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Autoimmunity Volume 24, 1996 - Issue 1
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Original Article

Abnormalities in the Export and Fate of Recent Thymic Emigrants in Diabetes-Prone BB/W Rats1

Homayoun H. Zadeh Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT, 06030
,
Dale L. Greiner Division of Diabetes, University of Massachusetts Medical Center, Worcester, MA, 01605, USA
,
Dianna Y. Wu Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT, 06030
,
Frances Tausche Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT, 06030
&
Irving Goldschneider Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT, 06030
Pages 35-46 | Received 11 Dec 1995, Accepted 26 Mar 1996, Published online: 07 Jul 2009

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Sabine Bieg. (1999) Differential Expression of p95vav in Primary Lymphoid Tissue of BB Rats Congenic for the Lymphopenia Gene. Autoimmunity 30:1, pages 37-42.
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Neal N. Iwakoshi, Dale L. Greiner, Aldo A. Rossini & John P. Mordes. (1999) Diabetes Prone BB Rats are Severely Deficient in Natural Killer T Cells. Autoimmunity 31:1, pages 1-14.
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Marc-André Limoges, Maryse Cloutier, Madhuparna Nandi, Subburaj Ilangumaran & Sheela Ramanathan. (2021) The GIMAP Family Proteins: An Incomplete Puzzle. Frontiers in Immunology 12.
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Daniel Serrano, Farnaz Ghobadi, Guylain Boulay, Subburaj Ilangumaran, Christine Lavoie & Sheela Ramanathan. (2017) GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Frontiers in Immunology 8.
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Preeta Datta, Louise M.C. Webb, Inxhina Avdo, John Pascall & Geoffrey W. Butcher. (2017) Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice. European Journal of Immunology 47:1, pages 84-93.
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Bradley T. Gao, Ryan P. Lee, Youde Jiang, Jena J. Steinle & Vanessa M. Morales-Tirado. (2015) Pioglitazone alters monocyte populations and stimulates recent thymic emigrants in the BBDZR/Wor type 2 diabetes rat model. Diabetology & Metabolic Syndrome 7:1.
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Mehari Endale, H. Ibrahim Aksoylar & Kasper Hoebe. (2015) Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut. Mediators of Inflammation 2015, pages 1-11.
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J Sarmiento, R H Wallis, T Ning, L Marandi, G Y C Chao, A D Paterson & P Poussier. (2014) Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat. Genes & Immunity 15:6, pages 378-391.
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Xi Lin Chen, Daniel Serrano, Marian Mayhue, Hans-Joachim Wieden, Jana Stankova, Guylain Boulay, Subburaj Ilangumaran & Sheela Ramanathan. (2012) GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation. Biochemical Journal 449:2, pages 353-364.
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Ulla Nøhr Dalberg, Claus Haase, Lars Hornum & Helle Markholst. 2011. Immunoendocrinology: Scientific and Clinical Aspects. Immunoendocrinology: Scientific and Clinical Aspects 183 197 .
Subburaj Ilangumaran, Melissa Forand-Boulerice, Simon M. Bousquet, Alexandre Savard, Philippe Rocheleau, Xi Lin Chen, Gilles Dupuis, Philippe Poussier, Guylain Boulay & Sheela Ramanathan. (2009) Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes. Molecular Immunology 46:6, pages 1256-1259.
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Jaime F. Modiano, Lisa D. S. Johnson & Donald Bellgrau. (2008) Negative regulators in homeostasis of naïve peripheral T cells. Immunologic Research 41:2, pages 137-153.
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Mamadou Keita, Chantal Leblanc, David Andrews & Sheela Ramanathan. (2007) GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment. Biochemical and Biophysical Research Communications 361:2, pages 481-486.
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Takeshi Nitta & Yousuke Takahama. (2007) The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins. Trends in Immunology 28:2, pages 58-65.
