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Immunopharmacology and Immunotoxicology Volume 33, 2011 - Issue 4
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Original Article

Emodin-induced microglial apoptosis is associated with TRB3 induction

Xueping ZhouThe Clinical Research Institute, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China
,
Lili WangDepartment of Rehabilitation, University of California Los Angeles, California, USA
,
Mingyan WangDepartment of Biochemistry, College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing, China
,
Li XuDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
,
Li YuDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
,
Taihui FangDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
&
Mianhua WuThe Clinical Research Institute, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaCorrespondence[email protected]
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Pages 594-602 | Received 31 Aug 2010, Accepted 15 Dec 2010, Published online: 29 Jan 2011

Citations (20)

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Kenneth Maiese, Zhao Zhong Chong, Yan Chen Shang & Shaohui Wang. (2012) Targeting disease through novel pathways of apoptosis and autophagy. Expert Opinion on Therapeutic Targets 16:12, pages 1203-1214.
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Articles from other publishers (19)

Ahsas Goyal, Yogesh Murti, Bharat Bhushan, Wasim Chisti & Ashutosh Solanki. (2023) A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders. Current Drug Targets 24:12, pages 945-958.
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Chenyang Gu, Qiankun Zhang, Yajing Li, Rong Li, Jia Feng, Wanghao Chen, Waqas Ahmed, Ismatullah Soufiany, Shiying Huang, Jun Long & Lukui Chen. (2022) The PI3K/AKT Pathway—The Potential Key Mechanisms of Traditional Chinese Medicine for Stroke. Frontiers in Medicine 9.
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Saikat Mitra, Juhaer Anjum, Maniza Muni, Rajib Das, Abdur Rauf, Fahadul Islam, Talha Bin Emran, Prabhakar Semwal, Hassan A. Hemeg, Fahad A. Alhumaydhi & Polrat Wilairatana. (2022) Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action. Biomedicine & Pharmacotherapy 149, pages 112877.
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Man Luo, Wei Sun, Bin Zhou & Xiangqing Kong. (2022) Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway. Annals of Anatomy - Anatomischer Anzeiger 240, pages 151885.
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Rui-Pei Yang, Da-Ke Cai, Yu-Xing Chen, Hai-Ning Gang, Mei Wei, De-Quan Zhu, Su-Mei Li, Jiu-Mei Yang, Si-Ni Luo, Xiao-Li Bi & Dong-Mei Sun. (2021) Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics. Frontiers in Pharmacology 12.
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Xiaofei Zhu, Zhiyong Long, Tingting Bao, Liang Liu & Kailin Yang. (2021) Exploring the mechanism of Radix Rhei Et Rhizome intervention in intracerebral hemorrhage based on systematic pharmacology and proteomics strategy . Bioscience Reports 41:3.
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Stephen Wan Leung, Jing Huei Lai, John Chung-Che Wu, Yan-Rou Tsai, Yen-Hua Chen, Shuo-Jhen Kang, Yung-Hsiao Chiang, Cheng-Fu Chang & Kai-Yun Chen. (2020) Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway. International Journal of Molecular Sciences 21:8, pages 2899.
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Huizhen Zhao, Demin Gao & Xiaoyan Gao. (2019) Rhubarb ameliorates cognitive dysfunction in a rat model of Alzheimer's disease through regulation of the intestinal microbiome. Journal of Traditional Chinese Medical Sciences 6:3, pages 234-243.
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Xun Li, Shifeng Chu, Yinjiao Liu & Naihong Chen. (2019) Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-12.
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Liying Yang, Yingying Zhang, Zhongrui Yan & Feng Tian. (2017) The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion. Experimental and Therapeutic Medicine 14:4, pages 2839-2844.
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Xiaoxv Dong, Jing Fu, Xingbin Yin, Sali Cao, Xuechun Li, Longfei Lin & Jian Ni. (2016) Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics. Phytotherapy Research 30:8, pages 1207-1218.
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YANG WANG, FAN PENG, GUI XIE, ZE-QI CHEN, HAI-GANG LI, TAO TANG & JIE-KUN LUO. (2016) Rhubarb attenuates blood-brain barrier disruption via increased zonula occludens-1 expression in a rat model of intracerebral hemorrhage. Experimental and Therapeutic Medicine 12:1, pages 250-256.
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Sung Min Ahn, Ha Neui Kim, Yu Ri Kim, Young Whan Choi, Cheol Min Kim, Hwa Kyoung Shin & Byung Tae Choi. (2016) Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia. Journal of Ethnopharmacology 188, pages 13-20.
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Wen-Pin Cheng, Bao-Wei Wang, Huey-Ming Lo & Kou-Gi Shyu. (2015) Mechanical Stretch Induces Apoptosis Regulator TRB3 in Cultured Cardiomyocytes and Volume-Overloaded Heart. PLOS ONE 10:4, pages e0123235.
Crossref
T C Jackson, J D Verrier & P M Kochanek. (2013) Anthraquinone-2-sulfonic acid (AQ2S) is A Novel Neurotherapeutic Agent. Cell Death & Disease 4:1, pages e451-e451.
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Zhao Zhong Chong, Yan Chen Shang, Shaohui Wang & Kenneth Maiese. (2012) Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin. Progress in Neurobiology 99:2, pages 128-148.
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Kenneth Maiese, Zhao Chong, Shaohui Wang & Yan Shang. (2012) Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade. International Journal of Molecular Sciences 13:12, pages 13830-13866.
Crossref
Kenneth Maiese, Zhao Zhong Chong, Yan Chen Shang & Shaohui Wang. (2012) Erythropoietin: New Directions for the Nervous System. International Journal of Molecular Sciences 13:9, pages 11102-11129.
Crossref
Shu-Chun Hsu & Jing-Gung Chung. (2012) Anticancer potential of emodin. BioMedicine 2:3, pages 108-116.
Crossref

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