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Autoimmunity Volume 21, 1995 - Issue 2
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Original Article

Increased Activation and Altered Ratio of Interferon-Gamma: Interleukin-4 Secreting Cells in MRL-lpr/lpr Mice

Akira Shirai Section of Retroviral Immunology. Division of Viral Products CBER/FDA., Yokohama City University School of Medicine, Yokohama, Japan; Dept of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
,
Jacqueline Conover Section of Retroviral Immunology. Division of Viral Products CBER/FDA., Yokohama City University School of Medicine, Yokohama, Japan
&
Dennis M. Klinman Section of Retroviral Immunology. Division of Viral Products CBER/FDA., Yokohama City University School of Medicine, Yokohama, Japan
Pages 107-116 | Received 03 May 1995, Published online: 07 Jul 2009

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Takashi Tanaka, Fumitoshi Tago, Su-Ping Fang, Noriko Shimura & Shuji Kojima. (2005) Repeated 0.5-Gy γ-ray irradiation attenuates autoimmune manifestations in MRL-lpr/lpr mice. International Journal of Radiation Biology 81:10, pages 731-740.
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Dwight H. Kono, Roberto Baccala & Argyrios N. Theofilopoulos. (2003) Inhibition of Lupus by Genetic Alteration of the Interferon-α/β Receptor. Autoimmunity 36:8, pages 503-510.
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Allison Sang, Yiming Yin, Ying-Yi Zheng & Laurence Morel. 2012. Animal Models of Molecular Pathology. Animal Models of Molecular Pathology 321 370 .
Maria Gulinello & Chaim Putterman. (2011) The MRL/lpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology 2011, pages 1-15.
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Bo Jin, Richard Y. Wang, Qi Qiu, Fuminaka Sugauchi, Teresa Grandinetti, Harvey J. Alter & J. Wai-Kuo Shih. (2007) Induction of potent cellular immune response in mice by hepatitis C virus NS3 protein with double-stranded RNA. Immunology 122:1, pages 15-27.
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So-Yon Lim & Swapan K. Ghosh. (2005) Autoreactive responses to environmental factors: 3. Mouse strain-specific differences in induction and regulation of anti-DNA antibody responses due to phthalate-isomers. Journal of Autoimmunity 25:1, pages 33-45.
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Chaim O. Jacob, Song Zang, Lily Li, Voicu Ciobanu, Frank Quismorio, Akiei Mizutani, Minoru Satoh & Michael Koss. (2003) Pivotal Role of Stat4 and Stat6 in the Pathogenesis of the Lupus-Like Disease in the New Zealand Mixed 2328 Mice. The Journal of Immunology 171:3, pages 1564-1571.
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Ram Raj Singh. (2003) IL-4 and many roads to lupuslike autoimmunity. Clinical Immunology 108:2, pages 73-79.
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Ram Raj Singh, Vijay Saxena, Song Zang, Lily Li, Fred D. Finkelman, David P. Witte & Chaim O. Jacob. (2003) Differential Contribution of IL-4 and STAT6 vs STAT4 to the Development of Lupus Nephritis. The Journal of Immunology 170:9, pages 4818-4825.
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R A Mageed & G J Prud'homme. (2003) Immunopathology and the gene therapy of lupus. Gene Therapy 10:10, pages 861-874.
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Taisuke Ito, Naohiro Seo, Hiroaki Yagi, Toshio Ohtani, Yoshiki Tokura, Masahiro Takigawa & Fukumi Furukawa. (2002) Unique therapeutic effects of the Japanese–Chinese herbal medicine, Sairei-to, on Th1/Th2 cytokines balance of the autoimmunity of MRL/lpr mice. Journal of Dermatological Science 28:3, pages 198-210.
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Ehsanollah Esfandiari, Iain B. McInnes, George Lindop, Fang-Ping Huang, Max Field, Mousa Komai-Koma, Xiao-qing Wei & Foo Y. Liew. (2001) A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease. The Journal of Immunology 167:9, pages 5338-5347.
