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Original Article

Autoimmune Diabetes: The Role of T Cells, MHC Molecules and Autoantigens

Pages 159-177 | Received 17 Feb 1997, Accepted 30 Jun 1997, Published online: 07 Jul 2009

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Muhammad Ilyas Y., Idin Sahidin, Asriullah Jabbar, Agung W. M. Yodha, Ajeng Diantini, Ivan Surya Pradipta, Riezki Amalia, Raden Maya Febrianti, Yuni Elsa Hadisaputri, Mohammad Ghozali & Euis Julaeha. (2023) Effect of Immunomodulating Extract and Some Isolates from Etlingera rubroloba A.D. Poulsen Fruits on Diabetic Patients with Tuberculosis. Molecules 28:5, pages 2401.
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Deepak KGK & Rama Rao Malla. 2019. Exploring Pancreatic Metabolism and Malignancy. Exploring Pancreatic Metabolism and Malignancy 237 251 .
Nadir Askenasy. (2015) Mechanisms of diabetic autoimmunity: I—the inductive interface between islets and the immune system at onset of inflammation. Immunologic Research 64:2, pages 360-368.
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Nadir Askenasy. (2015) Mechanisms of diabetic autoimmunity: II—Is diabetes a central or peripheral disorder of effector and regulatory cells?. Immunologic Research 64:1, pages 36-43.
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Gohar S. Manzar, Eun-Mi Kim, Pavana Rotti & Nicholas Zavazava. (2014) Skin deep: from dermal fibroblasts to pancreatic beta cells. Immunologic Research 59:1-3, pages 279-286.
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Adi Mor, Yoel Kloog, Gad Keren & Jacob George. (2009) Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. European Journal of Pharmacology 616:1-3, pages 301-305.
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Richard Kennedy & Esteban Celis. (2008) Multiple roles for CD4 + T cells in anti-tumor immune responses . Immunological Reviews 222:1, pages 129-144.
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D. G. Alleva, R. A. Maki, A. L. Putnam, J. M. Robinson, M. S. Kipnes, P. Dandona, J. B. Marks, D. L. Simmons, C. J. Greenbaum, R. G. Jimenez, P. J. Conlon & P. A. Gottlieb. (2006) Immunomodulation in Type 1 Diabetes by NBI-6024, an Altered Peptide Ligand of the Insulin B(9-23) Epitope. Scandinavian Journal of Immunology 63:1, pages 59-69.
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Michael J. Haller, Mark A. Atkinson & Desmond Schatz. (2005) Type 1 Diabetes Mellitus: Etiology, Presentation, and Management. Pediatric Clinics of North America 52:6, pages 1553-1578.
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Richard Kennedy, Anita H. Undale, William C. Kieper, Matthew S. Block, Larry R. Pease & Esteban Celis. (2005) Direct Cross-Priming by Th Lymphocytes Generates Memory Cytotoxic T Cell Responses. The Journal of Immunology 174:7, pages 3967-3977.
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Meng Huang, Kametra Matthews, Teruna J. Siahaan & Christopher G. Kevil. (2005) α L -Integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium . American Journal of Physiology-Gastrointestinal and Liver Physiology 288:1, pages G67-G73.
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Bernhard A Herzog, Patrick A Ott, Marcus T Dittrich, Stefan Quast, Alexey Y Karulin, Hubert Kalbacher, Wolfram Karges, Magdalena Tary-Lehmann, Paul V Lehmann, Bernhard O Boehm & Ivana Durinovic-Belló. (2004) Increased in vivo frequency of IA-2 peptide-reactive IFNγ+/IL-4− T cells in type 1 diabetic subjects. Journal of Autoimmunity 23:1, pages 45-54.
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IVANA DURINOVIC-BELLÓ, NICOLA MAISEL, MICHAEL SCHLOSSER, HUBERT KALBACHER, MARTIN DEEG, THOMAS EIERMANN, WOLFRAM KARGES & BERNHARD O. BOEHM. (2003) Relationship between T and B Cell Responses to Proinsulin in Human Type 1 Diabetes. Annals of the New York Academy of Sciences 1005:1, pages 288-294.
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RUIHUA PENG, Y. LI, K. BREZNER, SALLY LITHERLAND & M. J. CLARE-SALZLER. (2003) Abnormal Peripheral Blood Dendritic Cell Populations in Type 1 Diabetes. Annals of the New York Academy of Sciences 1005:1, pages 222-225.
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Bart O. Roep. (2003) The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure. Diabetologia 46:3, pages 305-321.
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Marie K. Brimnes, Teis Jensen, Trine N. Jørgensen, Birgitte K. Michelsen, Jesper Troelsen & Ole Werdelin. (2002) Low Expression of Insulin in the Thymus of Non-obese Diabetic Mice. Journal of Autoimmunity 19:4, pages 203-213.
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David G. Alleva, Amitabh Gaur, Liping Jin, Dale Wegmann, Peter A. Gottlieb, Anil Pahuja, Eric B. Johnson, Theresa Motheral, Amy Putnam, Paul D. Crowe, Nicholas Ling, Stefen A. Boehme & Paul J. Conlon. (2002) Immunological Characterization and Therapeutic Activity of an Altered-Peptide Ligand, NBI-6024, Based on the Immunodominant Type 1 Diabetes Autoantigen Insulin B-Chain (9–23) Peptide. Diabetes 51:7, pages 2126-2134.
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Carol L. Vanderlugt & Stephen D. Miller. (2002) Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nature Reviews Immunology 2:2, pages 85-95.
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Ivana Durinovic-Belló, Bernhard O. Boehm & Anette-G. Ziegler. (2002) Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity. Journal of Autoimmunity 18:1, pages 55-66.
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David G. Alleva, Paul D. Crowe, Liping Jin, William W. Kwok, Nicholas Ling, Michael Gottschalk, Paul J. Conlon, Peter A. Gottlieb, Amy L. Putnam & Amitabh Gaur. (2001) A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. Journal of Clinical Investigation 107:2, pages 173-180.
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Diane K Wherrett. (2001) Measurement of Soluble Adhesion Molecules: Can It Improve Diabetes Prediction?: Commentary on the article by Toivonen et al. on page 24. Pediatric Research 49:1, pages 5-7.
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. 2001. Dendritic Cells. Dendritic Cells 651 770 .
Ranjeny Thomas. 2001. Dendritic Cells. Dendritic Cells 459 cp1 .
Kathleen N. Potter & Terence J. Wilkin. (2000) The molecular specificity of insulin autoantibodies. Diabetes/Metabolism Research and Reviews 16:5, pages 338-353.
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