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Autoimmunity Volume 8, 1990 - Issue 2
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Original Article

A Human Anti-Cardiolipin Autoantibody is Encoded by Developmentally restricted Heavy and Light Chain Variable Region Genes

Katherine a. Siminovitch Department of Medicine, University of Toronto, Toronto, Ontario, M5G 1X5, Canada; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
,
Virginia Misener Department of Medicine, University of Toronto, Toronto, Ontario, M5G 1X5, Canada; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
,
Pak C. Kwong Department of Medicine, University of Toronto, Toronto, Ontario, M5G 1X5, Canada; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
,
Pei-Ming Yang Department of Medicine, University of Toronto, Toronto, Ontario, M5G 1X5, Canada; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
,
Carl A. Laskin Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
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Ewa Cairns Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
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David Bell Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
,
Laurence A. Rubin Department of Medicine, University of Toronto, Toronto, Ontario, M5G 1X5, Canada; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
&
Pojen P. Chen Department of Medicine, University of Toronto, Toronto, Ontario, M5G 1X5, Canada; Department of Medicine, University of Western Ontario, London, Ontario, N6A 5A5
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Pages 97-105 | Received 04 Jun 1990, Published online: 07 Jul 2009

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Arthur Hohmann, Ewa Cairns, Michael Brisco, David A. Bell & Betty Diamond. (1995) Immunoglobulin Gene Sequence Anlaysis of Anti-Cardiolipin and Anti-Cardiolipin Idiotype (H3) Human Monoglonal Antibodies. Autoimmunity 22:1, pages 49-57.
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Hwee-Ming Cheng. (1994) Cryptic Antiphospholipid Autoantibodies and Serum Co-Inhibitors. Autoimmunity 19:2, pages 127-133.
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Articles from other publishers (23)

