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Original Article

Interleukin 6: A Functional and Structural in Vitro Modulator of Beta-Cells from Islets of Langerhans

, , , &
Pages 185-194 | Received 29 May 1989, Accepted 03 Aug 1989, Published online: 07 Jul 2009

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Karsten Buschard, Charlotte Pedersen, Susanne V. Hansen, Ida Hageman, Kim Aaen & Klaus Bendtzen. (1992) Anti-Diabetogenic Effect of Fusidic Acid in Diabetes Prone Bb Rats. Autoimmunity 14:2, pages 101-104.
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Stellan Sandler, Décio L. Eizirik, Carina Svensson, Eva Strandell, Michael Welsh & Nils Welsh. (1991) Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells. Autoimmunity 10:3, pages 241-253.
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. (1990) Symposium 10: Inter- and Intracellular Signal Systems 11. Scandinavian Journal of Clinical and Laboratory Investigation 50:sup202, pages 159-171.
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Yu-Liang Sun, Ling-Rui Shang, Rui-Hong Liu, Xin-Yi Li, Sheng-Hui Zhang, Ya-Kun Ren, Kang Fu, Hong-Bin Cheng, Badrul Hisham Yahaya, Yan-Li Liu & Jun-Tang Lin. (2022) Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes. World Journal of Stem Cells 14:1, pages 104-116.
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Amina Nadeem. (2017) Inter-Ethnic Variations in Association of TNF-Alpha G308a Single Nucleotide Polymorphism with Type 2 Diabetes Mellitus - A Review. Journal of Diabetes, Metabolic Disorders & Control 4:2.
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Karsten Buschard, Austin W. Bracey, Daniel L. McElroy, Andrew T. Magis, Thomas Osterbye, Mark A. Atkinson, Kate M. Bailey, Amanda L. Posgai & David A. Ostrov. (2016) Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface. Journal of Diabetes Research 2016, pages 1-4.
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Johanna Bodin, Anette Kocbach Bølling, Anna Wendt, Lena Eliasson, Rune Becher, Frieke Kuper, Martinus Løvik & Unni Cecilie Nygaard. (2015) Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice. Toxicology Reports 2, pages 99-110.
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Jesper Larsen, Morten Dall, Julie Christine Antvorskov, Christian Weile, Kåre Engkilde, Knud Josefsen & Karsten Buschard. (2014) Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion. European Journal of Immunology 44:10, pages 3056-3067.
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Amina Nadeem, Abdul Khaliq Naveed, Muhammad Mazhar Hussain, Muhammad Aslam, Arif Siddiqui & Sheikh Abdul Saeed. (2013) Variations in association of Interleukin 6 -G174C single nucleotide polymorphism with type 2 diabetes mellitus—a review. International Journal of Diabetes in Developing Countries 33:4, pages 186-191.
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Mette Ladefoged, Karsten Buschard & Ann Maria Kruse Hansen. (2012) Increased expression of toll‐like receptor 4 and inflammatory cytokines, interleukin‐6 in particular, in islets from a mouse model of obesity and type 2 diabetes. APMIS 121:6, pages 531-538.
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Rhianna C. LakerLinda A. GalloMary E. WlodekAndrew L. SiebelGlenn D. Wadley & Glenn K. McConell. (2011) Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats. American Journal of Physiology-Endocrinology and Metabolism 301:5, pages E931-E940.
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Toshinobu Suzuki, Junta Imai, Tetsuya Yamada, Yasushi Ishigaki, Keizo Kaneko, Kenji Uno, Yutaka Hasegawa, Hisamitsu Ishihara, Yoshitomo Oka & Hideki Katagiri. (2011) Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells. Diabetes 60:2, pages 537-547.
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Jolanta Myśliwska, Katarzyna Zorena, Małgorzata Myśliwiec, Ewa Malinowska, Krystyna Raczyńska & Anna Balcerska. (2009) The −174GG Interleukin-6 Genotype Is Protective From Retinopathy and Nephropathy in Juvenile Onset Type 1 Diabetes Mellitus. Pediatric Research 66:3, pages 341-345.
