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Original Article

For Debate Nitric Oxide and Pancreatic P-Cell Destruction in Insulin Dependent Diabetes Mellitus: Don't Take no for an Answer

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Pages 285-290 | Published online: 07 Jul 2009

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Vesile Duzguner, Altug Kucukgul, Suat Erdogan, Sefa Celik & Kazim Sahin. (2008) Effect of Lycopene Administration on Plasma Glucose, Oxidative Stress and Body Weight in Streptozotocin Diabetic Rats. Journal of Applied Animal Research 33:1, pages 17-20.
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Stellan Sandier & Maria Holstad. (1995) Inhibition of Nitric Oxide Formation and Prevention of Type 1 Diabetes. Response from the Authors. Autoimmunity 20:1, pages 71-71.
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Articles from other publishers (28)

Ahmet BEYATLİ, Emine Gülçeri GÜLEÇ PEKER, Nursel GÜL & Şule Coşkun CEVHER. (2022) Morin (2′,3,4′,5,7-Pentahydroxyflavon) Antioxidant Effect in Streptozotocin-Induced Diabetic Rat Brain and Heart TissuesMorin (2′,3,4′,5,7-Pentahidroksiflavon) Streptozotosin ile İndüklenen Diyabetik Sıçan Beyin ve Kalp Dokularında Antioksidan Etkisi. Journal of Anatolian Environmental and Animal Sciences 7:3, pages 257-262.
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Anjaneyulu Kowluru. (2020) Oxidative Stress in Cytokine-Induced Dysfunction of the Pancreatic Beta Cell: Known Knowns and Known Unknowns. Metabolites 10:12, pages 480.
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Bashair M. Mussa, Ankita Srivastava, Abdul Khader Mohammed & Anthony J. M. Verberne. (2020) Nitric oxide interacts with cholinoceptors to modulate insulin secretion by pancreatic β cells. Pflügers Archiv - European Journal of Physiology 472:10, pages 1469-1480.
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Ewa Gurgul-Convey, Ilir Mehmeti, Thomas Plötz, Anne Jörns & Sigurd Lenzen. (2016) Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines. Diabetologia 59:10, pages 2125-2133.
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Dogan Orman, Nigar Vardi, Burhan Ates, Elif Taslidere & Hulya Elbe. (2015) Aminoguanidine mitigates apoptosis, testicular seminiferous tubules damage, and oxidative stress in streptozotocin-induced diabetic rats. Tissue and Cell 47:3, pages 284-290.
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Manpreet Kaur, Onkar Bedi, Shilpi Sachdeva, B. V. K. Krishna Reddy & Puneet Kumar. (2014) Rodent animal models: from mild to advanced stages of diabetic nephropathy. Inflammopharmacology 22:5, pages 279-293.
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. (2012) FEATURES. Asia-Pacific Biotech News 16:01, pages 11-28.
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Ewa Gurgul-Convey, Ilir Mehmeti, Stephan Lortz & Sigurd Lenzen. (2011) Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria. Journal of Molecular Medicine 89:8, pages 785-798.
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Dariush MokhtariAndreea BarbuIlir Mehmeti, Chantal Vercamer & Nils Welsh. (2009) Overexpression of the nuclear factor-κB subunit c-Rel protects against human islet cell death in vitro. American Journal of Physiology-Endocrinology and Metabolism 297:5, pages E1067-E1077.
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C. Holohan, E. Szegezdi, T. Ritter, T. O'Brien & A. Samali. (2008) Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X L . Journal of Cellular and Molecular Medicine 12:2, pages 591-606.
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Elena Ju. Sudnikovich, Yuri Z. Maksimchik, Svetlana V. Zabrodskaya, Valeri L. Kubyshin, Elena A. Lapshina, Maria Bryszewska, Russel J. Reiter & Ilya B. Zavodnik. (2007) Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats. European Journal of Pharmacology 569:3, pages 180-187.
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András Hrabák, Arnold Szabó, Tamás Bajor & Anna Körner. (2006) Differences in the nitric oxide metabolism in streptozotocin-treated rats and children suffering from Type 1 diabetes. Life Sciences 78:12, pages 1362-1370.
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Mamdouh M. Anwar & Abdel-Raheim M.A. Meki. (2003) Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 135:4, pages 539-547.
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Åke Sjöholm, Per-Olof Berggren & Robert V. Cooney. (2000) γ-Tocopherol Partially Protects Insulin-Secreting Cells against Functional Inhibition by Nitric Oxide. Biochemical and Biophysical Research Communications 277:2, pages 334-340.
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Gianpaolo Papaccio, Francesco Aurelio Pisanti, Michael V.G. Latronico, Eduardo Ammendola & Michela Galdieri. (2000) Multiple low-dose and single high-dose treatments with streptozotocin do not generate nitric oxide. Journal of Cellular Biochemistry 77:1, pages 82-91.
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Monique R. Heitmeier & John A. Corbett. 2000. Nitric Oxide. Nitric Oxide 785 810 .
M.F. McCarty & A.L. Russell. (1999) Niacinamide therapy for osteoarthritis – does it inhibit nitric oxide synthase induction by interleukin-1 in chondrocytes?. Medical Hypotheses 53:4, pages 350-360.
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Giatgen A. Spinas. (1999) The Dual Role of Nitric Oxide in Islet β-Cells. Physiology 14:2, pages 49-54.
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Lin Wang, Arin Bhattacharjee, Zhuang ZuoFuquan Hu, Richard E. HonkanenPer-Olof Berggren & Ming Li. (1999) A Low Voltage-Activated Ca2+ Current Mediates Cytokine-Induced Pancreatic β-Cell Death*. Endocrinology 140:3, pages 1200-1204.
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D.W.R. Gray. (1999) Type 1 diabetes: the facts fit a deficient inhibitory signal given by MHC Class II. Diabetes/Metabolism Research and Reviews 15:1, pages 29-41.
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Gianpaolo Papaccio, Bruno De Luca & Francesco Aurelio Pisanti. (1998) Macrophages and antioxidant status in the NOD mouse pancreas. Journal of Cellular Biochemistry 71:4, pages 479-490.
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Ζ. Laron. (1998) Childhood Diabetes Towards the 21st Century. Journal of Pediatric Endocrinology and Metabolism 11:3.
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Michael O. Kurrer, Syamasundar V. Pakala, Holly L. Hanson & Jonathan D. Katz. (1997) β cell apoptosis in T cell-mediated autoimmune diabetes. Proceedings of the National Academy of Sciences 94:1, pages 213-218.
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Yann A. Henry, Annie Guissani & Béatrice DucastelYann A. Henry. 1996. Nitric Oxide Research from Chemistry to Biology. Nitric Oxide Research from Chemistry to Biology 235 270 .
Csaba SzabÓ. (1996) DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite. Free Radical Biology and Medicine 21:6, pages 855-869.
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Eva Strandell, Karsten Buschard, Johan Saldeen & Nils Welsh. (1995) Interleukin-1β induces the expression of HSP70, heme oxygenase and Mn-SOD in FACS-purified rat islet β-cells, but not in α-cells. Immunology Letters 48:2, pages 145-148.
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K. Fehsel, K.-D. Kröncke & V. Kolb-Bachofen. (1995) The action of NO and its role in autoimmune diabetes mellitus. Research in Immunology 146:9, pages 711-715.
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