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Autoimmunity Volume 10, 1991 - Issue 4
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Original Article

Repetitive Exposure of Pancreatic Islets to Interleukin-1β. An In Vitro Model of Pre-diabetes?

S. Helqvist Steno Memorial Hospital and Hagedorn Research Laboratory, Gentofte, Denmark
,
U. W. Zumsteg Steno Memorial Hospital and Hagedorn Research Laboratory, Gentofte, Denmark
,
G. A. Spinas Dept. für Innere Medizin, Abteilung für Endokrinologie Kantonspital, CH 4031, Basel, Switzerland
,
J. P. Palmer Veterans Administration, Medical Center, 1660 South Columbian Way, Seattle, WA, USA
,
T. Mandrup-Poulsen Steno Memorial Hospital and Hagedorn Research Laboratory, Gentofte, Denmark
,
J. Egeberg Department of Medical Anatomy B, Panum Institute, University of Copenhagen, Copenhagen, Denmark
&
J. Nerup Steno Memorial Hospital and Hagedorn Research Laboratory, Gentofte, Denmark
 show all
Pages 311-318 | Received 24 Apr 1991, Published online: 07 Jul 2009

Citations (12)

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Ji-Won Yoon, Hee-Sook Jun & Pere Santamaria. (1998) Cellular and Molecular Mechanisms for the Initiation and Progression of β Cell Destruction Resulting from the Collaboration Between Macrophages and T Cells. Autoimmunity 27:2, pages 109-122.
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Articles from other publishers (11)

S. Abdelli, J. Puyal, C. Bielmann, V. Buchillier, A. Abderrahmani, P. G. H. Clarke, J. S. Beckmann & C. Bonny. (2009) JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52:9, pages 1871-1880.
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N F Magitta, A S Bøe Wolff, S Johansson, B Skinningsrud, B A Lie, K-M Myhr, D E Undlien, G Joner, P R Njølstad, T K Kvien, Ø Førre, P M Knappskog & E S Husebye. (2008) A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes. Genes & Immunity 10:2, pages 120-124.
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Makarand V. Risbud, Mandar R. Bhonde & Ramesh R. Bhonde. (2001) Effect of chitosan-polyvinyl pyrrolidone hydrogel on proliferation and cytokine expression of endothelial cells: Implications in islet immunoisolation. Journal of Biomedical Materials Research 57:2, pages 300-305.
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R. Damaris MolanoThierry BerneyHua LiPierre CattanAntonello PileggiCaterina VizzardelliNorma S. KenyonCamillo RicordiLinda C. BurklyLuca Inverardi. (2001) Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation. Diabetes 50:2, pages 270-276.
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Monique R. Heitmeier & John A. Corbett. 2000. Nitric Oxide. Nitric Oxide 785 810 .
Lin Wang, Arin Bhattacharjee, Zhuang ZuoFuquan Hu, Richard E. HonkanenPer-Olof Berggren & Ming Li. (1999) A Low Voltage-Activated Ca2+ Current Mediates Cytokine-Induced Pancreatic β-Cell Death*. Endocrinology 140:3, pages 1200-1204.
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T. Mandrup-Poulsen. (1996) The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39:9, pages 1005-1029.
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J. Nerup, T. Mandrap-Poulsen, S. Helqvist, H. U. Andersen, F. Pociot, J. I. Reimers, B. G. Cuartero, A. E. Karlsen, U. Bjerre & T. Lorenzen. (1994) On the pathogenesis of IDDM. Diabetologia 37:S2, pages S82-S89.
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R. D. G. Leslie, P. Carotenuto & P. Pozzilli. (2009) New developments in non‐specific and semi‐specific immunosuppression in type I diabetes. Diabetes/Metabolism Reviews 9:4, pages 257-267.
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U. Zumsteg, J. I. Reimers, F. Pociot, L. M�rch, S. Helqvist, M. Brendel, R. Alejandro, T. Mandrup-Poulsen, C. A. Dinarello & J. Nerup. (1993) Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats. Diabetologia 36:8, pages 759-766.
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L. D. Wogensen, J. Reimers, J. Nerup, V. Kolb -Bachofen, K. -D. Kr�ncke, T. Almdal & T. Mandrup -Poulsen. (1992) Repetitive in vivo treatment with human recombinant interleukin-1? modifies Beta-cell function in normal rats. Diabetologia 35:4, pages 331-339.
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