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Original Article

Aminoguanidine, An Inhibitor of Nitric Oxide Formation, Fails to Protect Against Insulitis and Hyperglycemia Induced by Multiple Low Dose Streptozotocin Injections in Mice

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Pages 311-314 | Received 23 Nov 1992, Accepted 29 Apr 1993, Published online: 07 Jul 2009

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Stellan Sandler$suffix/text()$suffix/text(), Annika K. Andersson, Andreea Barbu, Claes Hellerström, Maria Holstad, Ella Karlsson, Jan-Olov Sandberg, Eva Strandell, Johan Saldeen, Johnny Sternesjö, Linda Tillmar, Decio L. Eizirik, Malin Flodström & Nils Welsh. (2000) Novel Experimental Strategies to Prevent the Development of Type 1 Diabetes Mellitus. Upsala Journal of Medical Sciences 105:2, pages 17-34.
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Gianpaolo Papaccio, Michael Vg Latronico, Francesco Aurelio Pisanti, Konrad Federlin & Thomas Linn. (1998) Adhesion Molecules and Microvascular Changes in the Nonobese Diabetic (NOD) Mouse Pancreas. An NO-Inhibitor (L-Name) is Unable to Block Adhesion Inflammation-Induced Activation. Autoimmunity 27:2, pages 65-77.
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Stellan Sandier & Maria Holstad. (1995) Inhibition of Nitric Oxide Formation and Prevention of Type 1 Diabetes. Response from the Authors. Autoimmunity 20:1, pages 71-71.
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Gianpaolo Papaccio. (1995) Inhibition of Nitric Oxide Formation and Prevention of Type 1 Diabetes. Autoimmunity 20:1, pages 69-69.
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Articles from other publishers (22)