I Giles, A Lambrianides & A Rahman. (2008) Examining the non-linear relationship between monoclonal antiphospholipid antibody sequence, structure and function. Lupus 17:10, pages 895-903.
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M D DALEY, V MISENER, T OLEE, P P CHEN & K A SIMINOVITCH. (1993) Genetic analysis of the variable region genes encoding a monospecific human natural anti-DNA antibody. Clinical and Experimental Immunology 93:1, pages 11-18.
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X MARIETTE, Y LEVY, M-L DUBREUIL, L INTRATOR, F DANON & J-C BROUET. (1993) Characterization of a human monoclonal autoantibody directed to cardiolipin/β2 glycoprotein I produced by chronic lymphocytic leukaemia B cells. Clinical and Experimental Immunology 94:2, pages 385-390.
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George F. WidhopfIIII, Craig J. GoldbergTraci L. ToyLaura Z. RassentiWilliam G. WierdaJohn C. ByrdMichael J. KeatingJohn G. Gribben, Kanti R. Rai & Thomas J. Kipps. (2008) Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3. Blood 111:6, pages 3137-3144.
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Ian P. Giles, David A. Isenberg & Anisur Rahman. 2006. Hughes Syndrome. Hughes Syndrome 470 491 .
George F. WidhopfIIIILaura Z. RassentiTraci L. ToyJohn G. GribbenWilliam G. WierdaThomas J. Kipps. (2004) Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 104:8, pages 2499-2504.
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George F. WidhopfIIII, Diana C. Brinson, Thomas J. Kipps & Helen Tighe. (2004) Transgenic Expression of a Human Polyreactive Ig Expressed in Chronic Lymphocytic Leukemia Generates Memory-Type B Cells That Respond to Nonspecific Immune Activation. The Journal of Immunology 172:4, pages 2092-2099.
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CONSTANTIN A. BONA & FREDA K. STEVENSON. 2004. Molecular Biology of B Cells. Molecular Biology of B Cells 381 401 .
Ian P. Giles, Joanna D. Haley, Sylvia Nagl, David A. Isenberg, David S. Latchman & Anisur Rahman. (2003) A systematic analysis of sequences of human antiphospholipid and anti–β2-glycoprotein I antibodies: The importance of somatic mutations and certain sequence motifs. Seminars in Arthritis and Rheumatism 32:4, pages 246-265.
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Harald Burkhardt & Reinhard E. Voll. 2003. Molekularmedizinische Grundlagen von rheumatischen Erkrankungen. Molekularmedizinische Grundlagen von rheumatischen Erkrankungen 165 211 .
George F. WidhopfIIII & Thomas J. Kipps. (2001) Normal B Cells Express 51p1 -Encoded Ig Heavy Chains That Are Distinct From Those Expressed by Chronic Lymphocytic Leukemia B Cells . The Journal of Immunology 166:1, pages 95-102.
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A. Rahman & D. Isenberg. 2000. Hughes Syndrome. Hughes Syndrome 358 371 .
Miri Blank, Ari Waisman, Edna Mozes, Takao Koike & Yehuda Shoenfeld. (1999) Characteristics and pathogenic role of anti-β2-glycoprotein I single-chain Fv domains: induction of experimental antiphospholipid syndrome. International Immunology 11:12, pages 1917-1926.
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Reginald U. Chukwuocha, Elie T. Hsiao, Peter Shaw, Joseph L. Witztum & Pojen P. Chen. (1999) Isolation, Characterization and Sequence Analysis of Five IgG Monoclonal Anti-β2-Glycoprotein-1 and Anti-Prothrombin Antigen-Binding Fragments Generated by Phage Display. The Journal of Immunology 163:8, pages 4604-4611.
Crossref
Hans‐Peter Brezinschek, Ruth I Brezinschek, Thomas DÖrner & Peter E Lipsky. (2001) Similar characteristics of the CDR3 of V H 1‐69/DP‐10 rearrangements in normal human peripheral blood and chronic lymphocytic leukaemia B cells . British Journal of Haematology 102:2, pages 516-521.
Crossref
D.A. Isenberg, C.T. Ravirajan, A. Rahman & J. Kalsi. (2016) The role of antibodies to DNA in systemic lupus erythematosus— A review and introduction to an international workshop on DNA antibodies held in London, May 1996. Lupus 6:3, pages 290-304.
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S Menon, M.A.A Rahman, C.T Ravirajan, D Kandiah, C.M Longhurst, T McNally, W.M Williams, D.S Latchman & D.A Isenberg. (1997) The Production, Binding Characteristics and Sequence Analysis of Four Human IgG Monoclonal Antiphospholipid Antibodies. Journal of Autoimmunity 10:1, pages 43-57.
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Anisur Rahman, Sanjeev Menon, David S. Latchman & David A. Isenberg. (1996) Sequences of monoclonal antiphospholipid antibodies: variations on an anti-DNA antibody theme. Seminars in Arthritis and Rheumatism 26:2, pages 515-525.
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P.‐M. YANG, T. OLEE, D. A. CARSON & P. P. CHEN. (2008) Characterization of Two Highly Homologous Autoantibody‐Related VHl Genes in Humans. Scandinavian Journal of Immunology 37:4, pages 504-508.
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Vincent Hurez, Srinivas‐ V. Kaveri & Michel D. Kazatchkine. (2005) Expression and control of the natural autoreactive IgG repertoire in normal human serum. European Journal of Immunology 23:4, pages 783-789.
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INGRID RANDEN, KEITHM. THOMPSON, VIRGINIA PASCUAL, KIMBFRLY VICTOR, DENNIS BHALR, JOHN COADWELL, ØYSTEIN FORRE, J. DONALD CAPRA & JACOBB. NATVIG. (2006) Rheumatoid Factor V Genes from Patients with Rheumatoid Arthritis are Diverse and Show Evidence of an Antigen‐Driven Response. Immunological Reviews 128:1, pages 49-71.
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Ton LOGTENBERG, MIEKEE. M. SSCHUTTE, SASKIA B. EBELING, FRITS H. J. GMELIG‐MEYLING & JOHAN H. VAN ES. (2006) Molecular Approaches to the Study of Human B‐Cell and (Auto)antibody Repertoire Generation and Selection. Immunological Reviews 128:1, pages 23-47.
Crossref
M. M. NEWKIRK. (2006) Complete Amino Acid Sequence of the Variable Regions of Two Highly Related Heavy and Light Chains of Human IgG (SFL) and IgM (RIV) Rheumatoid Factors. Scandinavian Journal of Immunology 35:6, pages 651-658.
Crossref

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