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Autoimmunity Volume 15, 1993 - Issue 2
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Original Article

Insulin-Dependent Diabetes in the Nod Mouse Model II. β Cell Destruction in Autoimmune Diabetes is a TH2 and not A TH1 Mediated Event

Jeffrey T. Anderson Divisions of Immunobiology and Clinical Chemistry, Department of Pathology & Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
Janet G. Cornelius Divisions of Immunobiology and Clinical Chemistry, Department of Pathology & Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
Alyssa J. Jarpe Divisions of Immunobiology and Clinical Chemistry, Department of Pathology & Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
,
William E. Winter Divisions of Immunobiology and Clinical Chemistry, Department of Pathology & Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
&
Ammon B. Peck Divisions of Immunobiology and Clinical Chemistry, Department of Pathology & Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, 32610, USA
Pages 113-122 | Received 09 Apr 1993, Published online: 07 Jul 2009

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P. E. Beales, R. Liddf, J. Endl, R. Kientsch-Engel & P. Pozzilli. (2000) Intradermal Administration of GAD & Evaluation of Diabetes Incidence in Mice: Possible Relevance for Skin Tests in Humans. Autoimmunity 32:2, pages 109-113.
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Christopher P. Robinson, Janet Cornelius, Denise E. Bounous, Hideo Yamamoto, Michael G. Humphreys-Beher & Ammon B. Peck. (1998) Characterization of the Changing Lymphocyte Populations and Cytokine Expression in the Exocrine Tissues of Autoimmune Nod Mice. Autoimmunity 27:1, pages 29-44.
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J. Kovarik, B. E. Faulkner-Jones, M. Koulmanda & T. E. Mandel. (1997) Cytokines and Autoimmune β Cell Destruction in NOD Mouse Fetal Pancreas Isografts in. Autoimmunity 26:4, pages 245-252.
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Vijayakumar K. Ramiya, Xiao-Zhou Shang, Clive H. Wasserfall & Noel K. Maclaren. (1997) Effect of Oral and Intravenous Insulin and Glutamic Acid Decarboxylase in NOD Mice. Autoimmunity 26:3, pages 139-151.
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Beverly E. Faulkner-Jones, Majella Dempsey-Collier, Thomas E. Mandel & Leonard C. Harrison. (1996) Both TH1 and TH2 Cytokine mRNAs are Expressed in the NOD Mouse Pancreas in vivo. Autoimmunity 23:2, pages 99-110.
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Luciano Adorini, Jean-Charles Guery & Sylvie Trembleau. (1996) Manipulation of the Th1/Th2 Cell Balance: An Approach to Treat Human Autoimmune Diseases?. Autoimmunity 23:1, pages 53-68.
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Richard B. Pearce, Bent Formby, Kieran Healy & Charles M. Peterson. (1995) Association of an Androgen-Responsive T Cell Phenotype with Murine Diabetes and Idd2. Autoimmunity 20:4, pages 247-258.
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Susan Wong, Li Wen, Martin Hibberd, Ann Millward & Andrew Demaine. (1994) Analysis of the Peripheral T-Cell Receptor VP Repertoire in Newly Diagnosed Patients with Type I Diabetes. Autoimmunity 18:1, pages 77-83.
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Martin G. Scherm, Verena B. Ott & Carolin Daniel. (2016) Follicular Helper T Cells in Autoimmunity. Current Diabetes Reports 16:8.
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Hajar Vaseghi & Zohreh Jadali. (2016) Th1/Th2 cytokines in Type 1 diabetes: Relation to duration of disease and gender. Indian Journal of Endocrinology and Metabolism 20:3, pages 312.
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L S K Walker & M von Herrath. (2016) CD4 T cell differentiation in type 1 diabetes. Clinical and Experimental Immunology 183:1, pages 16-29.
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Rupert Kenefeck, Chun Jing Wang, Tauseef Kapadi, Lukasz Wardzinski, Kesley Attridge, Louise E. Clough, Frank Heuts, Alexandros Kogimtzis, Sapna Patel, Miranda Rosenthal, Masahiro Ono, David M. Sansom, Parth Narendran & Lucy S.K. Walker. (2014) Follicular helper T cell signature in type 1 diabetes. Journal of Clinical Investigation 125:1, pages 292-303.
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Tom L. Van Belle, Philippe P. Pagni, Jeanette Liao, Sowbarnika Sachithanantham, Amy Dave, Amira Bel Hani, Yulia Manenkova, Natalie Amirian, Cheng Yang, Bret Morin, Haiqing Zhang, Iain L. Campbell & Matthias G. von Herrath. (2014) Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes. Journal of Autoimmunity 55, pages 24-32.
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Kwong Tai ChengIlias Alevizos, Xibao LiuWiliam D. SwaimHongen YinStefan FeskeMasatsugu Oh-hora & Indu S. Ambudkar. (2012) STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjögren's syndrome. Proceedings of the National Academy of Sciences 109:36, pages 14544-14549.
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Tejas Patel, Vasu Patel, Rajvir Singh & Sundararajan Jayaraman. (2011) Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. Immunology & Cell Biology 89:5, pages 640-649.
