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Autoimmunity Volume 3, 1989 - Issue 3
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Original Article

Definition, at the Molecular Level, of a Thyroglobulin—Acetylcholinesterase Shared Epitope: Study of its Pathophysiological Significance in Patients with Graves' Ophthalmopathy

M. Ludgate IRIBHN, ULB, 1070, Brussels, Belgium
,
Q. Dong IRIBHN, ULB, 1070, Brussels, Belgium
,
P. A. Dreyfus Dept Biol. Chem, Hebrew University of Jerusalem, Israel
,
H. Zakut Dept Obst. Gynaecol, The Edith Wolfson Med. Centre, Tel Aviv Univ., Israel
,
P. Taylor Dept Pharmacology, University San Diego, California, USA
,
G. Vassart IRIBHN, ULB, 1070, Brussels, Belgium
&
H. Soreq Dept Biol. Chem, Hebrew University of Jerusalem, Israel
 show all
Pages 167-176 | Received 28 Sep 1988, Accepted 31 Dec 1988, Published online: 07 Jul 2009

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J. Geen, R.C. Howells, M. Ludgate, D.A. Hullin & S.I. Hogg. (2004) The Prevalence of Anti-acetylcholinesterase Antibodies in Autoimmune Disease. Autoimmunity 37:8, pages 579-585.
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C. M. Rotella, F. Dotta, E. Mannucci & U. Di Mario. (1992) Autoantigens in Thyroid and Islet Autoimmunity: Similarities and Differences. Autoimmunity 12:3, pages 223-237.
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A. P. Weetman. (1992) The Role of T Lymphocytes in Thyroid-Associated Ophthalmopathy. Autoimmunity 13:1, pages 69-73.
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Marian Ludgate & Gilbert Vassart. (1990) The Molecular Genetics of Three Thyroid Autoantigens: Thyroglobulin, Thyroid Peroxidase and the Thyrotropin Receptor. Autoimmunity 7:2-3, pages 201-211.
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Articles from other publishers (30)

