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Autoimmunity Volume 28, 1998 - Issue 4
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Original Article

Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process

L. C. Gahringa Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) and University of Utah School of Medicine, Salt Lake City, UT, 84112, USA
,
N. G. Carlsona Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) and University of Utah School of Medicine, Salt Lake City, UT, 84112, USA
&
S. W. Rogersa Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) and University of Utah School of Medicine, Salt Lake City, UT, 84112, USACorrespondence[email protected]
Pages 243-248 | Received 19 Dec 1997, Published online: 07 Jul 2009

Citations (5)

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Read on this site (1)

Sarosh Irani & Bethan Lang. (2008) Autoantibody-mediated disorders of the central nervous system. Autoimmunity 41:1, pages 55-65.
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Articles from other publishers (4)

David Orain, Engin Tasdelen, Samuel Haessig, Manuel Koller, Anne Picard, Celine Dubois, Kurt Lingenhoehl, Sandrine Desrayaud, Phillip Floersheim, David Carcache, Stephan Urwyler, Joerg Kallen & Henri Mattes. (2016) Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist. ChemMedChem 12:3, pages 197-201.
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Mia Levite. (2014) GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. Journal of Neural Transmission 121:8, pages 1029-1075.
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Lorise C. Gahring, Noel G. Carlson, Erin L. Meyer, Emily L. Days & Scott W. Rogers. 2004. Molecular Insights into Ion Channel Biology in Health and Disease. Molecular Insights into Ion Channel Biology in Health and Disease 141 159 .
Gordon J. Lees. (2000) Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders. Drugs 59:1, pages 33-78.
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