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Immunopharmacology and Immunotoxicology Volume 33, 2011 - Issue 4
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Original Article

Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation

Beom-Joon LeeDepartment of Internal Medicine, Kangnam Korean Hospital, Kyung Hee University, Seoul, South Korea
,
Youn-Jung KimCollege of Nursing Science, East-West Nursing Institute, Kyung Hee University, Seoul, South Korea
,
Dong-Hyung ChoDepartment of East-West Medical Science, Graduate School of Kyung Hee University, Yongin, South Korea
,
Nak-Won SohnDepartment of East-West Medical Science, Graduate School of Kyung Hee University, Yongin, South Korea
&
Hee KangDepartment of East-West Medical Science, Graduate School of Kyung Hee University, Yongin, South KoreaCorrespondence[email protected]
Pages 714-722 | Received 31 Oct 2010, Accepted 15 Feb 2011, Published online: 29 Mar 2011

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Farideh Shishehbor, Mahnaz Rezaeyan Safar, Elham Rajaei & Mohammad Hosein Haghighizadeh. (2018) Cinnamon Consumption Improves Clinical Symptoms and Inflammatory Markers in Women With Rheumatoid Arthritis. Journal of the American College of Nutrition 37:8, pages 685-690.
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M. Saeed, A.A. Kamboh, S.F. Syed, D. Babazadeh, I. Suheryani, Q.A. Shah, M. Umar, I. Kakar, M. Naveed, M.E. Abd El-Hack, M. Alagawany & S. Chao. (2018) Phytochemistry and beneficial impacts of cinnamon (Cinnamomum zeylanicum) as a dietary supplement in poultry diets. World's Poultry Science Journal 74:2, pages 331-346.
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Articles from other publishers (32)

