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Original Article

Cytokine Gene Expression and Autoantibody Production in Sjögren's Syndrome of MRL/lpr Mice

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Pages 269-277 | Received 19 Apr 1996, Published online: 07 Jul 2009

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Kazuo Ohba, Katsuhisa Omagari, Kunihiko Murase, Hiroaki Hazama, Jun-ichi Masuda, Hideki Kinoshita, Hajime Isomoto, Yohei Mizuta, Masanobu Miyazaki, Ikuo Murata & Shigeru Kohno. (2002) A possible mouse model for spontaneous cholangitis: serological and histological characteristics of MRL/ lpr mice. Pathology 34:3, pages 250-256.
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MARTIN KILLIAN, FRÉDÉRIC BATTEUX & STÉPHANE PAUL. (2020) The MRL/lpr Mouse Model: An Important Animal Model for Systemic Sjögren Syndrome and Polyautoimmunity. The Journal of Rheumatology 47:1, pages 157-157.
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Jingjing Qi, Dan Li, Guoping Shi, Xuefang Zhang, Yuchen Pan, Huan Dou, Tingting Wang, Genhong Yao & Yayi Hou. (2019) Interleukin‑12 exacerbates Sj�gren's syndrome through induction of myeloid‑derived suppressor cells. Molecular Medicine Reports.
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Axel R. Concepcion & Juan F. Medina. (2012) Approaches to the pathogenesis of primary biliary cirrhosis through animal models. Clinics and Research in Hepatology and Gastroenterology 36:1, pages 21-28.
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A. Mustafa, S.D. Holladay, S. Witonsky, D.P. Sponenberg, E. Karpuzoglu & R.M. GogalJr.Jr.. (2011) A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology 290:2-3, pages 156-168.
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Amjad Mustafa, Steven D. Holladay, Matthew Goff, Sharon Witonsky, Richard Kerr, Danielle A. Weinstein, Ebru Karpuzoglu‐Belgin & Robert M. GogalJrJr. (2009) Developmental exposure to 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin alters postnatal T cell phenotypes and T cell function and exacerbates autoimmune lupus in 24‐week‐old SNF 1 mice . Birth Defects Research Part A: Clinical and Molecular Teratology 85:10, pages 828-836.
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Cuong Q. Nguyen & Ammon B. Peck. (2009) Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease. The Ocular Surface 7:1, pages 11-27.
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S. Cha, J. Brayer, J. Gao, V. Brown, S. Killedar, U. Yasunari & A. B. Peck. (2004) A Dual Role for Interferon-gamma in the Pathogenesis of Sjogren's Syndrome-Like Autoimmune Exocrinopathy in the Nonobese Diabetic Mouse. Scandinavian Journal of Immunology 60:6, pages 552-565.
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Stephen Pflugfelder, Roger Beuerman & Michael SternPedram Hamrah, Syed Huq, Abha Gulati & Reza Dana. 2004. Dry Eye and Ocular Surface Disorders. Dry Eye and Ocular Surface Disorders 111 141 .
Takanori Azuma, Masami Takei, Tsutomu Yoshikawa, Yumi Nagasugi, Masaki Kato, Motoyuki Otsuka, Hidetaka Shiraiwa, Sumino Sugano, Ko Mitamura, Shigemasa Sawada, Yasuhiko Masuho & Naohiko Seki. (2002) Identification of candidate genes for Sjögren's syndrome using MRL/lpr mouse model of Sjögren's syndrome and cDNA microarray analysis. Immunology Letters 81:3, pages 171-176.
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Saskia C.A. van Blokland & Marjan A. Versnel. (2002) Pathogenesis of Sjögren's Syndrome: Characteristics of Different Mouse Models for Autoimmune Exocrinopathy. Clinical Immunology 103:2, pages 111-124.
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E Karpuzoglu-Sahin, B.D Hissong & S Ansar Ahmed. (2001) Interferon-γ levels are upregulated by 17-β-estradiol and diethylstilbestrol. Journal of Reproductive Immunology 52:1-2, pages 113-127.
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Koichi Tsuneyama, Masato Nose, Miyuki Nisihara, Kazuyoshi Katayanagi, Kenichi Harada & Yasuni Nakanuma. (2001) Spontaneous occurrence of chronic non‐suppurative destructive cholangitis and antimitochondrial autoantibodies in MRL/ lpr mice: Possible animal model for primary biliary cirrhosis . Pathology International 51:6, pages 418-424.
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E. Karpuzoglu-Sahin, Y. Zhi-Jun, A. Lengi, N. Sriranganathan & S. Ansar Ahmed. (2001) EFFECTS OF LONG-TERM ESTROGEN TREATMENT ON IFN-γ, IL-2 AND IL-4 GENE EXPRESSION AND PROTEIN SYNTHESIS IN SPLEEN AND THYMUS OF NORMAL C57BL/6 MICE. Cytokine 14:4, pages 208-217.
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Miyuki Nishihara, Miho Terada, Junji Kamogawa, Yuichi Ohashi, Shiro Mori, Shuichi Nakatsuru, Yusuke Nakamura & Masato Nose. (1999) Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: Additive and hierarchical properties of polygenic inheritance. Arthritis & Rheumatism 42:12, pages 2616-2623.
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Owen T. M. Chan, Michael R Madaio, Mark J. Shlomchik, Owen I. M. Chan, Michael P. Madaio & Mark J. Shlomchik. (2006) The central and multiple roles of B cells in lupus pathogenesis. Immunological Reviews 169:1, pages 107-121.
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Giorgio Trinchieri. 1998. Advances in Immunology Volume 70. Advances in Immunology Volume 70 83 243 .

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