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Original Article

The Main Immunogenic Region of the Acetylcholine Receptor. Structure and Role in Myasthenia Gravis

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Pages 259-270 | Received 09 Feb 1990, Accepted 28 Aug 1990, Published online: 07 Jul 2009

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Jackie Palace, Angela Vincent, David Beeson & John Newsom-Davis. (1994) Immunogenicity of Human Recombinant Acetylcholine Receptor α Subunit: Cytoplasmic Epitopes Dominate the Antibody Response in four Mouse Strains. Autoimmunity 18:2, pages 113-119.
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Articles from other publishers (40)

Hiroaki Yoshikawa. (2022) Autoimmunity to acetylcholine receptor channels. Neurology and Clinical Neuroscience.
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Manqiqige Su, Chongbo Zhao & Sushan Luo. (2022) Therapeutic potential of chimeric antigen receptor based therapies in autoimmune diseases. Autoimmunity Reviews 21:1, pages 102931.
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Athanasios Niarchos, Marios Zouridakis, Vassilis Douris, Assimina Georgostathi, Dimitra Kalamida, Alexandros Sotiriadis, Konstantinos Poulas, Kostas Iatrou & Socrates J. Tzartos. (2013) Expression of a Highly Antigenic and Native-Like Folded Extracellular Domain of the Human α1 Subunit of Muscle Nicotinic Acetylcholine Receptor, Suitable for Use in Antigen Specific Therapies for Myasthenia Gravis. PLoS ONE 8:12, pages e84791.
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Lin Chen. (2010) In pursuit of the high-resolution structure of nicotinic acetylcholine receptors. The Journal of Physiology 588:4, pages 557-564.
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Erdem Tüzün & Premkumar Christadoss. (2006) Unraveling myasthenia gravis immunopathogenesis using animal models. Drug Discovery Today: Disease Models 3:1, pages 15-20.
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Evdokia Protopapadakis, Anna Kokla, Socrates J. Tzartos & Avgi Mamalaki. (2005) Isolation and characterization of human anti-acetylcholine receptor monoclonal antibodies from transgenic mice expressing human immunoglobulin loci. European Journal of Immunology 35:6, pages 1960-1968.
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IRENE P STAFFORD & GARY A DILDY. (2005) Myasthenia Gravis and Pregnancy. Clinical Obstetrics and Gynecology 48:1, pages 48-56.
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Tali Feferman, Sin-Hyeog Im, Sara Fuchs & Miriam C Souroujon. (2003) Breakage of tolerance to hidden cytoplasmic epitopes of the acetylcholine receptor in experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 140:1-2, pages 153-158.
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Bianca M. Conti-Fine, Brenda Diethelm-Okita, Norma Ostlie, Wei Wang & Monica Milani. 2003. Myasthenia Gravis and Related Disorders. Myasthenia Gravis and Related Disorders 53 91 .
Donald B Sanders. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Natarajan Venkatesh, Sin-Heyog Im, Moshe Balass, Sara Fuchs & Ephraim Katchalski-Katzir. (2000) Prevention of passively transferred experimental autoimmune myasthenia gravis by a phage library-derived cyclic peptide. Proceedings of the National Academy of Sciences 97:2, pages 761-766.
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. 2000. Ion Channels and Disease. Ion Channels and Disease 419 464 .
Angela Vincent, Oliver Lily & Jackie Palace. (1999) Pathogenic autoantibodies to neuronal proteins in neurological disorders. Journal of Neuroimmunology 100:1-2, pages 169-180.
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Panayota Tsantili, Socrates J. Tzartos & Avgi Mamalaki. (1999) High affinity single-chain Fv antibody fragments protecting the human nicotinic acetylcholine receptor. Journal of Neuroimmunology 94:1-2, pages 15-27.
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W.-Z. Wang, S. Fredrikson, J. Qiao, P.-O. Osterman & H. Link. (1998) The B-cell repertoire in myasthenia gravis includes all four acetylcholine receptor subunits. Acta Neurologica Scandinavica 98:6, pages 422-426.
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A Hoedemaekers, J.-L Bessereau, Y Graus, T Guyon, J.-P Changeux, S Berrih-Aknin, P van Breda Vriesman & Marc H De Baets. (1998) Role of the target organ in determining susceptibility to experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 89:1-2, pages 131-141.
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Socrates J. Tzartos, Tom Barkas, M. Thong Cung, Avgi Mamalaki, Michel Marraud, Piotr Orlewski, Danai Papanastasiou, Constantinos Sakarellos, Maria Sakarellos‐Daitsiotis, Panayota Tsantili & Vassilios Tsikaris. (2006) Anatomy of the antigenic structure of a large memberane autoantigen, the muscle‐type nicotinic acetylcholine receptor. Immunological Reviews 163:1, pages 89-120.
