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Autoimmunity Volume 8, 1991 - Issue 4
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Original Article

The Main Immunogenic Region of the Acetylcholine Receptor. Structure and Role in Myasthenia Gravis

S. J. Tzartosa Dept. of Biochemistry, Hellenic Pasteur Institute, 127, Vas, Sofias Ave., Athens, 11521, Greece
,
T. Barkasb Dept. of Biochemistry and Genetics, Medical School, Newcastle upon Tyne NE2 4HH, UK
,
M. T. Cungc Laboratoire de Chimie-Physique Macromoleculaire, CNRS-UA-494. ENS1C-INPL, BP 451, 54001, Nancy, France
,
A. Kordossia Dept. of Biochemistry, Hellenic Pasteur Institute, 127, Vas, Sofias Ave., Athens, 11521, Greece
,
H. Loutraria Dept. of Biochemistry, Hellenic Pasteur Institute, 127, Vas, Sofias Ave., Athens, 11521, Greece
,
M. Marraudc Laboratoire de Chimie-Physique Macromoleculaire, CNRS-UA-494. ENS1C-INPL, BP 451, 54001, Nancy, France
,
I. Papadoulia Dept. of Biochemistry, Hellenic Pasteur Institute, 127, Vas, Sofias Ave., Athens, 11521, Greece
,
C. Sakarellosd Dept. of Chemistry, University of loannina, Box 1186, 45110, Ioannina, Greece
,
D. Sophianosa Dept. of Biochemistry, Hellenic Pasteur Institute, 127, Vas, Sofias Ave., Athens, 11521, Greece
&
V. Tsikarisa Dept. of Biochemistry, Hellenic Pasteur Institute, 127, Vas, Sofias Ave., Athens, 11521, Greece
 show all
Pages 259-270 | Received 09 Feb 1990, Accepted 28 Aug 1990, Published online: 07 Jul 2009

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Jackie Palace, Angela Vincent, David Beeson & John Newsom-Davis. (1994) Immunogenicity of Human Recombinant Acetylcholine Receptor α Subunit: Cytoplasmic Epitopes Dominate the Antibody Response in four Mouse Strains. Autoimmunity 18:2, pages 113-119.
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Hakon Hofstad, Nils Erik Gilhus, Roald Matre & Johan A. Aarli. (1992) Non-Receptor Muscle Antibodies in Myasthenia Gravis are of Iggl and Igg4 Subclasses. Autoimmunity 12:4, pages 271-276.
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Y. Kiso, J. Furmaniak, C. Morteo & B. Rees Smith. (1992) Analysis of Carbohydrate Residues on Human Thyroid Peroxidase (Tpo) and Thyroglobulin (Tg) and Effects of Deglycosylation, Reduction and Unfolding on Autoantibody Binding. Autoimmunity 12:4, pages 259-269.
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D. I. Stott. (1992) Spectrotypes of Anti-Dna Antibodies Show that Anti-Dna-Secreting B-Cell Clones of Sle Patients are Restricted in Number, Stable and Long Lived. Autoimmunity 12:4, pages 249-258.
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Nick Willcox. (1992) The Third Euromyasthenia Conference; Meeting Report and Update on Myasthenia Research. Autoimmunity 11:3, pages 209-212.
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Articles from other publishers (43)

Hiroaki Yoshikawa. (2022) Autoimmunity to acetylcholine receptor channels. Neurology and Clinical Neuroscience 12:3, pages 143-149.
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Chuyu Wu, Mei-Ling Jiang, Tao Pang & Cun-Jin Zhang. 2024. Regulatory T Cells and Autoimmune Diseases. Regulatory T Cells and Autoimmune Diseases 267 281 .
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Manqiqige Su, Chongbo Zhao & Sushan Luo. (2022) Therapeutic potential of chimeric antigen receptor based therapies in autoimmune diseases. Autoimmunity Reviews 21:1, pages 102931.