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Francesco Andreozzi, Emanuela Laratta, Marina Cardellini, Maria A. Marini, Renato Lauro, Marta L. Hribal, Francesco Perticone & Giorgio Sesti. (2006) Plasma Interleukin-6 Levels Are Independently Associated With Insulin Secretion in a Cohort of Italian-Caucasian Nondiabetic Subjects. Diabetes 55:7, pages 2021-2024.
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E. W. Petersen, A. L. Carey, M. Sacchetti, G. R. Steinberg, S. L. Macaulay, M. A. Febbraio & B. K. Pedersen. (2005) Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro. American Journal of Physiology-Endocrinology and Metabolism 288:1, pages E155-E162.
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MARIA BLOMQVIST, THOMAS OSTERBYE, JAN‐ERIC MÅNSSON, THOMAS HORN, KARSTEN BUSCHARD & PAM FREDMAN. (2003) Selective lack of the C16:0 fatty acid isoform of sulfatide in pancreas of type II diabetic animal models. APMIS 111:9, pages 867-877.
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Karsten Buschard, Marcus Diamant, Lone F. Bovin, Jan‐Eric MÅNsson, Ram Fredman & Klaus Bendtzen. (2009) Sulphatide and its precursor galactosylceramide influence the production of cytokines in human mononuclear cells. APMIS 104:7-8, pages 938-944.
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Eva Strandell, Karsten Buschard, Johan Saldeen & Nils Welsh. (1995) Interleukin-1β induces the expression of HSP70, heme oxygenase and Mn-SOD in FACS-purified rat islet β-cells, but not in α-cells. Immunology Letters 48:2, pages 145-148.
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Thomas Olencki, James Finke & Ronald M. Bukowski. (2012) Interleukin-6. Clinical Immunotherapeutics 2:4, pages 278-294.
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K. Buschard, K. Josefsen, S. V. Hansen, T. Horn, M. O. Marshall, H. Persson, J. -E. M�nsson & P. Fredman. (1994) Sulphatide in islets of Langerhans and in organs affected in diabetic late complications: a study in human and animal tissue. Diabetologia 37:10, pages 1000-1006.
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T. Horn, K. Bendtzen, I. Hageman & K. Buschard. (2009) Morphological Effects of Sodium Fusidate (Fusidin) on Pancreatic Islet Cells: An Electron Microscopic study. Pharmacology & Toxicology 75:3-4, pages 228-230.
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T. H. Jones. (2008) Interleukin‐6 an endocrine cytokine. Clinical Endocrinology 40:6, pages 703-713.
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Stellan Sandler, Karsten Buschard & Klaus Bendtzen. (1994) Effects of 1,25-dihydroxyvitamin D3 and the analogues MC903 and KH1060 on interleukin-1β-induced inhibition of rat pancreatic islet β-cell function in vitro. Immunology Letters 41:1, pages 73-77.
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KARSTEN BUSCHARD, KNUD JOSEFSEN, THOMAS HORN, SVEND LARSEN & PAM FREDMAN. (1993) Sulphatide antigen in islets of Langerhans and in diabetic glomeruli, and anti-sulphatide antibodies in Type 1 diabetes mellitus. APMIS 101:7-12, pages 963-970.
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Marie-Annick Lety, Josiane Coulaud, Marcelle Bens, Mireille Dardenne & Françoise Homo-Delarche. (1992) Enhanced metabolism of arachidonic acid by macrophages from nonobese diabetic (NOD) mice. Clinical Immunology and Immunopathology 64:3, pages 188-196.
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T. W. KJAER, J. RYGAARD, K. BENDTZEN, K. JOSEFSEN, T. BOCK & K. BUSCHARD. (2009) Interleukins increase surface ganglioside expression of pancreatic islet cells in vitro . APMIS 100:1-6, pages 509-514.
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Åke Sjöholm. (1991) Cytokines inhibit proliferation and insulin secretion by clonal rat insulinoma cells (RINm5F) non-synergistically and in a pertussis toxin-insensitive manner. Immunology Letters 30:1, pages 81-86.
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