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Original Article

Cyclosporine-Induced Autoimmunity and Immune Hyperreactivity

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Pages 345-356 | Received 20 Jul 1990, Published online: 07 Jul 2009

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Hyun Goo Kang, Sung Kwang Park, Su Jeong Wang, Sun-Young Oh & Han Uk Ryu. (2018) Opsoclonus-myoclonus syndrome following long-term use of cyclosporine. Clinical Toxicology 56:5, pages 373-376.
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Patricia Rafferty, Devon Egenolf, Kerry Brosnan, Dorie Makropoulos, Jarrat Jordan, Kay Meshaw, Mindi Walker, Amy Volk & Peter J. Bugelski. (2012) Immunotoxicologic effects of cyclosporine on tumor progression in models of squamous cell carcinoma and B-cell lymphoma in C3H mice. Journal of Immunotoxicology 9:1, pages 43-55.
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Eric J. De Waal, Henk-Jan Schuurman, Henk van Loveren & Joseph G. Vos. (1997) Differential Effects of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin,bis(Tri-N-Butyltin)Oxide and Cyclosporine on Thymus Histophysiology. Critical Reviews in Toxicology 27:4, pages 381-430.
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Articles from other publishers (33)

Sarah S. Dinges, Kayla Amini, Luigi D. Notarangelo & Ottavia M. Delmonte. (2024) Primary and secondary defects of the thymus. Immunological Reviews 322:1, pages 178-211.
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Maria K. Lagou, Dimitra P. Anastasiadou & George S. Karagiannis. (2022) A Proposed Link Between Acute Thymic Involution and Late Adverse Effects of Chemotherapy. Frontiers in Immunology 13.
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Mahdieh Motiee, Ahmad Zavaran Hosseini & Sara Soudi. (2022) Evaluating the effects of Cyclosporine A immunosuppression on Mycobacterial infection by inhaling of Cyclosporine A administrated BALB/c mice with live Bacillus Calmette Guérin. Tuberculosis 132, pages 102163.
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Isaac Park, Tra Mi Phan & Jing Fang. (2021) Novel Molecular Mechanism of Lenalidomide in Myeloid Malignancies Independent of Deletion of Chromosome 5q. Cancers 13:20, pages 5084.
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Christian A. Devaux, Cléa Melenotte, Marie-Dominique Piercecchi-Marti, Clémence Delteil & Didier Raoult. (2021) Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19?. Frontiers in Medicine 8.
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Raghu Ganugula, Meenakshi Arora, Dianxiong Zou, Sandeep K. AgarwalChandra Mohan & M. N. V. Ravi Kumar. (2020) A highly potent lymphatic system–targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus. Science Advances 6:24.
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Camila Flores, Guillemette Fouquet, Ivan Cruz Moura, Thiago Trovati Maciel & Olivier Hermine. (2019) Lessons to Learn From Low-Dose Cyclosporin-A: A New Approach for Unexpected Clinical Applications. Frontiers in Immunology 10.
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Luis Ibáñez‐Samaniego, Magdalena Salcedo, Javier Vaquero & Rafael Bañares. (2016) De novo autoimmune hepatitis after liver transplantation: A focus on glutathione S‐transferase theta 1. Liver Transplantation 23:1, pages 75-85.
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Helene Pendl •Ian Tizard. 2016. Current Therapy in Avian Medicine and Surgery. Current Therapy in Avian Medicine and Surgery 400 432 .
Devon D. Egenolf, Patricia Rafferty, Kerry Brosnan, Mindi Walker, Jarrat Jordan, Dorie Makropoulos, Karl Kavalkovich, Sharon Watson, Laura Johns, Amy Volk & Peter J. Bugelski. (2011) Development of a murine model of lymph node metastases suitable for immunotoxicity studies. Journal of Pharmacological and Toxicological Methods 63:3, pages 236-249.
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N Leung, J M Gloor, P G Dean, M Q Lacy, L F Porrata & M D Griffin. (2008) Acute cellular rejection in a renal allograft immediately following leukocyte engraftment after auto-SCT. Bone Marrow Transplantation 43:4, pages 345-346.
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D J Wheeler, A Robins, D I Pritchard, R V Bundick & F Shakib. (1995) Potentiation of in vitro synthesis of human IgE by cyclosporin A (CsA) . Clinical and Experimental Immunology 102:1, pages 85-90.
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R V Bundick, R I Craggs & E Holness. (1995) The effect of cyclosporin A, FK506, and rapamycin on the murine chronic graft- versus -host response—an in vivo model of Th2-like activity . Clinical and Experimental Immunology 99:3, pages 467-472.
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P SAÏ, O SENECAT, L MARTIGNAT & E GOUIN. (1994) Neonatal injections of cyclosporin enhance autoimmune diabetes in non-obese diabetic mice. Clinical and Experimental Immunology 97:1, pages 138-145.
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Rajni B. Sharma, C. Lynne Burek, Daniela Cihákova, Dolores B. Njoku & Noel R. Rose. 2008. Autoimmune Diseases in Endocrinology. Autoimmune Diseases in Endocrinology 35 75 .