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Rene Kupfer, Julie Lang, Cheryll Williams-Skipp, Matt Nelson, Donald Bellgrau & Robert I. Scheinman. (2007) Loss of a gimap/ian gene leads to activation of NF-κB through a MAPK-dependent pathway. Molecular Immunology 44:4, pages 479-487.
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Jacek M. Witkowski. 2007. Immunosenescence. Immunosenescence 80 91 .
Jan-Luuk Hillebrands, Barbara Whalen, Jeroen T. J. Visser, Jasper Koning, Kenneth D. Bishop, Jean Leif, Jan Rozing, John P. Mordes, Dale L. Greiner & Aldo A. Rossini. (2006) A Regulatory CD4+ T Cell Subset in the BB Rat Model of Autoimmune Diabetes Expresses Neither CD25 Nor Foxp3. The Journal of Immunology 177:11, pages 7820-7832.
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Lesley Cousins, Margaret Graham, Reuben Tooze, Christine Carter, J. Ross Miller, Fiona M. Powrie, Gordon G. Macpherson & Geoffrey W. Butcher. (2006) Eosinophilic Bowel Disease Controlled by the BB Rat-Derived Lymphopenia/Gimap5 Gene. Gastroenterology 131:5, pages 1475-1485.
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B.C. Beaudette-Zlatanova, B. Whalen, D. Zipris, H. Yagita, J. Rozing, H. Groen, C.D. Benjamin, T. Hunig, H.A. Drexhage, M.J. Ansari, J. Leif, J.P. Mordes, D.L. Greiner, M.H. Sayegh & A.A. Rossini. (2006) Costimulation and Autoimmune Diabetes in BB Rats. American Journal of Transplantation 6:5, pages 894-902.
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Tyson Hawkins, Jessica Fuller, Kara Olson, Sara Speros & ?ke Lernmark. (2005) DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats. Journal of Autoimmunity 25:4, pages 251-257.
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Philippe Poussier, Terri Ning, Trista Murphy, Dominika Dabrowski & Sheela Ramanathan. (2005) Impaired Post-Thymic Development of Regulatory CD4+25+ T Cells Contributes to Diabetes Pathogenesis in BB Rats. The Journal of Immunology 174:7, pages 4081-4089.
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Stuart P. Berzins, Emily S. Venanzi, Christophe Benoist & Diane Mathis. (2003) T-Cell Compartments of Prediabetic NOD Mice. Diabetes 52:2, pages 327-334.
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Irving Goldschneider & Robert E. Cone. (2003) A central role for peripheral dendritic cells in the induction of acquired thymic tolerance. Trends in Immunology 24:2, pages 77-81.
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Sheela Ramanathan, Marie-Therese BihoreauAndrew D. Paterson, Leili Marandi, Dominique GauguierPhilippe Poussier. (2002) Thymectomy and Radiation-Induced Type 1 Diabetes in Nonlymphopenic BB Rats. Diabetes 51:10, pages 2975-2981.
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Lars Hornum, John Rømer & Helle Markholst. (2002) The Diabetes-Prone BB Rat Carries a Frameshift Mutation in Ian4 , a Positional Candidate of Iddm1 . Diabetes 51:6, pages 1972-1979.
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Sheela Ramanathan, Leili Marandi & Philippe Poussier. (2002) Evidence for the Extrathymic Origin of Intestinal TCRγδ+ T Cells in Normal Rats and for an Impairment of This Differentiation Pathway in BB Rats. The Journal of Immunology 168:5, pages 2182-2187.
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Argyrios N. Theofilopoulos, Wolfgang Dummer & Dwight H. Kono. (2001) T cell homeostasis and systemic autoimmunity. Journal of Clinical Investigation 108:3, pages 335-340.
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Lars Hornum & Helle Markholst. (2000) A Sequence-Ready PAC Contig of a 550-kb Region on Rat Chromosome 4 Including the Diabetes Susceptibility Gene Lyp. Genomics 69:3, pages 305-313.
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Edward SeungNeal IwakoshiBruce A. WodaThomas G. MarkeesJohn P. MordesAldo A. RossiniDale L. Greiner. (2000) Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood 95:6, pages 2175-2182.