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Athanasios Niarchos, Marios Zouridakis, Vassilis Douris, Assimina Georgostathi, Dimitra Kalamida, Alexandros Sotiriadis, Konstantinos Poulas, Kostas Iatrou & Socrates J. Tzartos. (2013) Expression of a Highly Antigenic and Native-Like Folded Extracellular Domain of the Human α1 Subunit of Muscle Nicotinic Acetylcholine Receptor, Suitable for Use in Antigen Specific Therapies for Myasthenia Gravis. PLoS ONE 8:12, pages e84791.
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Lin Chen. (2010) In pursuit of the high-resolution structure of nicotinic acetylcholine receptors. The Journal of Physiology 588:4, pages 557-564.
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Erdem Tüzün & Premkumar Christadoss. (2006) Unraveling myasthenia gravis immunopathogenesis using animal models. Drug Discovery Today: Disease Models 3:1, pages 15-20.
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Evdokia Protopapadakis, Anna Kokla, Socrates J. Tzartos & Avgi Mamalaki. (2005) Isolation and characterization of human anti-acetylcholine receptor monoclonal antibodies from transgenic mice expressing human immunoglobulin loci. European Journal of Immunology 35:6, pages 1960-1968.
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IRENE P STAFFORD & GARY A DILDY. (2005) Myasthenia Gravis and Pregnancy. Clinical Obstetrics and Gynecology 48:1, pages 48-56.
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Tali Feferman, Sin-Hyeog Im, Sara Fuchs & Miriam C Souroujon. (2003) Breakage of tolerance to hidden cytoplasmic epitopes of the acetylcholine receptor in experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 140:1-2, pages 153-158.
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Bianca M. Conti-Fine, Brenda Diethelm-Okita, Norma Ostlie, Wei Wang & Monica Milani. 2003. Myasthenia Gravis and Related Disorders. Myasthenia Gravis and Related Disorders 53 91 .
Donald B Sanders. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Natarajan Venkatesh, Sin-Heyog Im, Moshe Balass, Sara Fuchs & Ephraim Katchalski-Katzir. (2000) Prevention of passively transferred experimental autoimmune myasthenia gravis by a phage library-derived cyclic peptide. Proceedings of the National Academy of Sciences 97:2, pages 761-766.
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. 2000. Ion Channels and Disease. Ion Channels and Disease 419 464 .
Angela Vincent, Oliver Lily & Jackie Palace. (1999) Pathogenic autoantibodies to neuronal proteins in neurological disorders. Journal of Neuroimmunology 100:1-2, pages 169-180.
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Panayota Tsantili, Socrates J. Tzartos & Avgi Mamalaki. (1999) High affinity single-chain Fv antibody fragments protecting the human nicotinic acetylcholine receptor. Journal of Neuroimmunology 94:1-2, pages 15-27.
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W.-Z. Wang, S. Fredrikson, J. Qiao, P.-O. Osterman & H. Link. (1998) The B-cell repertoire in myasthenia gravis includes all four acetylcholine receptor subunits. Acta Neurologica Scandinavica 98:6, pages 422-426.
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A Hoedemaekers, J.-L Bessereau, Y Graus, T Guyon, J.-P Changeux, S Berrih-Aknin, P van Breda Vriesman & Marc H De Baets. (1998) Role of the target organ in determining susceptibility to experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 89:1-2, pages 131-141.
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Socrates J. Tzartos, Tom Barkas, M. Thong Cung, Avgi Mamalaki, Michel Marraud, Piotr Orlewski, Danai Papanastasiou, Constantinos Sakarellos, Maria Sakarellos‐Daitsiotis, Panayota Tsantili & Vassilios Tsikaris. (2006) Anatomy of the antigenic structure of a large memberane autoantigen, the muscle‐type nicotinic acetylcholine receptor. Immunological Reviews 163:1, pages 89-120.
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ANGELA VINCENT, LESLIE JACOBSON, PAUL PLESTED, AGATA POLIZZI, TERESA TANG, SIETSKE RIEMERSMA, CLAIRE NEWLAND, SARA GHORAZIAN, JEREMY FARRAR, CAL MACLENAN, NICHOLAS WILLCOX, DAVID BEESON & JOHN NEWSDOM‐DAVIS. (2006) Antibodies Affecting Ion Channel Function in Acquired Neuromyotonia, in Seropositive and Seronegative Myasthenia Gravis, and in Antibody‐mediated Arthrogryposis Multiplex Congenita. Annals of the New York Academy of Sciences 841:1, pages 482-496.
