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Autoimmunity Volume 19, 1994 - Issue 2
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Original Article

Autoantibodies Against Gad65 Rather Than Gad67 Precede the Onset of Type 1 Diabetes

F. Luhder institute of Diabetes “Gerhardt Katsch” of the University of Greifswald, Karlsburg, Germany
,
M. Schlosser institute of Diabetes “Gerhardt Katsch” of the University of Greifswald, Karlsburg, Germany
,
L. Mauch Department of Molecular Biology, elias Entwicklungslabor, Freiburg, Germany
,
H. Haubruck Department of Molecular Biology, elias Entwicklungslabor, Freiburg, Germany
,
I. Rjasanowski Clinic of Diabetes and Metabolic Diseases, Karlsburg, Germany
,
D. Michaelis Clinic of Diabetes and Metabolic Diseases, Karlsburg, Germany
,
K-D. Kohnert institute of Diabetes “Gerhardt Katsch” of the University of Greifswald, Karlsburg, Germany
&
M. Ziegler institute of Diabetes “Gerhardt Katsch” of the University of Greifswald, Karlsburg, Germany
 show all
Pages 71-80 | Published online: 07 Jul 2009

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Marika Vianello, Marika Vianello, Giacomo Bisson, Marika Vianello, Giacomo Bisson, Marco Dal Maschio, Stefano Vassanelli, Stefano Girardi, Carla Mucignat, Kostantinos Fountzoulas & Bruno Giometto. (2008) Increased spontaneous activity of a network of hippocampal neurons in culture caused by suppression of inhibitory potentials mediated by anti-gad antibodies. Autoimmunity 41:1, pages 66-73.
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B. Zlegler, M. Strebelow, I. Rjasanowski, M. Schlosser & M. Ziegler. (1998) A Monoclonal Antibody-Based Characterization of Autoantibodies against Glutamic Acid Decarboxylase in Adults with Latent Autoimmune Diabetes. Autoimmunity 28:2, pages 61-68.
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Michael Schlosser, Jens Hahmann, Brigitte Ziegler, Petra Augstein & Manfred Ziegler. (1997) Sensitive Monoclonal Antibody-Based Sandwich Elisa for Determination of the Diabetes-Associated Autoantigen Glutamic Acid Decarboxylase GAD65. Journal of Immunoassay 18:4, pages 289-307.
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Articles from other publishers (20)

