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Autoimmunity Volume 17, 1994 - Issue 3
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Original Article

Cloning and Characterisation of TPO Autoantibodies Using Combinatorial Phage Display Libraries

M. J. Hexham Krebs Institute, Department of Molecular Biology, University of Sheffield, UK
,
J. I. Partridge Krebs Institute, Department of Molecular Biology, University of Sheffield, UK
,
J. Furmaniak Endocrine Immunology Unit, Department of Medicine, University of Wales College of Medicine, Cardiff, UK
,
B. V. Petersen RSR Ltd., Cardiff, UK
,
C. J. Colls RSR Ltd., Cardiff, UK
,
C. Pegg Department of Surgery, University of Nottingham, UK
,
Rees B. Smith Endocrine Immunology Unit, Department of Medicine, University of Wales College of Medicine, Cardiff, UK
&
R. D. Burton Departments of Immunology and Molecular Biology, The Scripps Research Institute, LaJolla, USA
 show all
Pages 167-179 | Received 24 Jun 1993, Published online: 07 Jul 2009

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Sandra M. McLachlan & Basil Rapoport. (2000) Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator. International Reviews of Immunology 19:6, pages 587-618.
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Ayumu Kakinuma, Stefano Portolano, Gregorio Chazenbalk, Basil Rapoport & Sandra M. McLachlan. (1997) Insight into Screening Immunoglobulin Gene Combinatorial Libraries in a Phage Display Vector: A Tale of Two Antibodies. Autoimmunity 25:2, pages 73-84.
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Andrew JT George & Agamemnon A Epenetos. (1996) Section Review Biologicals & Immunologicals: Advances in antibody engineering. Expert Opinion on Therapeutic Patents 6:5, pages 441-456.
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Juan Carlos Jaume, Stefano Portolano, Basil Rapoport & Sandra M. Mclachlan. (1996) Influence of the Light Chain Repertoire on Immunoglobulin Genes Encoding Thyroid Autoantibody Fab from Combinatorial Libraries. Autoimmunity 24:1, pages 11-23.
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Articles from other publishers (25)

