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Original Article

Radioimmunoassay Detects the Frequent Occurrence of Autoantibodies to the Mr 65,000 Isoform of Glutamic Acid Decarboxylase in Japanese Insulin-Dependent Diabetes

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Pages 113-125 | Published online: 07 Jul 2009

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Lynn M. Bekris, Cindy Shephard, Morgan Peterson, Jana Hoehna, Brian Van Yserloo, Elizabeth Rutledge, Federico Farin, Terrance J. Kavanagh & Ake Lernmark. (2005) Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset. Autoimmunity 38:8, pages 567-575.
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Mona Landin-Olsson, Hans J. Arnqvist, Göran Blohmé, Bengt Littorin, Folke Lithner, Lennarth Nyström, Bengt Scherstéan, Göran Sundkvist, Lars Wibell, Jan Östman & Åke Lernmark. (1999) Appearance of Islet Cell Autoantibodies after Clinical Diagnosis of Diabetes Mellitus. Autoimmunity 29:1, pages 57-63.
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Articles from other publishers (41)

M Maziarz, W Hagopian, J P Palmer, C B Sanjeevi, I Kockum, N Breslow, Å Lernmark, Jinko Graham, Brad MacNeney, Hans Arnqvist, Mona Landin-Olsson, Lennarth Nyström, Lars Olof Ohlson, Jan Östman, M Aili Halmstad, LE Bååth Östersund, E Carlsson Kalmar, H Edenwall Karlskrona, G Forsander Falun, BW Granström Gällivare, I Gustavsson Skellefteå, R Hanås Uddevalla, L Hellenberg Nyköping, H Hellgren Lidköping, E Holmberg Umeå, H Hörnell Hudiksvall, Sten-A Ivarsson Malmö, C Johansson Jönköping, G Jonsell Karlstad, B Lindblad Mölndal, A Lindh Borås, J Ludvigsson Linköping, U Myrdal Västerås, J Neiderud Helsingborg, K Segnestam Eskilstuna, L Skogsberg Boden, L Strömberg Norrköping, U Ståhle Ängelholm, B Thalme Huddinge, K Tullus Danderyd, T Tuvemo Uppsala, M Wallensteen Stockholm, O Westphal Göteborg & J Åman Örebro. (2015) Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies. Genes & Immunity 16:8, pages 541-551.
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Elisa Gecchele, Stefan Schillberg, Matilde Merlin, Mario Pezzotti & Linda Avesani. (2014) A downstream process allowing the efficient isolation of a recombinant amphiphilic protein from tobacco leaves. Journal of Chromatography B 960, pages 34-42.
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Linda Avesani, Matilde Merlin, Elisa Gecchele, Stefano Capaldi, Annalisa Brozzetti, Alberto Falorni & Mario Pezzotti. (2013) Comparative analysis of different biofactories for the production of a major diabetes autoantigen. Transgenic Research 23:2, pages 281-291.
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Alberto Falorni & Viviana Minarelli. (2013) Autoanticorpi nel diabete mellitoAutoantibodies in diabetes mellitus. La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine 9:4, pages 209-217.
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David M. Tridgell, Charles Spiekerman, Richard S. Wang & Carla J. Greenbaum. (2011) Interaction of Onset and Duration of Diabetes on the Percent of GAD and IA-2 Antibody–Positive Subjects in the Type 1 Diabetes Genetics Consortium Database. Diabetes Care 34:4, pages 988-993.
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David J. Bylund & Robert M. Nakamura. 2011. Henry's Clinical Diagnosis and Management by Laboratory Methods. Henry's Clinical Diagnosis and Management by Laboratory Methods 1003 1020 .
M Maziarz, M Janer, J C Roach, W Hagopian, J P Palmer, K Deutsch, C B Sanjeevi, I Kockum, N Breslow & Å Lernmark. (2010) The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies. Genes & Immunity 11:5, pages 406-415.
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Sergueï O. Fetissov, Sophie Bensing, Jan Mulder, Erwan Le Maitre, Anna‐Lena Hulting, Tibor Harkany, Olov Ekwall, Filip Sköldberg, Eystein S. Husebye, Jaakko Perheentupa, Fredrik Rorsman, Olle Kämpe & Tomas Hökfelt. (2008) Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems. Journal of Comparative Neurology 513:1, pages 1-20.
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P. Zhou, S. Ten, S. Sinha, N. Ramchandani, M. Vogiatzi & N. Maclaren. (2008) Insulin Receptor Autoimmunity and Insulin Resistance. Journal of Pediatric Endocrinology and Metabolism 21:4.
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Raivo Uibo & Åke Lernmark. 2008. Immunopathogenesis of Type 1 Diabetes Mellitus. Immunopathogenesis of Type 1 Diabetes Mellitus 39 78 .
T Maruyama, S Oak, T R Hall, J P Banga, E Ortqvist, R A Ettinger, J Endl & C S Hampe. (2007) Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles. Clinical and Experimental Immunology 150:3, pages 416-421.
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J-H Shin, M Janer, B McNeney, S Blay, K Deutsch, C B Sanjeevi, I Kockum, Å Lernmark & J Graham. (2007) IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5. Genes & Immunity 8:6, pages 503-512.
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C S Hampe, T R Hall, Å Ågren & O Rolandsson. (2007) Longitudinal changes in epitope recognition of autoantibodies against glutamate decarboxylase 65 (GAD65Ab) in prediabetic adults developing diabetes. Clinical and Experimental Immunology 148:1, pages 72-78.