Amelia Cecchin, Claire Reynolds, Syed Ali & Pravin Hissaria. (2023) Evaluation of glutamic acid decarboxylase (GAD) 65 antibody detection methods for neurological and diabetic investigation in an Australian diagnostic laboratory. Pathology 55:4, pages 538-542.
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Nicole Hartwig Trier, Niccolo Valdarnini, Ilaria Fanelli, Paolo Rovero, Paul Robert Hansen, Claus Schafer-Nielsen, Evaldas Ciplys, Rimantas Slibinskas, Flemming Pociot, Tina Friis & Gunnar Houen. (2022) Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C. International Journal of Molecular Sciences 23:8, pages 4424.
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Francesc Graus, Albert Saiz & Josep Dalmau. (2020) GAD antibodies in neurological disorders — insights and challenges. Nature Reviews Neurology 16:7, pages 353-365.
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David J. Bylund & Robert M. Nakamura. 2011. Henry's Clinical Diagnosis and Management by Laboratory Methods. Henry's Clinical Diagnosis and Management by Laboratory Methods 1003 1020 .
Janet M. Wenzlau, Leah Sheridan & John C. Hutton. 2011. Immunoendocrinology: Scientific and Clinical Aspects. Immunoendocrinology: Scientific and Clinical Aspects 15 39 .
Janet M Wenzlau, John C Hutton & Howard W Davidson. (2008) New antigenic targets in type 1 diabetes. Current Opinion in Endocrinology, Diabetes & Obesity 15:4, pages 315-320.
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Janet M. Wenzlau, Kirstine Juhl, Liping Yu, Ong Moua, Suparna A. Sarkar, Peter Gottlieb, Marian Rewers, George S. Eisenbarth, Jan Jensen, Howard W. Davidson & John C. Hutton. (2007) The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proceedings of the National Academy of Sciences 104:43, pages 17040-17045.
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William Winter. 2006. Pediatric Endocrinology. Pediatric Endocrinology 83 99 .
MICHAEL SCHLOSSER, RALF WASSMUTH, MARTINA STREBELOW, ILONA RJASANOWSKI & MANFRED ZIEGLER. (2003) Multiple and High-Titer Single Autoantibodies in Schoolchildren Reflecting the Genetic Predisposition for Type 1 Diabetes. Annals of the New York Academy of Sciences 1005:1, pages 98-108.
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William E. Winter, Neil Harris & Desmond Schatz. (2002) Type 1 Diabetes Islet Autoantibody Markers. Diabetes Technology & Therapeutics 4:6, pages 817-839.
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William E. Winter, Neil Harris & Desmond Schatz. (2002) Immunological Markers in the Diagnosis and Prediction of Autoimmune Type 1a Diabetes. Clinical Diabetes 20:4, pages 183-191.
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M.E.R. da Silva, G. Porta, A.C. Golberg, P.L. Bittencourt, R.T. Fukui, M.R.S. Correia, I.K. Miura, R.S. Pugliese, V.L. Baggio, E.L.R. Cançado, J. Kalil, R.F. Santos, D.M. Rochal, B.L. Wajchenberg, M.J.M. Ursich & A.L. Rosenbloom. (2002) Diabetes Mellitus-Related Autoantibodies in Childhood Autoimmune Hepatitis. Journal of Pediatric Endocrinology and Metabolism 15:6.
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William E. Winter. (1999) The use of islet autoantibody markers in the prediction of autoimmune type 1 diabetes. Clinical Immunology Newsletter 19:3, pages 25-39.
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Jadwiga Furmaniak, Jane Sanders & Bernard Rees Smith. 1999. Autoimmune Endocrinopathies. Autoimmune Endocrinopathies 183 216 .
Dorlinda V. House & William E. Winter. (1997) Autoimmune Diabetes. Clinics in Laboratory Medicine 17:3, pages 499-545.
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C Tiberti, A Falorni, P Torresi, E Vecci, E Anastasi, F Dotta & U Di Mario. (1997) A new solid-phase radioimmunoassay to detect anti-GAD65 autoantibodies. Journal of Immunological Methods 207:2, pages 107-113.
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Michael Powell, Louise Prentice, Takayuki Asawa, Ryoji Kato, Joanna Sawicka, Hideaki Tanaka, Vaughan Petersen, Andrea Munkley, Sharon Morgan, Bernard Rees Smith & Jadwiga Furmaniak. (1996) Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast. Clinica Chimica Acta 256:2, pages 175-188.
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B. Ziegler, M. Schlosser, F. Lühder, M. Strebelow, P. Augstein, W. Northemann, A. C. Powers & M. Ziegler. (1996) Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and Stiff-man syndrome. Acta Diabetologica 33:3, pages 225-231.
Crossref
Petra Augstein, Michael Schlosser, Brigitte Ziegler, Jens Hahmann, Ludwig Mauch & Manfred Ziegler. (1996) Comparison of the islet cell antibody pattern of monoclonal glutamic acid decarboxylase antibodies recognizing linear and conformational epitopes. Acta Histochemica 98:2, pages 229-241.
Crossref
K. D. Kohnert, B. Hehmke, H. Keilacker, M. Ziegler, F. Emmrich, F. Laube & D. Michaelis. (1996) Antibody response to islet antigens in anti-CD4/prednisolone immune intervention of type 1 diabetes. International Journal of Clinical & Laboratory Research 26:1, pages 55-59.
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