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Nicolas Delaleu, Cuong Q Nguyen, Ammon B Peck & Roland Jonsson. (2011) Sjögren's syndrome: studying the disease in mice. Arthritis Research & Therapy 13:3, pages 217.
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Ole P. Kristiansen & Thomas Mandrup-Poulsen. (2005) Interleukin-6 and Diabetes. Diabetes 54:suppl_2, pages S114-S124.
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Jung-Tung Hung, Jen-Hsiang Liao, Yu-Chung Lin, Hsiu-Ying Chang, Shu-Fen Wu, Tsung-Hsien Chang, John T. Kung, Shie-Liang Hsieh, Hugh McDevitt & Huey-Kang Sytwu. (2005) Immunopathogenic role of TH1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. Journal of Autoimmunity 25:3, pages 181-192.
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Bart O. Roep, Mark Atkinson & Matthias von Herrath. (2004) Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nature Reviews Immunology 4:12, pages 989-997.
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T C MARTINS & A P ÁGUAS. (1999) Mechanisms of Mycobacterium avium -induced resistance against insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice: role of Fas and Th1 cells . Clinical and Experimental Immunology 115:2, pages 248-254.
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Vijayakumar K. Ramiya, Michael Maraist, Karl E. Arfors, Desmond A. Schatz, Ammon B. Peck & Janet G. Cornelius. (2000) Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nature Medicine 6:3, pages 278-282.
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H. Hirai, Y. Kaino, T. Ito & K. Kida. (2000) Analysis of Cytokine mRNA Expression in Pancreatic Islets of Nonobese Diabetic Mice. Journal of Pediatric Endocrinology and Metabolism 13:1.
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W. Scott Gallichan, Balaji Balasa, Joanna D. Davies & Nora Sarvetnick. (1999) Pancreatic IL-4 Expression Results in Islet-Reactive Th2 Cells That Inhibit Diabetogenic Lymphocytes in the Nonobese Diabetic Mouse. The Journal of Immunology 163:3, pages 1696-1703.
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SHIZUKA IIDA, AMMON B. PECK, JOANNE JOHNSON-TARDIEU, MANABU MORIYAMA, PATRICIA A. GLENTON, KAREN J. BYER & SAEED R. KHAN. (1999) Temporal Changes in mRNA Expression for Bikunin in the Kidneys of Rats during Calcium Oxalate Nephrolithiasis. Journal of the American Society of Nephrology 10:5, pages 986-996.
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Wassim Y. Almawi, Hala Tamim & Sami T. Azar. (1999) T Helper Type 1 and 2 Cytokines Mediate the Onset and Progression of Type I (Insulin-Dependent) Diabetes. The Journal of Clinical Endocrinology & Metabolism 84:5, pages 1497-1502.
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Sami T. Azar, Hala Tamim, Hayfa N. Beyhum, M. Zouhair HabbalWassim Y. Almawi. (1999) Type I (Insulin-Dependent) Diabetes Is a Th1- and Th2-Mediated Autoimmune Disease. Clinical Diagnostic Laboratory Immunology 6:3, pages 306-310.
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HARTEMANN, RICHARD & BOITARD. (1999) Absence of significant Th2 response in diabetes-prone non-obese diabetic (NOD) mice. Clinical and Experimental Immunology 116:2, pages 225-230.
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EVA STRANDELL, ANNE KAAS, MARIE-LOUISE HARTOFT-NIELSEN, TROELS BOCK, KARSTEN BUSCHARD & KLAUS BENDTZEN. (1999) Cytokine production in NOD mice on prophylactic insulin therapy. APMIS 107:1-6, pages 413-419.
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Peter I Karachunski, Norma S Ostlie, David K Okita & Bianca M Conti-Fine. (1999) Interleukin-4 deficiency facilitates development of experimental myasthenia gravis and precludes its prevention by nasal administration of CD4+ epitope sequences of the acetylcholine receptor. Journal of Neuroimmunology 95:1-2, pages 73-84.
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D.W.R. Gray. (1999) Type 1 diabetes: the facts fit a deficient inhibitory signal given by MHC Class II. Diabetes/Metabolism Research and Reviews 15:1, pages 29-41.
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Gianpaolo Papaccio, Bruno De Luca & Francesco Aurelio Pisanti. (1998) Macrophages and antioxidant status in the NOD mouse pancreas. Journal of Cellular Biochemistry 71:4, pages 479-490.
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W. Scott Gallichan, Tal Kafri, Troy Krahl, Inder M. Verma & Nora Sarvetnick. (1998) Lentivirus-Mediated Transduction of Islet Grafts with Interleukin 4 Results in Sustained Gene Expression and Protection from Insulitis. Human Gene Therapy 9:18, pages 2717-2726.
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Philip E. Beales, Roberto Liddi, Angela E. Giorgini, Alberto Signore, Enrica Procaccini, Kenneth Batchelor & Paolo Pozzilli. (1998) Troglitazone prevents insulin dependent diabetes in the non-obese diabetic mouse. European Journal of Pharmacology 357:2-3, pages 221-225.
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