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Original Article

Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process

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Pages 243-248 | Received 19 Dec 1997, Published online: 07 Jul 2009

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Sarosh Irani & Bethan Lang. (2008) Autoantibody-mediated disorders of the central nervous system. Autoimmunity 41:1, pages 55-65.
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Articles from other publishers (4)

David Orain, Engin Tasdelen, Samuel Haessig, Manuel Koller, Anne Picard, Celine Dubois, Kurt Lingenhoehl, Sandrine Desrayaud, Phillip Floersheim, David Carcache, Stephan Urwyler, Joerg Kallen & Henri Mattes. (2017) Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist. ChemMedChem 12:3, pages 197-201.
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Mia Levite. (2014) GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. Journal of Neural Transmission 121:8, pages 1029-1075.
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Lorise C. Gahring, Noel G. Carlson, Erin L. Meyer, Emily L. Days & Scott W. Rogers. 2004. Molecular Insights into Ion Channel Biology in Health and Disease. Molecular Insights into Ion Channel Biology in Health and Disease 141 159 .
Gordon J. Lees. (2000) Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders. Drugs 59:1, pages 33-78.
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