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Immunopharmacology and Immunotoxicology Volume 32, 2010 - Issue 1
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Research Article

Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms

Todd W. CostantiniDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, California
,
Jessica DereeDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, California
,
Carrie Y. PetersonDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, California
,
James G. PutnamDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, California
,
Tiffany WoonDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, California
,
William H. LoomisDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, California
,
Vishal BansalDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, California
&
Raul CoimbraDivision of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California-San Diego School of Medicine, San Diego, CaliforniaCorrespondence[email protected]
 show all
Pages 82-91 | Received 30 Jun 2009, Accepted 14 Jul 2009, Published online: 19 Oct 2009

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Gianni Paulis, Andrea Paulis, Gennaro Romano, Davide Barletta & Andrea Fabiani. (2017) Rationale of combination therapy with antioxidants in medical management of Peyronie’s disease: results of clinical application. Research and Reports in Urology 9, pages 129-139.
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Articles from other publishers (21)

Gianni Paulis, Giovanni De Giorgio & Luca Paulis. (2022) Role of Oxidative Stress in Peyronie’s Disease: Biochemical Evidence and Experiences of Treatment with Antioxidants. International Journal of Molecular Sciences 23:24, pages 15969.
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Gianni Paulis & Giovanni De Giorgio. (2022) Patients with Peyronie’s disease achieve complete plaque regression after multimodal treatment with antioxidants: a case series. Journal of Medical Case Reports 16:1.
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Mohammed Alorabi, Simona Cavalu, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Gomaa Mostafa-Hedeab, Walaa A. Negm, Amal Youssef, Aya H. El-Kadem, Hebatallah M. Saad & Gaber El-Saber Batiha. (2022) Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress. Biomedicine & Pharmacotherapy 152, pages 113225.
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Yuliya Filina, Aida Gabdoulkhakova, Albert Rizvanov & Valentina Safronova. (2022) MAP kinases in regulation of NOX activity stimulated through two types of formyl peptide receptors in murine bone marrow granulocytes. Cellular Signalling 90, pages 110205.
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Young-Duck Cho, Sung-Hyuk Choi, Sung-Jun Park, Jung-Youn Kim, Chae-Seung Lim, Woo-Sung Yu, Kim Kyung Hwan & Tae-Gun Shin. (2022) The impacts of oxygen and pentoxifylline in hypoxic condition. European Journal of Inflammation 20, pages 205873922110565.
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Alexandros Loukas Grammatis, Ektoras X Georgiou & Christian M Becker. (2021) Pentoxifylline for the treatment of endometriosis-associated pain and infertility  . Cochrane Database of Systematic Reviews 2021:8.
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Xiao‐Fang Zheng, Dan‐Dan Chen, Xiao‐Ling Zhu, Jehane Michael Le Grange, Lu‐Qian Zhou & Jin‐Nong Zhang. (2021) Impacts of anti‐inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation. Pharmacology Research & Perspectives 9:4.
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Hayrettin Ozturk, Ayhan Cetinkaya, Tulin Siviloglu Firat, Buket Kin Tekce, Selma Erdogan Duzcu & Hulya Ozturk. (2018) Protective effect of pentoxifylline on oxidative renal cell injury associated with renal crystal formation in a hyperoxaluric rat model. Urolithiasis 47:5, pages 415-424.
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Young-Duck Cho, Sung-Hyuk Choi, Young-Hoon Yoon, Jung-Youn Kim, Sung-Jun Park & Chae-Seung Lim. (2018) The Effects of Oxygen and Treatments in Hypoxic Conditions in SH-SY5Y Cells. Shock 50:4, pages 449-454.
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Bret H. Clough, Joni Ylostalo, Elizabeth Browder, Eoin P. McNeill, Thomas J. Bartosh, H. Ralph Rawls, Tetsuo Nakamoto & Carl A. Gregory. (2016) Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats. Calcified Tissue International 100:3, pages 298-310.
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Ondrej Cerny, Karen E. Anderson, Len R. Stephens, Phillip T. Hawkins & Peter Sebo. (2017) cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity. The Journal of Immunology 198:3, pages 1285-1296.
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M. Carmen Rodenas, Nicola Tamassia, Isabel Cabas, Federica Calzetti, José Meseguer, Marco A. Cassatella, Alfonsa García-Ayala & Victoriano Mulero. (2017) G Protein-Coupled Estrogen Receptor 1 Regulates Human Neutrophil Functions. Biomedicine Hub 2:1, pages 1-13.
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Gianni Paulis, Gennaro Romano, Luca Paulis & Davide Barletta. (2017) Recent Pathophysiological Aspects of Peyronie’s Disease: Role of Free Radicals, Rationale, and Therapeutic Implications for Antioxidant Treatment—Literature Review. Advances in Urology 2017, pages 1-17.
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Y.N. Lin, R. Jia, Y.H. Liu, Y. Gao, L.L. Wang, J.P. Kou & B.Y. Yu. (2015) Ruscogenin suppresses mouse neutrophil activation: Involvement of protein kinase A pathway. The Journal of Steroid Biochemistry and Molecular Biology 154, pages 85-93.
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SHI-KUN YANG, SHAO-BIN DUAN, PENG PAN, XIANG-QING XU, NA LIU & JUN XU. (2015) Preventive effect of pentoxifylline on contrast-induced acute kidney injury in hypercholesterolemic rats. Experimental and Therapeutic Medicine 9:2, pages 384-388.
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Franziska M. Konrad, Gianna Neudeck, Irene Vollmer, Kristian C. Ngamsri, Manfred Thiel & Jörg Reutershan. (2013) Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A 2A dependent . The FASEB Journal 27:9, pages 3524-3535.
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Hsin-Yi Lin & Jing-Huei Chen. (2013) Osteoblast differentiation and phenotype expressions on chitosan-coated Ti-6Al-4V. Carbohydrate Polymers 97:2, pages 618-626.
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TZOU-CHI HUANG, JEN-YU CHANG, HUNG-JEN LIU, SHINN-SHYONG TSAI, TSUNG-CHOU CHANG, CHI-TANG HO & KUO PIN CHUANG. (2013) ERIODICTYOL DECREASES REACTIVE OXYGEN SPECIES PRODUCTION AND INHIBITS P47 PHOX CLUSTERING AND TRANSLOCATION IN MONOCYTES . Journal of Food Biochemistry 37:4, pages 418-424.
Crossref
Irena Brunskole Hummel, Michael T. Reinartz, Solveig Kälble, Heike Burhenne, Frank Schwede, Armin Buschauer & Roland Seifert. (2013) Dissociations in the Effects of β2-Adrenergic Receptor Agonists on cAMP Formation and Superoxide Production in Human Neutrophils: Support for the Concept of Functional Selectivity. PLoS ONE 8:5, pages e64556.
Crossref
Di Zhang, Huiqing Jiang, Yan Wang & Junji Ma. (2012) Pentoxifylline inhibits hepatic stellate cells proliferation via the R af/ ERK pathway . APMIS 120:7, pages 572-581.
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Hung-Chi Yang, Mei-Ling Cheng, Hung-Yao Ho & Daniel Tsun-Yee Chiu. (2011) The microbicidal and cytoregulatory roles of NADPH oxidases. Microbes and Infection 13:2, pages 109-120.
Crossref

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