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Review Article

Manipulation of the Th1/Th2 Cell Balance: An Approach to Treat Human Autoimmune Diseases?

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Pages 53-68 | Received 22 Jan 1996, Published online: 07 Jul 2009

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M A FRASSANITO, R DAMMACCO, T FUSARO, A CUSMAI, S GUERRIERO & C SBORGIA. (2003) Combined cyclosporin-A /prednisone therapy of patients with active uveitis suppresses IFN- γ  production and the function of dendritic cells . Clinical and Experimental Immunology 133:2, pages 233-239.
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Alison Finnegan, Katalin Mikecz, Ping Tao & Tibor T. Glant. (1999) Proteoglycan (Aggrecan)-Induced Arthritis in BALB/c Mice Is a Th1-Type Disease Regulated by Th2 Cytokines. The Journal of Immunology 163:10, pages 5383-5390.
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Tanja Aarvak, Martine Chabaud, Pierre Miossec & Jacob B. Natvig. (1999) IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells. The Journal of Immunology 162:3, pages 1246-1251.
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Richard A. Mann, Devora Schiff, Amanda E. Jetzt, Yacov Ron, Manjeet Singh & Ajay B. Singh. (1998) CD8+, Radiosensitive T Cells of Parental Origin, Oppose Cells Capable of Down-Regulating Cytotoxicity in Murine Acute Lethal Graft-versus-Host Disease. Clinical Immunology and Immunopathology 89:3, pages 260-270.
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J.R. Kalden, F.C. Breedveld, H. Burkhardt & G.R. Burmester. 1998. Advances in Immunology Volume 68. Advances in Immunology Volume 68 333 418 .

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