Zehua Sun, Shiqiang Lu, Zheng Yang, Jingjing Li & Mei-yun Zhang. (2017) Construction of a recombinant full-length membrane associated IgG library. Virus Research 238, pages 156-163.
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S M MCLACHLAN & B RAPOPORT. (1995) Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response. Clinical and Experimental Immunology 101:2, pages 200-206.
Crossref
Sandra M. McLachlan & Basil Rapoport. (2008) Thyroid peroxidase autoantibody epitopes revisited*. Clinical Endocrinology 69:4, pages 526-527.
Crossref
Sandra M. McLachlanBasil Rapoport. (2007) Thyroid Peroxidase as an Autoantigen. Thyroid 17:10, pages 939-948.
Crossref
S.-A. Rebuffat, D. Bresson & S. Peraldi-Roux. (2005) Les autoanticorps antithyroperoxydase : de la construction de banques combinatoires de fragments d'anticorps à la localisation de la région immunodominante de la thyroperoxydase. Immuno-analyse & Biologie Spécialisée 20:4, pages 197-204.
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M BEHRENDT, L J PARTRIDGE, B GRIFFITHS, M GOODFIELD, M SNAITH & N J LINDSEY. (2003) The role of somatic mutation in determining the affinity of anti-DNA antibodies. Clinical and Experimental Immunology 131:1, pages 182-189.
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Pavel N. Pichurin, Jin Guo, Valerie Estienne, Pierre Carayon, Jean Ruf, Basil Rapoport & Sandra M. McLachlan. (2002) Evidence that the Complement Control Protein-Epidermal Growth Factor-Like Domain of Thyroid Peroxidase Lies on the Fringe of the Immunodominant Region Recognized by Autoantibodies. Thyroid 12:12, pages 1085-1095.
Crossref
J Guo, R S Mcintosh, B Czarnocka, A P Weetman, B Rapoport & S M Mclachlan. (1998) Relationship between autoantibody epitopic recognition and immunoglobulin gene usage. Clinical and Experimental Immunology 111:2, pages 408-414.
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J GUO, Y WANG, J C JAUME, B RAPOPORT & S M MCLACHLAN. (1999) Rarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region. Clinical and Experimental Immunology 117:1, pages 19-29.
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Pavel Pichurin, Jin Guo, Xinmin Yan, Basil Rapoport & Sandra M. McLachlan. (2001) Human Monoclonal Autoantibodies to B-Cell Epitopes Outside the Thyroid Peroxidase Autoantibody Immunodominant Region. Thyroid 11:4, pages 301-313.
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R. Anthony Williamson, Mark P. Burgoon, Gregory P. Owens, Omar Ghausi, Estelle Leclerc, Louise Firme, Sharon Carlson, John Corboy, Paul W. H. I. Parren, Pietro P. Sanna, Donald H. Gilden & Dennis R. Burton. (2001) Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis. Proceedings of the National Academy of Sciences 98:4, pages 1793-1798.
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Nicolas Chapal, Sylvie Peraldi-Roux, Damien Bresson, Martine Pugniere, Jean-Claude Mani, Claude Granier, Line Baldet, Bernard Guerrier, Bernard Pau & Majida Bouanani. (2000) Human Anti-Thyroid Peroxidase Single-Chain Fragment Variable of Ig Isolated from a Combinatorial Library Assembled In-Cell: Insights into the In Vivo Situation. The Journal of Immunology 164:8, pages 4162-4169.
Crossref
David W. J. Coomber, Nicholas J. Hawkins, Michelle A. Clark & Robyn L. Ward. (1999) Generation of Anti-p53 Fab Fragments from Individuals with Colorectal Cancer Using Phage Display. The Journal of Immunology 163:4, pages 2276-2283.
Crossref
Hiroshi SakuraiR. Anthony Williamson, James E. CroweJudy A. BeelerPascal Poignard, Raiza B. Bastidas, Robert M. Chanock & Dennis R. Burton. (1999) Human Antibody Responses to Mature and Immature Forms of Viral Envelope in Respiratory Syncytial Virus Infection: Significance for Subunit Vaccines. Journal of Virology 73:4, pages 2956-2962.
Crossref
Richard Mclntosh, Philip Watson & Anthony Weetman. (1998) Somatic hypermutation in antoimmune thyroid disease. Immunological Reviews 162:1, pages 219-231.
Crossref
A. P. Weetman, R. S. McIntosh & P. F. Watson. 1998. Endocrine Autoimmunity and Associated Conditions. Endocrine Autoimmunity and Associated Conditions 39 61 .
J. Mark Hexham. 1998. Immunochemical Protocols. Immunochemical Protocols 461 474 .
Richard S. McIntoshM. Suhail AsgharE. Helen KempPhilip F. WatsonAndrzej GardasJ. Paul Banga & Anthony P. Weetman. (1997) Analysis of Immunoglobulin Gκ Antithyroid Peroxidase Antibodies from Different Tissues in Hashimoto’s Thyroiditis1. The Journal of Clinical Endocrinology & Metabolism 82:11, pages 3818-3825.
Crossref
Barbara CzarnockaMarek Janota-BzowskiRichard S. McIntoshM. Suhail AsgharPhilip F. WatsonE. Helen KempPierre Carayon & Anthony P. Weetman. (1997) Immunoglobulin Gκ Antithyroid Peroxidase Antibodies in Hashimoto’s Thyroiditis: Epitope-Mapping Analysis1. The Journal of Clinical Endocrinology & Metabolism 82:8, pages 2639-2644.
Crossref
Juan Carlos Jaume, Jin Guo, Ayumu Kakinuma, Basil Rapoport & Sandra M. McLachlan. (1997) The Epitopic “Fingerprint” of Thyroid Peroxidase-Specific Fab Isolated from a Patient's Thyroid Gland by the Combinatorial Library Approach Resembles That of Autoantibodies in the Donor's Serum. Clinical Immunology and Immunopathology 84:2, pages 150-157.
Crossref
R.S. McINTOSH & A.P. WEETMAN. (1997) Molecular Analysis of the Antibody Response to Thyroglobulin and Thyroid Peroxidase. Thyroid 7:3, pages 471-487.
Crossref
Yvo F Graus, Marc H de Baets, Peter J van Breda Vriesman & Dennis R Burton. (1997) Anti-acetylcholine receptor Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. Immunology Letters 57:1-3, pages 59-62.
Crossref
Ruud M. T. de Wildt, Ricarda Finnern, Willem H. Ouwehand, Andrew D. Griffiths, Walther J. van Venrooij & René M. A. Hoet. (2005) Characterization of human variable domain antibody fragments against the U1 RNA‐associated A protein, selected from a synthetic and a patient‐derived combinatorial V gene library. European Journal of Immunology 26:3, pages 629-639.
Crossref
Stefano Portolano, Mark F. Prummel, Basil Rapoport & Sandra M. McLachlan. (1995) Molecular cloning and characterization of human thyroid peroxidase autoantibodies of lambda light chain type. Molecular Immunology 32:14-15, pages 1157-1169.
Crossref
Basil Rapoport, Stefano Portolano & Sandra M. McLachlan. (1995) Combinatorial libraries: new insights into human organ-specific autoantibodies. Immunology Today 16:1, pages 43-49.
Crossref

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