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Autoimmunity Volume 28, 1998 - Issue 4
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Original Article

Autoantigenic Reactivity of Diabetes Sera with a Hybrid Glutamic Acid Decarboxylase GAD67–65 Molecule GAD67(1–101)/GAD65(96–585)

K. L. Teohb Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260
,
S. Fidab Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260
,
M.J. Rowleya Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3168, AustraliaCorrespondence[email protected]
&
I. R. Mackaya Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3168, Australia
Pages 259-266 | Received 16 Jan 1998, Published online: 07 Jul 2009

Citations (16)

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N. Hayakawa, L.D.K.E. Premawardhana, M. Powell, M. Masuda, C. Arnold, J. Sanders, M. Evans, S. Chen, J.C. Jaume, S. Baekkeskov, B. Rees Smith & J. Furmaniak. (2002) Isolation and Characterization of Human Monoclonal Autoantibodies to Glutamic Acid Decarboxylase. Autoimmunity 35:5, pages 343-355.
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Articles from other publishers (15)

Matilde Merlin, Elisa Gecchele, Elsa Arcalis, Sabrina Remelli, Annalisa Brozzetti, Mario Pezzotti & Linda Avesani. (2016) Enhanced GAD65 production in plants using the MagnICON transient expression system: Optimization of upstream production and downstream processing. Biotechnology Journal 11:4, pages 542-553.
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Claude Nogues, Hervé Leh, Christopher G. Langendorf, Ruby H. P. Law, Ashley M. Buckle & Malcolm Buckle. (2010) Characterisation of Peptide Microarrays for Studying Antibody-Antigen Binding Using Surface Plasmon Resonance Imagery. PLoS ONE 5:8, pages e12152.
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Yasir Arafat, Gustavo Fenalti, James C. Whisstock, Ian R. Mackay, Maria Garcia de la Banda, Merrill J. Rowley & Ashley M. Buckle. (2009) Structural determinants of GAD antigenicity. Molecular Immunology 47:2-3, pages 493-505.
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S M Trigwell, P M Radford, S R Page, A C Loweth, R F L James, N G Morgan & I Todd. (2001) Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus. Clinical and Experimental Immunology 126:2, pages 242-249.
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Gustavo Fenalti, Christiane S. Hampe, Yasir Arafat, Ruby H.P. Law, J. Paul Banga, Ian R. Mackay, James C. Whisstock, Ashley M. Buckle & Merrill J. Rowley. (2008) COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity. Diabetes 57:5, pages 1293-1301.
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Gustavo Fenalti, Christiane S. Hampe, Karen O’Connor, J. Paul Banga, Ian R. Mackay, Merrill J. Rowley & Ossama El-Kabbani. (2007) Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11. Molecular Immunology 44:6, pages 1178-1189.
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Karen H. O'Connor, J. Paul Banga, Connie Darmanin, Ossama El-Kabbani, Ian R. Mackay & Merrill J. Rowley. (2006) Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling. Journal of Autoimmunity 26:3, pages 172-181.
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Katherine A. Binder, J. Paul Banga, Anne-Marie Madec, Eva Ortqvist, Dong Luo & Christiane S. Hampe. (2004) Epitope analysis of GAD65Ab using fusion proteins and rFab. Journal of Immunological Methods 295:1-2, pages 101-109.
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M.E Primo, E.A Anton, A.L Villanueva, E Poskus & M.R Ermácora. (2003) Engineered variants of human glutamic acid decarboxylase (GAD) and autoantibody epitope recognition. Clinical Immunology 108:1, pages 38-45.
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Sandra B. Martin, Robert A. Waniewski, Gino Battaglioli & David L. Martin. (2003) Post-mortem degradation of brain glutamate decarboxylase. Neurochemistry International 42:7, pages 549-554.
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Shahnaz Fida, Mark A. Myers, Senga Whittingham, Merrill J. Rowley, Shoichi Ozaki & Ian R. Mackay. (2002) Autoantibodies to the Transcriptional Factor SOX13 in Primary Biliary Cirrhosis Compared with Other Diseases. Journal of Autoimmunity 19:4, pages 251-257.
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Jonathan C Tong, Ian R Mackay, Judy Chin, Ruby H.P Law, Karine Fayad & Merrill J Rowley. (2002) Enzymatic characterization of a recombinant isoform hybrid of glutamic acid decarboxylase (rGAD67/65) expressed in yeast. Journal of Biotechnology 97:2, pages 183-190.
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Mark A. Myers, Janet M. Davies, Jonathan C. Tong, James Whisstock, Marita Scealy, Ian R. Mackay & Merrill J. Rowley. (2000) Conformational Epitopes on the Diabetes Autoantigen GAD65 Identified by Peptide Phage Display and Molecular Modeling. The Journal of Immunology 165:7, pages 3830-3838.
Crossref
T. Papakonstantinou, R.H.P. Law, P. Gardiner, M.J. Rowley & I.R. Mackay. (2000) Comparative expression and purification of human glutamic acid decarboxylase from Saccharomyces cerevisiae and Pichia pastoris. Enzyme and Microbial Technology 26:9-10, pages 645-652.
Crossref
Ruby H.P Law, Merrill J Rowley, Ian R Mackay & Brian Corner. (1998) Expression in Saccharomyces cerevisiae of antigenically and enzymatically active recombinant glutamic acid decarboxylase. Journal of Biotechnology 61:1, pages 57-68.
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