Chun Zeng, Yu Zhen, Shang-an Shu, Tinghe Wu, Huanfa Yi, Zhe-Xiong Lian & Yong Zhao. (2007) The influence of cyclosporin A on lymphocyte attenuator expression. Journal of Autoimmunity 28:4, pages 234-244.
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Hongjun Wang, Liang Zhao, Zuyue Sun, Liguang Sun, Baojun Zhang & Yong Zhao. (2006) A Potential Side Effect of Cyclosporin A: Inhibition of CD4+CD25+ Regulatory T Cells in Mice. Transplantation 82:11, pages 1484-1492.
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Hélène Gary-Gouy, Alexander Sainz-Perez, Georges Bismuth, Ataollah Ghadiri, Brian A. Perrino & Ali Dalloul. (2006) Cyclosporin-A inhibits ERK phosphorylation in B cells by modulating the binding of Raf protein to Bcl2. Biochemical and Biophysical Research Communications 344:1, pages 134-139.
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Sandra Reichstetter, Nathan E. Standifer, Kelly A. Geubtner, Andrew W. Liu, Stacy L. Agar & William W. Kwok. (2006) Cytotoxic herpes simplex type 2‐specific, DQ0602‐restricted CD4 + T‐cell clones show alloreactivity to DQ0601 . Immunology 117:3, pages 350-357.
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A. Godkin, P. Openshaw & H. C. Thomas. (2005) Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant. Journal of Viral Hepatitis 12:6, pages 604-608.
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MASAKO OTANI, HISASHI SHIMOJO, SATOSHI SHIOZAWA & HIDEKAZU SHIGEMATSU. (2005) Renal involvement in bone marrow transplantation. Nephrology 10:5, pages 530-536.
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Vinícius Cotta‐de‐Almeida, Adriana Bonomo, Daniella Arêas Mendes‐da‐Cruz, Ingo Riederer, Juliana de Meis, Kátia Regina Ferreira Lima‐Quaresma, Adriana Vieira‐de‐Abreu, Déa Maria Serra Villa‐Verde & Wilson Savino. (2003) Trypanosoma cruzi infection modulates intrathymic contents of extracellular matrix ligands and receptors and alters thymocyte migration . European Journal of Immunology 33:9, pages 2439-2448.
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José L. Olivares, Feliciano J. Ramos, Teresa Olivé, Cristina Fillat & Manuel Bueno. (2002) Autoimmune Thyroiditis After Bone Marrow Transplantation in a Boy With Wiskott-Aldrich Syndrome. Journal of Pediatric Hematology/Oncology 24:9, pages 772-776.
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Hiroyasu Ogawa, Toshihiro Soma, Naoki Hosen, Toyoshi Tatekawa, Akihiro Tsuboi, Yusuke Oji, Hiroya Tamaki, Manabu Kawakami, Kazuhiro Ikegame, Masaki Murakami, Tatsuya Fujioka, Eui Ho Kim, Yoshihiro Oka & Haruo Sugiyama. (2002) Combination of tacrolimus, methotrexate, and methylprednisolone prevents acute but not chronic graft-versus-host disease in unrelated bone marrow transplantation. Transplantation 74:2, pages 236-243.
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Suzanne Kadereit, Margaret M Kozik, Gwendolyn R Junge, Robin E Miller, Laura F Slivka, Linda S Bos, Kathleen Daum-Woods, R.Michael Sramkoski, James W Jacobberger & Mary J Laughlin. (2001) Cyclosporin A effects during primary and secondary activation of human umbilical cord blood T lymphocytes. Experimental Hematology 29:7, pages 903-909.
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Norbert Frickhofen & Stephen J Rosenfeld. (2000) Immunosuppressive treatment of aplastic anemia with antithymocyte globulin and cyclosporine. Seminars in Hematology 37:1, pages 56-68.
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Catherine M. Meyers & Youkang Zhang. (1999) Immunomodulatory effects of interferon-γ on autoreactive nephritogenic T-cell clones. Kidney International 55:4, pages 1395-1406.
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Audrey H. Birnbaum, Keith J. Benkov, Nanci S. Pittman, Yvonne McFarlane-Ferreira, Joel R. Rosh & Neal S. LeLeiko. (1997) Recurrence of Autoimmune Hepatitis in Children After Liver Transplantation. Journal of Pediatric Gastroenterology &amp Nutrition 25:1, pages 20-25.
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Audrey H. Birnbaum, Keith J. Benkov, Nanci S. Pittman, Yvonne McFarlane‐Ferreira, Joel R. RoshNeal S. LeLeiko. (1997) Recurrence of Autoimmune Hepatitis in Children After Liver Transplantation. Journal of Pediatric Gastroenterology and Nutrition 25:1, pages 20-25.
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M.E.J. Billingham. 1995. Mechanisms and Models in Rheumatoid Arthritis. Mechanisms and Models in Rheumatoid Arthritis 389 409 .
Georg A. Holländer, Barbara E. Bierer & Steven J. Burakoff. (1994) Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. Transfusion Science 15:3, pages 207-220.
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N. Frickhofen, Z. J. Chen, N. S. Young, B. J. Cohen, H. Heimpel & J. L. Abkowitz. (2008) Parvovirus B19 as a cause of acquired chronic pure red cell aplasia. British Journal of Haematology 87:4, pages 818-824.
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M. MUSTAFA, P. DIENER, J.‐B. SUN, H. LINK & T. OLSSON. (2006) Immunopharmacologic Modulation of Experimental Allergic Encephalomyelitis: Low‐Dose Cyclosporin‐A Treatment Causes Disease Relapse and Increased Systemic T and B Cell‐Mediated Myelin‐Directed Autoimmunity. Scandinavian Journal of Immunology 38:6, pages 499-507.
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