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Autoimmunity Volume 25, 1997 - Issue 3
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Original Article

Expression of the Gastric H/K-ATPase α-Subunit in the Thymus may Explain the Dominant Role of the β-Subunit in the Pathogenesis of Autoimmune Gastritis

Frank Alderuccio Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, Melbourne, AustraliaCorrespondence[email protected]
,
Paul A. Gleeson Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, Melbourne, Australia
,
Stuart P. Berzins Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, Melbourne, Australia
,
Marianne Martin CNRS, University Montpellier II, Montpellier, France
,
Ian R. Van Driel Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, Melbourne, Australia
&
Ban-Hock Toh Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, Melbourne, Australia
Pages 167-175 | Received 12 Aug 1996, Published online: 07 Jul 2009

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Yang-Yang Bao, Qian Jiang, Zhen-Wei Li, Er Yu, Shui-Hong Zhou, Hong-Tian Yao, Jun Fan & Wei-Wei Yong. (2020) Gastric H+/K+-ATPase Expression in Normal Laryngeal Tissue and Laryngeal Carcinoma. OncoTargets and Therapy 13, pages 12919-12931.
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Zhe Zhang, Yang-Yang Bao & Shui-Hong Zhou. (2020) Pump Proton and Laryngeal H+/K+ ATPases. International Journal of General Medicine 13, pages 1509-1514.
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Michael Herrmann, Jens Selige, Sandra Raffael, George Sachs, Andrea Brambilla & Thomas Klein. (2007) Systematic expression profiling of the gastric H+/K+ ATPase in human tissue. Scandinavian Journal of Gastroenterology 42:11, pages 1275-1288.
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Mathijs P. Bergman, Christina M. J. E. Vandenbroucke-Grauls, Ben J. Appelmelk, Mario M. D'Elios, Amedeo Amedei, Annalisa Azzurri, Marisa Benagiano & Gianfranco Del Prete. (2005) The Story So Far: Helicobacter Pylori and Gastric Autoimmunity. International Reviews of Immunology 24:1-2, pages 63-91.
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J. Field, M. A. Biondo, K. Murphy, F. Alderuccio & B. H. Toh. (2005) Experimental Autoimmune Gastritis: Mouse Models Of Human Organ-specific Autoimmune Disease. International Reviews of Immunology 24:1-2, pages 93-110.
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Senga Whittingham & Ian R. Mackay. (2005) Autoimmune Gastritis: Historical Antecedents, Outstanding Discoveries, and Unresolved Problems. International Reviews of Immunology 24:1-2, pages 1-29.
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Frank Alderuccio, Kim Murphy, Mark Biondo, Judith Field & Ban-Hock Toh. (2005) Reversing the Autoimmune Condition: Experience with Experimental Autoimmune Gastritis. International Reviews of Immunology 24:1-2, pages 135-155.
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Frank Alderuccio & Ban-Hock Toh. (2004) Induction of tolerance to self-antigens using genetically modified bone marrow cells. Expert Opinion on Biological Therapy 4:7, pages 1007-1014.
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Elisabet Cantó, Silvia Vidal & José Luis Rodríguez-Sánchez. (2003) HK-ATPase Expression in the Susceptible BALB/c and the Resistant DBA/2 Strains of Mice to Autoimmune Gastritis. Autoimmunity 36:5, pages 275-283.
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Harini D. De Silva, Frank Alderuccio, Ban Hock Toh, Ian R. Van Driel & Paul A. GleesOn. (2001) Defining T Cell Receptors which Recognise the Immunodominant Epitope of the Gastric Autoantigen, the H/K ATPase β-Subunit. Autoimmunity 33:1, pages 1-14.
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D.M. Cauvi, P. Hultman & K.M. Pollard. 2018. Comprehensive Toxicology. Comprehensive Toxicology 498 523 .
Sarah A. Overall, Dorothée Bourges, Ian R. van Driel & Paul A. Gleeson. (2017) Increased endogenous antigen presentation in the periphery enhances susceptibility to inflammation-induced gastric autoimmunity in mice. European Journal of Immunology 47:1, pages 155-167.
