thyroid 16:3, pages 225-236.
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Jean Ruf & Pierre Carayon. (2006) Structural and functional aspects of thyroid peroxidase. Archives of Biochemistry and Biophysics 445:2, pages 269-277.
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Salvatore BenvengaFabrizio GuarneriMario VaccaroLibero SantarpiaFrancesco Trimarchi. (2004) Homologies Between Proteins of Borrelia burgdorferi and Thyroid Autoantigens . Thyroid 14:11, pages 964-966.
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Jin Guo, Pavel N. Pichurin, John C. Morris, Basil Rapoport & Sandra M. McLachlan. (2004) “Naked” Deoxyribonucleic Acid Vaccination Induces Recognition of Diverse Thyroid Peroxidase T Cell Epitopes. Endocrinology 145:8, pages 3671-3678.
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Sandra M. McLachlan & Basil Rapoport. (2004) Why Measure Thyroglobulin Autoantibodies Rather Than Thyroid Peroxidase Autoantibodies?. Thyroid 14:7, pages 510-520.
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Francesco Latrofa, Pavel Pichurin, Jin Guo, Basil Rapoport & Sandra M. McLachlan. (2003) Thyroglobulin-Thyroperoxidase Autoantibodies Are Polyreactive, Not Bispecific: Analysis Using Human Monoclonal Autoantibodies. The Journal of Clinical Endocrinology & Metabolism 88:1, pages 371-378.
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Christine Duthoit, Valérie Estienne, Frédéric Delom, Josée-Martine Durand-Gorde, Bernard Mallet, Pierre Carayon & Jean Ruf. (2000) Production of Immunoreactive Thyroglobulin C-Terminal Fragments during Thyroid Hormone Synthesis. Endocrinology 141:7, pages 2518-2525.
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Salvatore Benvenga, S. Alesci, F. Trimarchi & A. Facchiano. (2014) Homologies of the thyroid sodium-iodide symporter with bacterial and viral proteins. Journal of Endocrinological Investigation 22:7, pages 535-540.
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JUNTA TAKAMATSU, SHIGERU YOSHIDA, TAMOTSU YOKOZAWA, KEISUKE HIRAI, KANJI KUMA, NAKAAKI OHSAWA & TOICHIRO HOSOYA. (1998) Correlation of Antithyroglobulin and Antithyroid-Peroxidase Antibody Profiles with Clinical and Ultrasound Characteristics of Chronic Thyroiditis. Thyroid 8:12, pages 1101-1106.
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Maria Elena Fisfalen, Ellen M. Palmer, Gijs A. van Seventer, Keyoumars Soltani, Yoshikuni Sawai, Edwin Kaplan, Yoh Hidaka, Carole Ober & Leslie J. DeGroot. (1997) Thyrotropin-Receptor and Thyroid Peroxidase-Specific T Cell Clones and Their Cytokine Profile in Autoimmune Thyroid Disease1. The Journal of Clinical Endocrinology & Metabolism 82:11, pages 3655-3663.
Crossref
S. Benvenga, L. Bartolone & F. Trimarchi. (2014) Thyroid iodide transporter: Local sequence homologies with thyroid autoantigens. Journal of Endocrinological Investigation 20:9, pages 508-512.
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Sudershan K. Bhatia & Noel R. Rose. 1996. Immunobiology. Immunobiology 239 263 .
I. Kothbauer-Margreiter, M. Sturzenegger, J. Komor, R. Baumgartner & C. W. Hess. (1996) Encephalopathy associated with Hashimoto thyroiditis: Diagnosis and treatment. Journal of Neurology 243:8, pages 585-593.
Crossref
S. M. McLACHLAN & B. RAPOPORT. (2009) Autoimmune endocrinopathies 2 Recombinant thyroid autoantigens: the keys to the pathogenesis of autoimmune thyroid disease. Journal of Internal Medicine 234:4, pages 347-359.
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Akira Hoshioka, Yoichi Kohno, Toshiyuki Katsuki, Naoki Shimojo, Naoki Maruyama, Yoshimasa Inagaki, Takashi Yokochi, Osamu Tarutani, Toichiro Hosoya & Hiroo Niimi. (1993) A common T-cell epitope between human thyroglobulin and human thyroid peroxidase is related to murine experimental autoimmune thyroiditis. Immunology Letters 37:2-3, pages 235-239.
Crossref
C.Lynne Burek. (1993) Thyroglobulin, a major thyroid antigen. Clinical Immunology Newsletter 13:4, pages 37-44.
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B. E. Wenzel, R. Gutekunst & J. Heesemann. 1991. Autoimmune Thyroiditis. Autoimmune Thyroiditis 205 213 .
N. Fukuma, S. McLachlan, D. I. W. Phillips, C. A. S. Pegg, B. Rapoport & B. Rees Smith. 1991. Autoimmune Thyroiditis. Autoimmune Thyroiditis 123 130 .

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