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ANGELA VINCENT, LESLIE JACOBSON, PAUL PLESTED, AGATA POLIZZI, TERESA TANG, SIETSKE RIEMERSMA, CLAIRE NEWLAND, SARA GHORAZIAN, JEREMY FARRAR, CAL MACLENAN, NICHOLAS WILLCOX, DAVID BEESON & JOHN NEWSDOM-DAVIS. (1998) Antibodies Affecting Ion Channel Function in Acquired Neuromyotonia, in Seropositive and Seronegative Myasthenia Gravis, and in Antibody-mediated Arthrogryposis Multiplex Congenita. Annals of the New York Academy of Sciences 841:1 MYASTHENIA GR, pages 482-496.
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FRÉDÉRIC ANDRÉ, ANDRÉ VICHERAT, GUY BOUSSARD, ANDRÉ AUBRY & MICHEL MARRAUD. (2009) Aza‐peptides. III. Experimental structural analysis of aza‐alanme and aza‐asparagine‐containing peptides. The Journal of Peptide Research 50:5, pages 372-381.
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C. MacLennan, D. Beeson, A.‐M. Buijs, A. Vincent & J. Newsom‐Davis. (2004) Acetylcholine receptor expression in human extraocular muscles and their susceptibility to myasthenia gravis. Annals of Neurology 41:4, pages 423-431.
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Angela Vincent. 1997. The Synapse: In Development, Health, and Disease. The Synapse: In Development, Health, and Disease 315 349 .
Angela Vincent, Nick Willcox, Ioannis Roxanis, John Newsom-Davis, Cal McLennan & David Beeson. 1997. Epithelial Tumors of the Thymus. Epithelial Tumors of the Thymus 195 204 .
Ricard Cervera & Yehuda Shoenfeld. 1996. Autoantibodies. Autoantibodies 607 617 .
Frédéric André, Michel Marraud, Guy Boussard, Claude Didierjean & André Aubry. (1996) Synthesis and structure of AzAsx-Pro-containing Aza-peptides. Tetrahedron Letters 37:2, pages 183-186.
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Jon Lindstrom. 1996. Ion Channels. Ion Channels 377 450 .
D. Limal, V. Grand, R. Vanderesse, M. Marraud & A. Aubry. 1995. Peptides 1994. Peptides 1994 694 695 .
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Tiina P. Iismaa, Trevor J. Biden & John ShineTiina P. Iismaa, Trevor J. Biden & John Shine. 1995. G Protein-Coupled Receptors. G Protein-Coupled Receptors 135 169 .
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Ricardo A. Maselli. (1994) Pathophysiology of Myasthenia Gravis and Lambert-Eaton Syndrome. Neurologic Clinics 12:2, pages 285-304.
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Angela Vincent, Leslie Jacobson & Paul Shillito. (1994) Response to human acetylcholine receptor α138–199: determinant spreading initiates autoimmunity to self-antigen in rabbits. Immunology Letters 39:3, pages 269-275.
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Angela Vincent. 1994. Autoimmune Disease Models. Autoimmune Disease Models 83 106 .
Yvo M.F. Graus & Marc H. De Baets. (1994) Molecular and structural characterization of anti-acetylcholine receptor antibodies in experimental autoimmune myasthenia gravis. Advances in Neuroimmunology 4:4, pages 457-474.
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Z.-Y. Wang, H. Link, J. Qiao, T. Olsson & W.-X. Huang. (1993) B cell autoimmunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 45:1-2, pages 103-112.
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Z.‐Y. WANG, H. LINK & W.‐X. HUANG. (2006) T‐Cell Immunity to Acetylcholine Receptor and its Subunits in Lewis Rats over the Course of Experimental Autoimmune Myasthenia Gravis. Scandinavian Journal of Immunology 37:5, pages 615-622.
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Yvo M.F. Graus, Jan J.G.M. Verschuuren, Nicolaas A. Bos, Peter J.C. van Breda Vriesman & Marc H. De Baets. (1993) VH gene family utilization of anti-acetylcholine receptor antibodies in experimental autoimmune myasthenia gravis. Journal of Neuroimmunology 43:1-2, pages 113-124.
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Ina L. Urbatsch, Raimund K. M. Sterz, Klaus Peper & Wolfgang E. Trommer. (2005) Antigen‐specific therapy of experimental myasthenia gravis with acetylcholine receptor‐gelonin conjugates in vivo. European Journal of Immunology 23:3, pages 776-779.
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Heleni Loutrari, Socrates J. Tzartos & Toni Claudio. (2005) Use of Torpedo ‐mouse hybrid acetylcholine receptors reveals immunodominance of the α subunit in myasthenia gravis antisera . European Journal of Immunology 22:11, pages 2949-2956.
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Heleni Loutrari, Anna Kokla & Socrates J. Tzartos. (2005) Passive transfer of experimental myasthenia gravis via antigenic modulation of acetylcholine receptor. European Journal of Immunology 22:9, pages 2449-2452.
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John Newsom-Davis & Angela Vincent. (1991) Antibody-mediated neurological disease. Current Opinion in Neurobiology 1:3, pages 430-435.
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