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Fabio Cominelli, Kristen O. Arseneau, Matthew J. Hamilton & Richard S. Blumberg. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 284 316 .
D.M. Cauvi, P. Hultman & K.M. Pollard. 2015. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Ellen M. Ross, Dorothée Bourges, Thea V. Hogan, Paul A. Gleeson & Ian R. van Driel. (2014) Helios defines T cells being driven to tolerance in the periphery and thymus. European Journal of Immunology 44:7, pages 2048-2058.
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Ban-Hock Toh, James Chan, Tin Kyaw & Frank Alderuccio. (2010) Cutting Edge Issues in Autoimmune Gastritis. Clinical Reviews in Allergy & Immunology 42:3, pages 269-278.
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D.M. Cauvi, K.M. Pollard & P. Hultman. 2010. Comprehensive Toxicology. Comprehensive Toxicology 413 438 .
João P. Monteiro, Julia Farache, Ana Carolina Mercadante, Julio A. Mignaco, Martin Bonamino & Adriana Bonomo. (2008) Pathogenic Effector T Cell Enrichment Overcomes Regulatory T Cell Control and Generates Autoimmune Gastritis. The Journal of Immunology 181:9, pages 5895-5903.
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Thea V. Hogan, Desmond K.Y. Ang, Paul A. Gleeson & Ian R. van Driel. (2008) Extrathymic mechanisms of T cell tolerance: Lessons from autoimmune gastritis. Journal of Autoimmunity 31:3, pages 268-273.
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Deanne L.V. Greenwood & John W. Sentry. (2007) Murine experimental autoimmune gastritis models refractive to development of intrinsic factor autoantibodies, cobalamin deficiency and pernicious anemia. Clinical Immunology 122:1, pages 41-52.
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Tricia D. Zwar, Simon Read, Ian R. van Driel & Paul A. Gleeson. (2006) CD4+CD25+ Regulatory T Cells Inhibit the Antigen-Dependent Expansion of Self-Reactive T Cells In Vivo. The Journal of Immunology 176:3, pages 1609-1617.
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Ian R van Driel, Simon Read, Tricia D Zwar & Paul A Gleeson. (2005) Shaping the T cell repertoire to a bona fide autoantigen: lessons from autoimmune gastritis. Current Opinion in Immunology 17:6, pages 570-576.
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Stacey Allen, Simon Read, Richard DiPaolo, Rebecca S. McHugh, Ethan M. Shevach, Paul A. Gleeson & Ian R. van Driel. (2005) Promiscuous Thymic Expression of an Autoantigen Gene Does Not Result in Negative Selection of Pathogenic T Cells. The Journal of Immunology 175:9, pages 5759-5764.
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Gerhard Faller & Thomas Kirchner. (2004) Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. Virchows Archiv 446:1, pages 1-9.
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R. S. McHugh. 2005. CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential. CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential 153 177 .
Juan J Lafaille. (2004) T-cell receptor transgenic mice in the study of autoimmune diseases. Journal of Autoimmunity 22:2, pages 95-106.
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Judith Field, Aiden C.J Marshall, Paul J. Hertzog, Timothy N Wells, Frank Alderuccio & Ban-Hock Toh. (2003) Chemokine receptor CCR5 is not required for development of experimental autoimmune gastritis. Clinical Immunology 109:2, pages 238-247.
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H. SHIONO, I. ROXANIS, W. ZHANG, G. P. SIMS, A. MEAGER, L. W. JACOBSON, J-L. LIU, I. MATTHEWS, Y-L. WONG, M. BONIFATI, K. MICKLEM, D. I. STOTT, J. A. TODD, D. BEESON, A. VINCENT & N. WILLCOX. (2003) Scenarios for Autoimmunization of T and B Cells in Myasthenia Gravis. Annals of the New York Academy of Sciences 998:1, pages 237-256.
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Frank Alderuccio, Kim Murphy & Ban-Hock Toh. (2003) Stem cells engineered to express self-antigen to treat autoimmunity. Trends in Immunology 24:4, pages 176-180.
