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Autoimmunity Volume 14, 1993 - Issue 1
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Original Article

Production and Characterisation of a Human Monoclonal Thyroid Peroxidase Autoantibody

M. Horimoto Endocrine Immunology Unit, 7th floor Medicine, University of Wales College of Medicine, Cardiff, CF4 4XN, UK
,
V. S. Petersen RSR Ltd., Cardiff, CF4 4XN, UK
,
C. A. S. Pgg Department of Surgery, University of Nottingham, NG7 2UH, UK
,
N. Fukuma Endocrine Immunology Unit, 7th floor Medicine, University of Wales College of Medicine, Cardiff, CF4 4XN, UK
,
N. Wakabayashi Endocrine Immunology Unit, 7th floor Medicine, University of Wales College of Medicine, Cardiff, CF4 4XN, UK
,
Y. Kiso Endocrine Immunology Unit, 7th floor Medicine, University of Wales College of Medicine, Cardiff, CF4 4XN, UK
,
J. Furmaniak Endocrine Immunology Unit, 7th floor Medicine, University of Wales College of Medicine, Cardiff, CF4 4XN, UK
&
B. Rees Smith Endocrine Immunology Unit, 7th floor Medicine, University of Wales College of Medicine, Cardiff, CF4 4XN, UK
 show all
Pages 1-7 | Received 27 May 1992, Accepted 21 Jul 1992, Published online: 07 Jul 2009

Citations (22)

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Read on this site (2)

F. Grennan Jones, K. Ziemnicka, J. Sanders, A. Wolstenholme, R. Fiera, J. Furmaniak & B. Rees Smith. (1999) Analysis of Autoantibody Epitopes on Human Thyroid Peroxidase. Autoimmunity 30:3, pages 157-169.
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M. J. Hexham, J. I. Partridge, J. Furmaniak, B. V. Petersen, C. J. Colls, C. Pegg, Rees B. Smith & R. D. Burton. (1994) Cloning and Characterisation of TPO Autoantibodies Using Combinatorial Phage Display Libraries. Autoimmunity 17:3, pages 167-179.
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Articles from other publishers (20)