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Detlef Neumann, Elda Del Giudice, Antonio Ciaramella, Diana Boraschi & Paola Bossù. (2001) Lymphocytes from Autoimmune MRL lpr/lpr Mice Are Hyperresponsive to IL-18 and Overexpress the IL-18 Receptor Accessory Chain . The Journal of Immunology 166:6, pages 3757-3762.
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Magi Khalil, Kayo Inaba, Ralph Steinman, Jeffrey Ravetch & Betty Diamond. (2001) T Cell Studies in a Peptide-Induced Model of Systemic Lupus Erythematosus. The Journal of Immunology 166:3, pages 1667-1674.
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Yoshihiro OKAMOTO & Mikio NISHIDA. (2001) Cytokine Balance in the Pathogenesis of Rheumatoid Arthritis慢性関節リウマチの発症とサイトカインバランス. YAKUGAKU ZASSHI 121:2, pages 131-138.
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Eri Hagiwara, Tadanobu Okubo, Ichiro Aoki, Shigeru Ohno, Takashi Tsuji, Atsushi Ihata, Atsuhisa Ueda, Akira Shirai, Kenji Okuda, Jun-Ichi Miyazaki & Yoshiaki Ishigatsubo. (2000) IL-12-ENCODING PLASMID HAS A BENEFICIAL EFFECT ON SPONTANEOUS AUTOIMMUNE DISEASE IN MRL/MP-lpr/lpr MICE. Cytokine 12:7, pages 1035-1041.
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A. Krętowski, K. M. Gillespie, P. J. Bingley & & I. Kinalska. (2001) Soluble L‐selectin levels in type I diabetes mellitus: a surrogate marker fordisease activity?. Immunology 99:2, pages 320-325.
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Dwight H. Kono, Dimitrios Balomenos, Miyo S. Park & Argyrios N. Theofilopoulos. (2000) Development of Lupus in BXSB Mice Is Independent of IL-4. The Journal of Immunology 164:1, pages 38-42.
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A. Schwarting, G. Tesch, K. Kinoshita, R. Maron, H. L. Weiner & V. Rubin Kelley. (1999) IL-12 Drives IFN-γ-Dependent Autoimmune Kidney Disease in MRL- Fas lpr Mice . The Journal of Immunology 163:12, pages 6884-6891.
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A. Ihata, S. Watabe, S. Sasaki, A. Shirai, J. Fukushima, K. Hamajima, J. Inoue & K. Okuda. (1999) Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against human immunodeficiency virus type-1. Immunology 98:3, pages 436-442.
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Stephen R. Holdsworth, A. Richard Kitching & Peter G. Tipping. (1999) Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis. Kidney International 55:4, pages 1198-1216.
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Mi-Li Gu, Stephen H Leppla & Dennis M Klinman. (1999) Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen. Vaccine 17:4, pages 340-344.
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Daniela Verthelyi & Dennis M. Klinman. 1999. Lupus. Lupus 361 370 .
Barry S. Handwerger, Irina Luzina, Ludmila da Silva, Catherine E. Storrer & Charles S. Via. 1999. Lupus. Lupus 321 340 .
Walter R. Weiss, Ken J. Ishii, Richard C. Hedstrom, Martha Sedegah, Motohide Ichino, Kerry Barnhart, Dennis M. Klinman & Stephen L. Hoffman. (1998) A Plasmid Encoding Murine Granulocyte-Macrophage Colony-Stimulating Factor Increases Protection Conferred by a Malaria DNA Vaccine. The Journal of Immunology 161:5, pages 2325-2332.
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Yoshihiro Okamoto, Tomoko Abe, Takashi Niwa, Shinobu Mizuhashi & Mikio Nishida. (1998) Development of a dual color enzyme-linked immunospot assay for simultaneous detection of murine T helper type 1- and T helper type 2-cells. Immunopharmacology 39:2, pages 107-116.
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Eri Hagiwara, Yoshiaki Ishigatsubo & Dennis M. Klinman. (1997) B cell activation in patients with rheumatic disease: association with an increased ratio of Th2: Th1 cytokine secreting cells. Japanese Journal of Rheumatology 7:3, pages 145-152.
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