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Patrice Tran ba huy & Éric Lecain. (2002) Contribution à l’étude de l’homéostasie de l’endolymphe. Bulletin de l'Académie Nationale de Médecine 186:7, pages 1269-1288.
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Karen L. Laurie, Ian R. van Driel, Tricia D. Zwar, Simon P. Barrett & Paul A. Gleeson. (2002) Endogenous H/K ATPase β-Subunit Promotes T Cell Tolerance to the Immunodominant Gastritogenic Determinant. The Journal of Immunology 169:5, pages 2361-2367.
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Frank Alderuccio, John W. Sentry, Aiden C.J. Marshall, Mark Biondo & Ban Hock Toh. (2002) Animal Models of Human Disease: Experimental Autoimmune Gastritis—A Model for Autoimmune Gastritis and Pernicious Anemia. Clinical Immunology 102:1, pages 48-58.
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Katrina L. Scarff, Louise M. Judd, Wendy E. Wilson, Karen L. Laurie, Ban‐Hock Toh, Paul A. Gleeson & Ian R. Van Driel. (2002) Requirements for autoimmune responses to mouse gastric autoantigens. Immunology 104:4, pages 392-401.
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Rebecca S. McHugh, Ethan M. Shevach, David H. Margulies & Kannan Natarajan. (2001) A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity. European Journal of Immunology 31:7, pages 2094-2103.
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Mathijs P. Bergman, Gerhard Faller, Mario M. D'Elios, Gianfranco Del Prete, Christina M. J. E. Vandenbroucke-Grauls & Ben J. Appelmelk. 2001. Helicobacter pylori. Helicobacter pylori 429 440 .
Mark Biondo, Zeyad Nasa, Aiden Marshall, Ban Hock Toh & Frank Alderuccio. (2001) Local Transgenic Expression of Granulocyte Macrophage-Colony Stimulating Factor Initiates Autoimmunity. The Journal of Immunology 166:3, pages 2090-2099.
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Eric Lecain, Jean-Claude Robert, Annick Thomas & Patrice Tran Ba Huy. (2000) Gastric proton pump is expressed in the inner ear and choroid plexus of the rat. Hearing Research 149:1-2, pages 147-154.
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Ban-Hock Toh, John William Sentry & Frank Alderuccio. (2000) The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis. Immunology Today 21:7, pages 348-354.
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Ethan M. Shevach. (2000) Regulatory T Cells in Autoimmmunity. Annual Review of Immunology 18:1, pages 423-449.
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Frank Alderuccio, Valenzio Cataldo, Ian R. van Driel, Paul A. Gleeson & Ban Hock Toh. (2000) Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice. International Immunology 12:3, pages 343-352.
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Marguerite Hill, David Beeson, Paul Moss, Leslie Jacobson, Alison Bond, Louise Corlett, John Newsom-Davis, Angela Vincent & Nick Willcox. (1999) Early-onset myasthenia gravis: A recurring T-cell epitope in the adult-specific acetylcholine receptor ? subunit presented by the susceptibility allele HLA-DR52a. Annals of Neurology 45:2, pages 224-231.
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Elisabeth Suri-Payer, Anna Z. Amar, Rebecca McHugh, Kannan Natarajan, David H. Margulies & Ethan M. Shevach. (1999) Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase- reactive T cells. European Journal of Immunology 29:2, pages 669-677.
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DE SILVA, GLEESON, TOH, VAN DRIEL & CARBONE. (2001) Identification of a gastritogenic epitope of the H/K ATPase β‐subunit. Immunology 96:1, pages 145-151.
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George Sachs & Björn Wallmark. 1999. Proton Pump Inhibitors. Proton Pump Inhibitors 23 45 .
Frank Alderuccio & Ban Hock Toh. (1998) Spontaneous Autoimmune Gastritis in C3H/He Mice. The American Journal of Pathology 153:4, pages 1311-1318.
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A. Lee. 1998. Helicobacter pylori. Helicobacter pylori 473 482 .

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