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Autoimmunity Volume 28, 1998 - Issue 4
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Original Article

The Inhibitory Effect in Experimental Autoimmune Encephalomyelitis by the Immunomodulatory Drug Linomide (PNU-212616) is not Mediated via Release of Endogenous Glucocorticoids

O. Pekarskia Department of Experimental Therapy, Lund Research Center, Pharmacia and Upjohn, Box 724, S-220 07, Lund, SwedenCorrespondence[email protected]
,
J. Björka Department of Experimental Therapy, Lund Research Center, Pharmacia and Upjohn, Box 724, S-220 07, Lund, Sweden
,
G. Hedlunda Department of Experimental Therapy, Lund Research Center, Pharmacia and Upjohn, Box 724, S-220 07, Lund, Sweden;b The Wallenberg Laboratory, Lund University, Lund, Sweden
&
G. Anderssona Department of Experimental Therapy, Lund Research Center, Pharmacia and Upjohn, Box 724, S-220 07, Lund, Sweden;c Department of Animal Physiology, Lund University, Lund, Sweden
Pages 235-241 | Received 21 Jan 1998, Published online: 07 Jul 2009

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Holger M Reichardt, Ralf Gold & Fred Lühder. (2006) Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis. Expert Review of Neurotherapeutics 6:11, pages 1657-1670.
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De-Hyung Lee & Ralf A Linker. (2012) Clinical and experimental data on the use of laquinimod for the treatment of multiple sclerosis. Clinical Investigation 2:8, pages 819-824.
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M. Dimitrijević, A. Rauški, K. Radojević, D. Kosec, S. Stanojević, I. Pilipović & G. Leposavić. (2007) β-adrenoceptor blockade ameliorates the clinical course of experimental allergic encephalomyelitis and diminishes its aggravation in adrenalectomized rats. European Journal of Pharmacology 577:1-3, pages 170-182.
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Stig Jönsson, Gunnar Andersson, Tomas Fex, Tomas Fristedt, Gunnar Hedlund, Karl Jansson, Lisbeth Abramo, Ingela Fritzson, Olga Pekarski, Anna Runström, Helena Sandin, Ingela Thuvesson & Anders Björk. (2004) Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders:  Structure−Activity Relationship. Journal of Medicinal Chemistry 47:8, pages 2075-2088.
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Charlott Brunmark, Anna Runström, Lennart Ohlsson, Birgitta Sparre, Thomas Brodin, Mikael Åström & Gunnar Hedlund. (2002) The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 130:1-2, pages 163-172.
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L.-P. Zou, N. Abbas, I. Volkmann, I. Nennesmo, M. Levi, B. Wahren, B. Winblad, G. Hedlund & J. Zhu. (2002) Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue. Neuropharmacology 42:5, pages 731-739.
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Lisa L. Cook, Michael A. Persinger & Stanley A. Koren. (2000) Differential effects of low frequency, low intensity (<6 mG) nocturnal magnetic fields upon infiltration of mononuclear cells and numbers of mast cells in lewis rat brains. Toxicology Letters 118:1-2, pages 9-19.
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