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Autoimmunity Volume 22, 1995 - Issue 3
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Original Article

T Cell Proliferative Responses to Glutamic Acid Decarboxylase-65 in IDDM are Negatively Associated with HLA DR3/4

Anne Worsaae Diabetes Immunology, Novo-Nordisk A/S, DK-2880, Bagsvaerd, Denmark
,
Kim Hejnæs Diabetes Immunology, Novo-Nordisk A/S, DK-2880, Bagsvaerd, Denmark
,
Alister Moody Diabetes Immunology, Novo-Nordisk A/S, DK-2880, Bagsvaerd, Denmark
,
Johnny Ludvigsson Department of Paediatrics, Faculty of Health Sciences, S-58185, Linköping, Sweden
,
Flemming Pociot Steno Diabetes Center, DK-2820, Gentofte, Denmark
,
Tove Lorenzen Steno Diabetes Center, DK-2820, Gentofte, Denmark
&
Thomas Dyrberg Diabetes Immunology, Novo-Nordisk A/S, DK-2880, Bagsvaerd, Denmark
 show all
Pages 183-189 | Received 29 Nov 1995, Published online: 07 Jul 2009

Citations (15)

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Susan A. Masewicz, Niecey Meldrum, Vivian Gersuk, Lakshmi Gaur, William Hagopian, Lori Moriarity & Gerald T. Nepom. (2001) Complexity of Human Immune Response Profiles for CD4+ T Cell Epitopes from the Diabetes Autoantigen GAD65. Autoimmunity 34:4, pages 231-240.
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Paolo Pozzilli, Silvia Manfrini, Laura Monetini. (2001) Biochemical markers of type 1 diabetes: clinical use. Scandinavian Journal of Clinical and Laboratory Investigation 61:235, pages 38-44.
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Articles from other publishers (13)

Damien Bresson, Matthew Fradkin, Yulia Manenkova, Diane Rottembourg & Matthias von Herrath. (2010) Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes. Molecular Therapy 18:2, pages 307-316.
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Corine A. van Kampen, Pieter van de Linde, Gaby Duinkerken, Jolien J. van Schip, Dave L. Roelen, Bart Keymeulen, Daniel G. Pipeleers, Frans H.J. Claas & Bart O. Roep. (2005) Alloreactivity Against Repeated HLA Mismatches of Sequential Islet Grafts Transplanted in Non-Uremic Type 1 Diabetes Patients. Transplantation 80:1, pages 118-126.
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Timothy I.M. Tree, Gaby Duinkerken, Sabine Willemen, René R.P. de Vries & Bart O. Roep. (2004) HLA-DQ–Regulated T-Cell Responses to Islet Cell Autoantigens Insulin and GAD65. Diabetes 53:7, pages 1692-1699.
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Gerald T. Nepom. (2003) Conversations with GAD. Journal of Autoimmunity 20:3, pages 195-198.
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Bart O. Roep. (2003) The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure. Diabetologia 46:3, pages 305-321.
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. 2002. Immunotoxicology and Risk Assessment. Immunotoxicology and Risk Assessment 283 370 .
P Klemetti, P Björses, T Tuomi, J Perheentupa, J Partanen, N Rautonen, A Hinkkanen, J Ilonen & O Vaarala. (2000) Autoimmunity to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED). Clinical and Experimental Immunology 119:3, pages 419-425.
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Gerald T. Nepom, John D. Lippolis, Forest M. White, Susan Masewicz, Jarrod A. Marto, Andrew Herman, C. John Luckey, Ben Falk, Jeffrey Shabanowitz, Donald F. Hunt, Victor H. Engelhard & Barbara S. Nepom. (2001) Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65). Proceedings of the National Academy of Sciences 98:4, pages 1763-1768.
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Maria G.E. Karlsson & Johnny Ludvigsson. (2000) The ABBOS-peptide from bovine serum albumin causes an IFN-γ and IL-4 mRNA response in lymphocytes from children with recent onset of type 1 diabetes. Diabetes Research and Clinical Practice 47:3, pages 199-207.
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Bart O Roep, Mark A Atkinson, Peter M van Endert, Peter A Gottlieb, S.Brian Wilson & Johnny A Sachs. (1999) Autoreactive T cell Responses in Insulin-dependent (Type 1) Diabetes Mellitus. Report of the First International Workshop for Standardization of T cell assays. Journal of Autoimmunity 13:2, pages 267-282.
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M.G.E Karlsson & J Ludvigsson. (1998) Determination of mRNA expression for IFN-γ and IL-4 in lymphocytes from children with IDDM by RT-PCR technique. Diabetes Research and Clinical Practice 40:1, pages 21-30.
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A. Plesner & Å. Lernmark. 1998. Endocrine Autoimmunity and Associated Conditions. Endocrine Autoimmunity and Associated Conditions 113 144 .
Jean-Marie Bach, Heike Otto, Gerald T. Nepom, Günther Jung, Hélène Cohen, José Timsit, Christian Boitard & Peter M. van Endert. (1997) High Affinity Presentation of an Autoantigenic Peptide in Type I Diabetes by an HLA Class II Protein Encoded in a Haplotype Protecting From Disease. Journal of Autoimmunity 10:4, pages 375-386.
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