S. Hässler, L. Peltonen, S. Sandler & O. Winqvist. (2008) Aire Deficiency Causes Increased Susceptibility to Streptozotocin-induced Murine Type 1 Diabetes. Scandinavian Journal of Immunology 67:6, pages 569-580.
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Kyoichi Fukuda, Greg H Tesch, Felicia Y Yap, Josephine M Forbes, Richard A Flavell, Roger J Davis & David J Nikolic-Paterson. (2008) MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model. Laboratory Investigation 88:4, pages 398-407.
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Daisuke Fukudome, Maki Matsuda, Toshiyuki Kawasaki, Yukio Ago & Toshio Matsuda. (2008) The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice. European Journal of Pharmacology 583:1, pages 164-169.
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Zecharia Madar, Shiri Kalet-Litman & Aliza H. Stark. (2005) Inducible Nitric Oxide Synthase Activity and Expression in Liver and Hepatocytes of Diabetic Rats. Pharmacology 73:2, pages 106-112.
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Annika K Andersson, Lina Thorvaldson, Carina Carlsson & Stellan Sandler. (2004) Cytokine-induced PGE2 formation is reduced from iNOS deficient murine islets. Molecular and Cellular Endocrinology 220:1-2, pages 21-29.
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Jon G. Mabley, Gary J. Southan, Andrew L. Salzman & Csaba Szabó. (2004) The Combined Inducible Nitric Oxide Synthase Inhibitor and Free Radical Scavenger Guanidinoethyldisulfide Prevents Multiple Low-Dose Streptozotocin-Induced Diabetes In Vivo and Interleukin-1β-Induced Suppression of Islet Insulin Secretion In Vitro. Pancreas 28:2, pages e39-e44.
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Olaf Morgenstern, Heike Wanka, Ilka Röser, Antje Steveling & Beate Kuttler. (2004) Synthesis, structural investigations and biological evaluation of novel hexahydropyridazine-1-carboximidamides, -carbothioamides and -carbothioimidic acid esters as inducible nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry 12:5, pages 1071-1089.
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Maria Holstad & Stellan Sandler. (2001) A Transcriptional Inhibitor of TNF-α Prevents Diabetes Induced by Multiple Low-Dose Streptozotocin Injections in Mice. Journal of Autoimmunity 16:4, pages 441-447.
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Annika K. Andersson, Malin Flodström & Stellan Sandler. (2001) Cytokine-Induced Inhibition of Insulin Release from Mouse Pancreatic β-Cells Deficient in Inducible Nitric Oxide Synthase. Biochemical and Biophysical Research Communications 281:2, pages 396-403.
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Ferdinando Nicoletti, Roberto Di Marco, Ignacio Conget, Ramon Gomis, Carl EdwardsIIIIII, Gianpaolo Papaccio, Klaus Bendtzen & Stellan Sandler. (2000) Sodium Fusidate Ameliorates the Course of Diabetes Induced in Mice by Multiple Low Doses of Streptozotocin. Journal of Autoimmunity 15:4, pages 395-405.
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Gianpaolo Papaccio, Francesco Aurelio Pisanti, Michael V.G. Latronico, Eduardo Ammendola & Michela Galdieri. (2000) Multiple low-dose and single high-dose treatments with streptozotocin do not generate nitric oxide. Journal of Cellular Biochemistry 77:1, pages 82-91.
Crossref
V. Burkart & H. Kolb. 2000. Nitric Oxide. Nitric Oxide 525 544 .
Adrian J. HobbsAnnie HiggsSalvador Moncada. (1999) INHIBITION OF NITRIC OXIDE SYNTHASE AS A POTENTIAL THERAPEUTIC TARGET. Annual Review of Pharmacology and Toxicology 39:1, pages 191-220.
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Toshinari Takamura, Ichiro Kato, Noriko Kimura, Tetsuya Nakazawa, Hideto Yonekura, Shin Takasawa & Hiroshi Okamoto. (1998) Transgenic Mice Overexpressing Type 2 Nitric-oxide Synthase in Pancreatic β Cells Develop Insulin-dependent Diabetes without Insulitis. Journal of Biological Chemistry 273:5, pages 2493-2496.
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Maria Holstad, Leif Jansson & Stellan Sandler. (1997) Inhibition of nitric oxide formation by aminoguanidine: An attempt to prevent insulin-dependent diabetes mellitus. General Pharmacology: The Vascular System 29:5, pages 697-700.
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Volker Burkart & Hubert Kolb. (1996) Macrophages in Islet Destruction in Autoimmune Diabetes Mellitus. Immunobiology 195:4-5, pages 601-613.
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Maria Holstad, Leif Jansson & Stellan Sandler. (1996) Effects of aminoguanidine on rat pancreatic islets in culture and on the pancreatic islet blood flow of anaesthetized rats. Biochemical Pharmacology 51:12, pages 1711-1717.
Crossref
Ernst Johannes Menzel & Roland Reihsner. (2016) Comparison of the Effect of Different Inhibitors on the Non-Enzymatic Glycation of Rat Tail Tendons and Bovine Serum Albumin. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 33:3, pages 241-248.
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Garry J. Southan & Csaba Szabó. (1996) Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochemical Pharmacology 51:4, pages 383-394.
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Antje Faust, Rainer Kleemann, Helga Rothe & Hubert Kolb. 1996. Lessons from Animal Diabetes VI. Lessons from Animal Diabetes VI 47 56 .
Gianpaolo Papaccio, Gabriella Chieffi Baccari, Sonia Frascatore, Stefania Sellitti & Francesco Aurelio Pisanti. (1995) The vitamin-E derivative U-83836-E in the low-dose streptozocin-treated mouse: effects on diabetes development. Diabetes Research and Clinical Practice 30:3, pages 163-171.
Crossref
M. Welsh, N. Welsh, K. Bendtzen, J. Mares, E. Strandell, C. �berg & S. Sandler. (1995) Comparison of mRNA contents of interleukin-1? and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice. Diabetologia 38:2, pages 153-160.
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