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FRÉDÉRIC ANDRÉ, ANDRÉ VICHERAT, GUY BOUSSARD, ANDRÉ AUBRY & MICHEL MARRAUD. (2009) Aza‐peptides. III. Experimental structural analysis of aza‐alanme and aza‐asparagine‐containing peptides. The Journal of Peptide Research 50:5, pages 372-381.
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C. MacLennan, D. Beeson, A.‐M. Buijs, A. Vincent & J. Newsom‐Davis. (2004) Acetylcholine receptor expression in human extraocular muscles and their susceptibility to myasthenia gravis. Annals of Neurology 41:4, pages 423-431.
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Angela Vincent. 1997. The Synapse: In Development, Health, and Disease. The Synapse: In Development, Health, and Disease 315 349 .
Angela Vincent, Nick Willcox, Ioannis Roxanis, John Newsom-Davis, Cal McLennan & David Beeson. 1997. Epithelial Tumors of the Thymus. Epithelial Tumors of the Thymus 195 204 .
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Frédéric André, Michel Marraud, Guy Boussard, Claude Didierjean & André Aubry. (1996) Synthesis and structure of AzAsx-Pro-containing Aza-peptides. Tetrahedron Letters 37:2, pages 183-186.
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Jon Lindstrom. 1996. Ion Channels. Ion Channels 377 450 .
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Ricardo A. Maselli. (1994) Pathophysiology of Myasthenia Gravis and Lambert-Eaton Syndrome. Neurologic Clinics 12:2, pages 285-304.
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Angela Vincent, Leslie Jacobson & Paul Shillito. (1994) Response to human acetylcholine receptor α138–199: determinant spreading initiates autoimmunity to self-antigen in rabbits. Immunology Letters 39:3, pages 269-275.
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Yvo M.F. Graus & Marc H. De Baets. (1994) Molecular and structural characterization of anti-acetylcholine receptor antibodies in experimental autoimmune myasthenia gravis. Advances in Neuroimmunology 4:4, pages 457-474.
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Z.-Y. Wang, H. Link, J. Qiao, T. Olsson & W.-X. Huang. (1993) B cell autoimmunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 45:1-2, pages 103-112.
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Z.‐Y. WANG, H. LINK & W.‐X. HUANG. (2006) T‐Cell Immunity to Acetylcholine Receptor and its Subunits in Lewis Rats over the Course of Experimental Autoimmune Myasthenia Gravis. Scandinavian Journal of Immunology 37:5, pages 615-622.
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Yvo M.F. Graus, Jan J.G.M. Verschuuren, Nicolaas A. Bos, Peter J.C. van Breda Vriesman & Marc H. De Baets. (1993) VH gene family utilization of anti-acetylcholine receptor antibodies in experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 43:1-2, pages 113-124.
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Ina L. Urbatsch, Raimund K. M. Sterz, Klaus Peper & Wolfgang E. Trommer. (2005) Antigen‐specific therapy of experimental myasthenia gravis with acetylcholine receptor‐gelonin conjugates in vivo. European Journal of Immunology 23:3, pages 776-779.
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Heleni Loutrari, Socrates J. Tzartos & Toni Claudio. (2005) Use of Torpedo ‐mouse hybrid acetylcholine receptors reveals immunodominance of the α subunit in myasthenia gravis antisera . European Journal of Immunology 22:11, pages 2949-2956.
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Heleni Loutrari, Anna Kokla & Socrates J. Tzartos. (2005) Passive transfer of experimental myasthenia gravis via antigenic modulation of acetylcholine receptor. European Journal of Immunology 22:9, pages 2449-2452.
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John Newsom-Davis & Angela Vincent. (1991) Antibody-mediated neurological disease. Current Opinion in Neurobiology 1:3, pages 430-435.
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