J. Furmaniak, J. Sanders, R. Núñez Miguel & B. Rees Smith. (2015) Mechanisms of Action of TSHR Autoantibodies. Hormone and Metabolic Research 47:10, pages 735-752.
Crossref
S M MCLACHLAN & B RAPOPORT. (1995) Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response. Clinical and Experimental Immunology 101:2, pages 200-206.
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Jadwiga Furmaniak, Jane Sanders & Bernard Rees Smith. (2012) Blocking type TSH receptor antibodies. Autoimmunity Highlights 4:1, pages 11-26.
Crossref
Jadwiga Furmaniak, Jane Sanders, Stuart Young, Katarzyna Kabelis, Paul Sanders, Michele Evans, Jill Clark, Jane Wilmot & Bernard Rees Smith. (2011) In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70). Autoimmunity Highlights 3:1, pages 19-25.
Crossref
Sylvie Peraldi-Roux. 2012. Antibody Engineering. Antibody Engineering 73 83 .
Jane Sanders, Ricardo Núñez Miguel, Jadwiga Furmaniak & Bernard Rees Smith. 2010. Constitutive Activity in Receptors and Other Proteins, Part B. Constitutive Activity in Receptors and Other Proteins, Part B 393 420 .
Jane SandersMichele EvansCorrado BetterlePaul SandersAnshu BhardwajaStuart YoungEmma RobertsJane WilmotTonya RichardsAngela KiddieKasemsri SmallHayley PlattSara SummerhayesRebecca HarrisMagnus ReeveGraziella CocoRenato ZanchettaShu ChenJadwiga FurmaniakBernard Rees Smith. (2008) A Human Monoclonal Autoantibody to the Thyrotropin Receptor with Thyroid-Stimulating Blocking Activity. Thyroid 18:7, pages 735-746.
Crossref
Sandra M. McLachlanBasil Rapoport. (2007) Thyroid Peroxidase as an Autoantigen. Thyroid 17:10, pages 939-948.
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Peter BurneSarah MitchellBernard Rees Smith. (2005) Point-of-Care Assays for Autoantibodies to Thyroid Peroxidase and to Thyroglobulin. Thyroid 15:9, pages 1005-1010.
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J. SandersJ. JeffreysH. DepraetereM. EvansT. RichardsA. KiddieK. BreretonL.D.K.E. PremawardhanaD.Y. ChirgadzeR. Núñez MiguelT.L. BlundellJ. FurmaniakB. Rees Smith. (2004) Characteristics of a Human Monoclonal Autoantibody to the Thyrotropin Receptor: Sequence Structure and Function. Thyroid 14:8, pages 560-570.
Crossref
Francesco Latrofa, Pavel Pichurin, Jin Guo, Basil Rapoport & Sandra M. McLachlan. (2003) Thyroglobulin-Thyroperoxidase Autoantibodies Are Polyreactive, Not Bispecific: Analysis Using Human Monoclonal Autoantibodies. The Journal of Clinical Endocrinology & Metabolism 88:1, pages 371-378.
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E. HendryG. Taylor, F. Grennan-Jones, A. Sullivan, N. Liddy, J. Godfrey, N. Hayakawa, M. Powell, J. Sanders, J. FurmaniakB. Rees Smith. (2001) X-Ray Crystal Structure of a Monoclonal Antibody That Binds to a Major Autoantigenic Epitope on Thyroid Peroxidase. Thyroid 11:12, pages 1091-1099.
Crossref
P. Gut, F. Grennan Jones, A. Sullivan, K. Zlemnicka, S. Smith, D. Jaskólski, J. Furmaniak & B. Rees Smith. (2000) Recombinant Human Thyroid Peroxidase Produced in Insect Cells has Similar Properties to Native Human Thyroid Peroxidase. Thyroid 10:7, pages 543-550.
Crossref
Nicolas Chapal, Sylvie Peraldi-Roux, Damien Bresson, Martine Pugniere, Jean-Claude Mani, Claude Granier, Line Baldet, Bernard Guerrier, Bernard Pau & Majida Bouanani. (2000) Human Anti-Thyroid Peroxidase Single-Chain Fragment Variable of Ig Isolated from a Combinatorial Library Assembled In-Cell: Insights into the In Vivo Situation. The Journal of Immunology 164:8, pages 4162-4169.
Crossref
Jadwiga Furmaniak, Jane Sanders & Bernard Rees Smith. 1999. Autoimmune Endocrinopathies. Autoimmune Endocrinopathies 183 216 .
Richard Mclntosh, Philip Watson & Anthony Weetman. (1998) Somatic hypermutation in antoimmune thyroid disease. Immunological Reviews 162:1, pages 219-231.
Crossref
Richard S. McIntoshM. Suhail AsgharE. Helen KempPhilip F. WatsonAndrzej GardasJ. Paul Banga & Anthony P. Weetman. (1997) Analysis of Immunoglobulin Gκ Antithyroid Peroxidase Antibodies from Different Tissues in Hashimoto’s Thyroiditis1. The Journal of Clinical Endocrinology & Metabolism 82:11, pages 3818-3825.
Crossref
Jane Sanders, Yasuo Oda, Sara-Anne Roberts, Masayuki Maruyama, Jadwiga Furmaniak & Bernard Rees Smith. (1997) Understanding the thyrotropin receptor function—structure relationship. Baillière's Clinical Endocrinology and Metabolism 11:3, pages 451-479.
Crossref
R.S. McINTOSH & A.P. WEETMAN. (1997) Molecular Analysis of the Antibody Response to Thyroglobulin and Thyroid Peroxidase. Thyroid 7:3, pages 471-487.
Crossref
Basil Rapoport, Stefano Portolano & Sandra M. McLachlan. (1995) Combinatorial libraries: new insights into human organ-specific autoantibodies. Immunology Today 16:1, pages 43-49.
Crossref

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