R. A. Ajjan & A. P. Weetman. 2018. Thyroid Diseases. Thyroid Diseases 57 87 .
Serge Nataf. (2017) Evolution, immunity and the emergence of brain superautoantigens. F1000Research 6, pages 171.
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R. A. Ajjan & A. P. Weetman. 2016. Thyroid Diseases. Thyroid Diseases 1 31 .
Carlo Provenzano, Mariapaola Marino, Flavia Scuderi, Amelia Evoli & Emanuela Bartoccioni. (2010) Anti-acetylcholinesterase antibodies associate with ocular myasthenia gravis. Journal of Neuroimmunology 218:1-2, pages 102-106.
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Michael T. Stang & John H. Yim. 2005. Measuring Immunity. Measuring Immunity 543 559 .
Sandra M. McLachlan & Basil Rapoport. (2004) Why Measure Thyroglobulin Autoantibodies Rather Than Thyroid Peroxidase Autoantibodies?. Thyroid 14:7, pages 510-520.
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Fabrizio Gentile, Marisa Conte & Silvestro Formisano. (2004) Thyroglobulin as an autoantigen: what can we learn about immunopathogenicity from the correlation of antigenic properties with protein structure?. Immunology 112:1, pages 13-25.
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Bellur S. Prabhakar, Rebecca S. Bahn & Terry J. Smith. (2003) Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy. Endocrine Reviews 24:6, pages 802-835.
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A THRASYVOULIDES & P LYMBERI. (2003) Evidence for intramolecular B-cell epitope spreading during experimental immunization with an immunogenic thyroglobulin peptide. Clinical and Experimental Immunology 132:3, pages 401-407.
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M LUDGATE & G BAKER. (2002) Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease. Clinical and Experimental Immunology 127:2, pages 193-198.
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Basil Rapoport & Sandra M. McLachlan. (2001) Keeping Our Eyes Open. Thyroid 11:2, pages 165-166.
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Anthony P. Weetman, E. Helen Kemp, Jonathan N. Ridgway & Philip F. Watson. 2001. Thyroid Eye Disease. Thyroid Eye Disease 1 20 .
D.H.C. KHOO, S.C. HO, L.L. SEAH, K.S. FONG, E.S. TAI, S.P. CHEE, P.H.K. ENG, S.E. AW & A.C.K. FOK. (1999) The Combination of Absent Thyroid Peroxidase Antibodies and High Thyroid-Stimulating Immunoglobulin Levels in Graves' Disease Identifies a Group at Markedly Increased Risk of Ophthalmopathy. Thyroid 9:12, pages 1175-1180.
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Dan Grisaru, Meira Sternfeld, Amiram Eldor, David Glick & Hermona Soreq. (2001) Structural roles of acetylcholinesterase variants in biology and pathology. European Journal of Biochemistry 264:3, pages 672-686.
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Anthony P. Weetman. 1999. Autoimmune Endocrinopathies. Autoimmune Endocrinopathies 245 270 .
M. Ludgate. 1998. Endocrine Autoimmunity and Associated Conditions. Endocrine Autoimmunity and Associated Conditions 25 38 .
Peter Laing, John G. Knight, Pádraig Wright & William L. Irving. 1995. Neural Development and Schizophrenia. Neural Development and Schizophrenia 215 246 .
Mark F. Prummel, Gregorio Chazenbalk, Juan Carlos Jaume, Basil Rapoport & Sandra M. McLachlan. (1994) Profile of lambda light chain variable region genes in graves' orbital tissue. Molecular Immunology 31:11, pages 793-802.
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Petros Perros & Pat Kendall-Taylor. (1993) Pathogenesis of thyroid-associated ophthalmopathy. Trends in Endocrinology & Metabolism 4:8, pages 270-275.
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Jean Massoulié, Leo Pezzementi, Suzanne Bon, Eric Krejci & François-Marie Vallette. (1993) Molecular and cellular biology of cholinesterases. Progress in Neurobiology 41:1, pages 31-91.
Crossref
R. Elisei, D. Weightman, P. Kendall-Taylor, G. Vassart & M. Ludgate. (2014) Muscle autoantigens in thyroid associated ophthalmopathy: The limits of molecular genetics. Journal of Endocrinological Investigation 16:7, pages 533-540.
Crossref
JUAN CARLOS JAUME, MARK F. PRUMMEL, WILMAR M. WIERSINGA, SANDRA M. MCLACHLAN & BASIL RAPOPORT. (1993) Thyrotropin Receptor Autoantibodies Recognizing Two Different Epitopes on the TSH Receptor: Lack of Relationship to Patient Age, Sex, and Ophthalmopathy. Thyroid 3:4, pages 291-295.
Crossref
E. Heilbronn. 1993. Cholinergic Function and Dysfunction. Cholinergic Function and Dysfunction 133 138 .
P. PERROS & P. KENDALL‐TAYLOR. (2009) Pathogenetic mechanisms in thyroid‐associated ophthalmopathy. Journal of Internal Medicine 231:3, pages 205-211.
Crossref
N. Bromberg, J. H. Romaldini, R. S. Werner, J. A. Sgarbi & M. C. Werner. (2014) The evolution of Graves’ ophthalmopathy during treatment with antithyroid drug alone and combined with triiodothyronine. Journal of Endocrinological Investigation 15:3, pages 191-195.
Crossref
Z.-G. Zhang, M. Salvi, A. Miller, N. Bernard, B. Arthurs & J.R. Wall. (1992) Restricted tissue reactivity of autoantibodies to a 64-kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy. Clinical Immunology and Immunopathology 62:2, pages 183-189.
Crossref
A.P Weetman. (1991) Thyroid-associated eye disease: pathophysiology. The Lancet 338:8758, pages 25-28.
Crossref
MARIO SALVI, NICOLE BERNARD, ANNE MILLER, ZHI-GUONG ZHANG, ELIANA GARDINI & JACK R. WALL. (1991) Prevalence of Antibodies Reactive with a 64 kDa Eye Muscle Membrane Antigen in Thyroid-Associated Ophthalmopathy. Thyroid 1:3, pages 207-213.
Crossref
Jack R. Wall, Mario Salvi, Nicole F. Bernard, Andrée Boucher & David Haegert. (1991) Thyroid-associated ophthalmopathy — a model for the association of organ-specific autoimmune disorders. Immunology Today 12:5, pages 150-153.
Crossref
M. Ludgate & G. Vassart. 1990. The Molecular Biology of Autoimmune Disease. The Molecular Biology of Autoimmune Disease 109 120 .

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