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Sophie BensingSergueï O. FetissovJan MulderJaakko PerheentupaJan GustafssonEystein S. HusebyeMikael OscarsonOlov Ekwall, Patricia A. Crock, Tomas HökfeltAnna-Lena HultingOlle Kämpe. (2007) Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1. Proceedings of the National Academy of Sciences 104:3, pages 949-954.
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M. GUPTA, J. GRAHAM, B. MCNEENY, M. ZARGHAMI, M. LANDIN-OLSSON, W. A HAGOPIAN, J. PALMER, A. LERNMARK & C. B SANJEEVI. (2006) MHC Class I Chain-Related Gene-A Is Associated with IA2 and IAA but Not GAD in Swedish Type 1 Diabetes Mellitus. Annals of the New York Academy of Sciences 1079:1, pages 229-239.
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Ilkka Vauhkonen, Leo Niskanen, Mikael Knip, Leena Moilanen Mykkänen, Steven Haffner, Matti Uusitupa & Markku Laakso. (2005) Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults. European Journal of Endocrinology 153:2, pages 265-273.
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Cheng‐Chong Chou, Kuei‐Hsiang Lin, Guan‐Ming Ke, Yi‐Ching Tung, Jeng‐Yin Cheng, Bai‐Hsiun Chen & Mei‐Chyn Chao. (2009) Comparison of Nucleotide Sequence of P2C Region in Diabetogenic and Non‐Diabetogenic Coxsackie Virus B5 Isolates. The Kaohsiung Journal of Medical Sciences 20:11, pages 525-532.
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Elisabet Agardh, Lakshmi K. Gaur, Åke Lernmark & Carl-David Agardh. (2004) HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients. Journal of Diabetes and its Complications 18:1, pages 32-36.
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Giuseppe Murdolo, D. Francisci, F. Forini, F. Baldelli, G. Angeletti, G. Stagni, F. Santeusanio, F. Calcinaro & A. Falorni. (2014) Expression of endocrine autoantibodies in chronic hepatitis C, before and after interferon-α therapy. Journal of Endocrinological Investigation 25:11, pages 938-946.
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Jinko Graham, William A. Hagopian, Ingrid Kockum, Lou Sheng Li, Carani B. Sanjeevi, Robert M. Lowe, Jonathan B. Schaefer, Marjan Zarghami, Heather L. Day, Mona Landin-Olsson, Jerry P. Palmer, Marta Janer-Villanueva, Leroy Hood, Göran Sundkvist, Åke Lernmark, Norman Breslow, Gisela Dahlquist & Göran Blohmé. (2002) Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes. Diabetes 51:5, pages 1346-1355.
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A. SHTAUVERE-BRAMEUS, W. HAGOPIAN, I. RUMBA & C. B. SANJEEVI. (2006) Antibodies to New Beta Cell Antigen ICA12 in Latvian Diabetes Patients. Annals of the New York Academy of Sciences 958:1, pages 297-304.
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A. KANUNGO, K. C. SAMAL & C. B. SANJEEVI. (2006) Molecular Mechanisms Involved in the Etiopathogenesis of Malnutrition-Modulated Diabetes Mellitus. Annals of the New York Academy of Sciences 958:1, pages 138-143.
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TETSURO KOBAYASHI, TARO MARUYAMA, AKIRA SHIMADA, AKIRA KASUGA, AZUMA KANATSUKA, IZUMI TAKEI, SHOICHIRO TANAKA & JUNICHI YOKOYAMA. (2006) Insulin Intervention to Preserve β Cells in Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitusa. Annals of the New York Academy of Sciences 958:1, pages 117-130.
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E H Kemp, D J Gawkrodger, P F Watson & A P Weetman. (1998) Autoantibodies to human melanocyte-specific protein Pmel17 in the sera of vitiligo patients: a sensitive and quantitative radioimmunoassay (RIA). Clinical and Experimental Immunology 114:3, pages 333-338.
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Bai Hsiun Chen, Shiang Bing Chung, Wen Chiang & Mei Chyn Chao. (2001) GAD65 antibody prevalence and association with thyroid antibodies, HLA-DR in Chinese children with type 1 diabetes mellitus. Diabetes Research and Clinical Practice 54:1, pages 27-32.
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Takayuki Kono, Fusanori Nishimura, Hikaru Sugimoto, Kenichi Sikata, Hirofumi Makino & Yoji Murayama. (2001) Human Fibroblasts Ubiquitously Express Glutamic Acid Decarboxylase 65 (GAD 65): Possible Effects of Connective Tissue Inflammation on GAD Antibody Titer. Journal of Periodontology 72:5, pages 598-604.
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Christiane S. Hampe, Lisa P. Hammerle, Alberto Falorni, John Robertson & Åke Lernmark. (2001) Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding. FEBS Letters 488:3, pages 185-189.
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Christiane S. Hampe, Lisa P. Hammerle, Lynn Bekris, Eva ÖrtqvistIngrid Kockum, Olov Rolandsson, Mona Landin-Olsson, Carina Törn, Bengt PerssonÅke Lernmark. (2000) Recognition of Glutamic Acid Decarboxylase (GAD) by Autoantibodies from Different GAD Antibody-Positive Phenotypes1. The Journal of Clinical Endocrinology & Metabolism 85:12, pages 4671-4679.
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Giovanni Gambelunghe, Francesca Forini, Stefano Laureti, Giuseppe Murdolo, Gianluca Toraldo, Fausto Santeusanio, Paolo Brunetti, Carani B. Sanjeevi & Alberto Falorni. (2001) Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies. Clinical Endocrinology 52:5, pages 565-573.
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