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Neal N. Iwakoshi, John P. Mordes, Thomas G. Markees, Nancy E. Phillips, Aldo A. Rossini & Dale L. Greiner. (2000) Treatment of Allograft Recipients with Donor-Specific Transfusion and Anti-CD154 Antibody Leads to Deletion of Alloreactive CD8+ T Cells and Prolonged Graft Survival in a CTLA4-Dependent Manner. The Journal of Immunology 164:1, pages 512-521.
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C.‐G. Jung, T. Kamiyama & T. Agui. (2001) Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats. Immunology 98:4, pages 590-594.
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Dianna Y. Wu & Irving Goldschneider. (1999) Cyclosporin A-Induced Autologous Graft-Versus-Host Disease: A Prototypical Model of Autoimmunity and Active (Dominant) Tolerance Coordinately Induced by Recent Thymic Emigrants. The Journal of Immunology 162:11, pages 6926-6933.
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Gabriela Hernández-Hoyos, Sarah Joseph, Nigel G. A. Miller & Geoffrey W. Butcher. (1999) Thelymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes. European Journal of Immunology 29:6, pages 1832-1841.
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Sheela Ramanathan & Philippe Poussier. (1999) T Cell Reconstitution of BB/W Rats After the Initiation of Insulitis Precipitates the Onset of Diabetes. The Journal of Immunology 162:9, pages 5134-5142.
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L Hornum & H Markholst. (1999) Genetic map of the lymphopenia region on rat chromosome 4. Transplantation Proceedings 31:3, pages 1615-1617.
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J.K Moore & D Bellgrau. (1999) Promiscuous activation and cell cycle entry in T cells from autoimmune animals. Transplantation Proceedings 31:3, pages 1606-1610.
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Jodene K. Moore, Daniel P. Gold, Stephen C. Dreskin, Åke Lernmark & Donald Bellgrau. (1999) A Diabetogenic Gene Prevents T Cells from Receiving Costimulatory Signals. Cellular Immunology 194:1, pages 90-97.
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Barbara J. Whalen, Peter Weiser, Jan Marounek, Aldo A. Rossini, John P. Mordes & Dale L. Greiner. (1999) Recapitulation of Normal and Abnormal BioBreeding Rat T Cell Development in Adult Thymus Organ Culture. The Journal of Immunology 162:7, pages 4003-4012.
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Derrick Todd, Amrik J Singh, Dale L Greiner, John P Mordes, Aldo A Rossini & Rita Bortell. (1999) A new isolation method for rat intraepithelial lymphocytes. Journal of Immunological Methods 224:1-2, pages 111-127.
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Frans G. A. Delemarre, Peter J. Simons, Hendrik Jan de Heer & Hemmo A. Drexhage. (1999) Signs of Immaturity of Splenic Dendritic Cells from the Autoimmune Prone Biobreeding Rat: Consequences for the In Vitro Expansion of Regulator and Effector T Cells. The Journal of Immunology 162:3, pages 1795-1801.
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Rita Bortell, Toshihiro Kanaitsuka, Linda A. Stevens, Joel Moss, John P. Mordes, Aldo A. Rossini & Dale L. Greiner. 1999. ADP-Ribosylation Reactions: From Bacterial Pathogenesis to Cancer. ADP-Ribosylation Reactions: From Bacterial Pathogenesis to Cancer 61 68 .
Neal N. Iwakoshi, Irving Goldschneider, Frances Tausche, John P. Mordes, Aldo A. Rossini & Dale L. Greiner. (1998) High Frequency Apoptosis of Recent Thymic Emigrants in the Liver of Lymphopenic Diabetes-Prone BioBreeding Rats. The Journal of Immunology 160:12, pages 5838-5850.
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Sheela Ramanathan, Ken Norwich & Philippe Poussier. (1998) Antigen Activation Rescues Recent Thymic Emigrants from Programmed Cell Death in the BB Rat. The Journal of Immunology 160:12, pages 5757-5764.
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