Xiao-lei Zhang, Callie M. Hollander, Mohammad Yasir Khan, Melinee D’silva, Haoqin Ma, Xinyuan Yang, Robin Bai, Coles K. Keeter, Elena V. Galkina, Jerry L. Nadler & Patric K. Stanton. (2023) Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet. Communications Biology 6:1.
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Shubrata Khedkar & Minhaj Ahmad Khan. (2023) Aqueous Extract of Cinnamon (Cinnamomum spp.): Role in Cancer and Inflammation. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-20.
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Nidhi Singh. 2023. COVID-19: Origin, Impact and Management (Part 2). COVID-19: Origin, Impact and Management (Part 2) 145 164 .
Zhiyong Long, Wang Xiang, Qi He, Wei Xiao, Huagen Wei, Hao Li, Hua Guo, Yuling Chen, Mengxia Yuan, Xiao Yuan, Liuting Zeng, Kailin Yang, Yuxuan Deng & Zhen Huang. (2023) Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials. Frontiers in Immunology 14.
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Deepika Saini, Kumud Madan & Shilpi Chauhan. (2022) Screening of Phytoconstituents from Traditional Plants against SARSCoV- 2 using Molecular Docking Approach. Letters in Drug Design & Discovery 19:11, pages 1022-1038.
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Maria Bibiana Zapata Londoño, Diego Fernando Uribe Yunda, Johanny Aguillón Osma & Maria Elena Maldonado‐Celis. 2022. Molecular Mechanisms of Functional Food. Molecular Mechanisms of Functional Food 404 430 .
Rui‐Qing Wu, Peng Wen, Teng‐Gen Hu & Hong Wu. (2022) Extracts from Cinnamomum cassia leaf residues display antioxidant and anti‐inflammatory activities . Journal of Food Processing and Preservation 46:4.
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Shankar Gautam, Arun Gautam, Sahanshila Chhetri & Urza Bhattarai. (2022) Immunity against COVID-19: Potential role of Ayush Kwath. Journal of Ayurveda and Integrative Medicine 13:1, pages 100350.
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Mohd Fadhlizil Fasihi Mohd Aluwi, A.K.M. Moyeenul Huq & Md Akil Hossain. 2022. Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health. Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health 209 217 .
Monalisha Karmakar, Debarati Jana, Tuhin Manna, Avijit Banik, Priyanka Raul, Kartik Chandra Guchhait, Keshab Chandra Mondal, Amiya Kumar Panda & Chandradipa Ghosh. 2022. Plants and Phytomolecules for Immunomodulation. Plants and Phytomolecules for Immunomodulation 191 249 .
Ajaikumar B. Kunnumakkara, Varsha Rana, Dey Parama, Kishore Banik, Sosmitha Girisa, Sahu Henamayee, Krishan Kumar Thakur, Uma Dutta, Prachi Garodia, Subash C. Gupta & Bharat B. Aggarwal. (2021) COVID-19, cytokines, inflammation, and spices: How are they related?. Life Sciences 284, pages 119201.
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Visweswara Rao Pasupuleti. 2021. Bioactive Compounds in Underutilized Vegetables and Legumes. Bioactive Compounds in Underutilized Vegetables and Legumes 443 452 .
Visweswara Rao Pasupuleti. 2020. Bioactive Compounds in Underutilized Vegetables and Legumes. Bioactive Compounds in Underutilized Vegetables and Legumes 1 10 .
Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi, Shehwaz Anwar, Amit Kumar Verma, Kapil Dev & Arshad Husain Rahmani. (2020) Cinnamon and its active compounds: A potential candidate in disease and tumour management through modulating various genes activity. Gene Reports 21, pages 100966.
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G. A. S. Premakumara & W. P. K. M. Abeysekera. 2020. Cinnamon. Cinnamon 307 325 .
Milad Ashrafizadeh, Zahra Ahmadi, Niranjan G. Kotla, Elham Ghasemipour Afshar, Saeed Samarghandian, Ali Mandegary, Abbas Pardakhty, Reza Mohammadinejad & Gautam Sethi. (2019) Nanoparticles Targeting STATs in Cancer Therapy. Cells 8:10, pages 1158.
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Natalia Vallianou, Catherine Tsang, Mohsen Taghizadeh, Amirhossein Davoodvandi & Sadegh Jafarnejad. (2019) Effect of cinnamon (Cinnamomum Zeylanicum) supplementation on serum C-reactive protein concentrations: A meta-analysis and systematic review. Complementary Therapies in Medicine 42, pages 271-278.
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Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti & Bharat B. Aggarwal. (2018) Chronic diseases, inflammation, and spices: how are they linked?. Journal of Translational Medicine 16:1.
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Jong-In Kim, Ju-Hoon Lee, Youngju Song, You-Tae Kim, Youn-Hyung Lee & Hee Kang. (2018) Oral consumption of cinnamon enhances the expression of immunity and lipid absorption genes in the small intestinal epithelium and alters the gut microbiota in normal mice. Journal of Functional Foods 49, pages 96-104.
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Samah K. Ezzat, Mazen T. AbuElkhair, Mohamed I. Mourad, Mohamed E. Helal & Mohammed E. Grawish. (2017) Effects of aqueous cinnamon extract on chemically-induced carcinoma of hamster cheek pouch mucosa. Biochemistry and Biophysics Reports 12, pages 72-78.
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R. Goswami & M.H. Kaplan. 2017. 123 180 .
Malgorzata Szelag, Anna Piaszyk-Borychowska, Martyna Plens-Galaska, Joanna Wesoly & Hans A.R. Bluyssen. (2016) Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease. Oncotarget 7:30, pages 48788-48812.
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Deniz Hancı, Hüseyin Altun, Erdem Atalay Çetinkaya, Nuray Bayar Muluk, Betül Peker Cengiz & Cemal Cingi. (2016) Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis in a rat model. International Journal of Pediatric Otorhinolaryngology 84, pages 81-87.
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Mitra Hariri & Reza Ghiasvand. 2016. Drug Discovery from Mother Nature. Drug Discovery from Mother Nature 1 24 .
Wei-Ling Lin, Shih-Yun Guu, Chan-Chuan Tsai, Ekambaranellore Prakash, Mohan Viswaraman, Hsing-Bao Chen & Chuan-Fa Chang. (2015) Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides. PLOS ONE 10:6, pages e0130389.
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Kiran S. Panickar. 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease 3 15 .
Hee Kang, Sung-Hyun Park, Jeong-Moon Yun, Tae-Gyu Nam, Young-Eun Kim, Dae-Ok Kim & Youn Jung Kim. (2014) Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity. BMC Complementary and Alternative Medicine 14:1.
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Nathalie Marissal-Arvy, Cécile Batandier, Julien Dallennes, Frédéric Canini, Laurent Poulet, Karine Couturier, Isabelle Hininger-Favier, Marie-Pierre Moisan, Anne-Marie Roussel & Pierre Mormède. (2013) Effect of a high-fat–high-fructose diet, stress and cinnamon on central expression of genes related to immune system, hypothalamic–pituitary–adrenocortical axis function and cerebral plasticity in rats. British Journal of Nutrition 111:7, pages 1190-1201.
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Liang Chen, Yang Yang, Pulong Yuan, Yifu Yang, Kaixian Chen, Qi Jia & Yiming Li. (2014) Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala . Evidence-Based Complementary and Alternative Medicine 2014, pages 1-9.
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Gabriella Miklossy, Tyvette S. Hilliard & James Turkson. (2013) Therapeutic modulators of STAT signalling for human diseases. Nature Reviews Drug Discovery 12:8, pages 611-629.
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Joung-Woo Hong, Ga-Eun Yang, Yoon Bum Kim, Seok Hyun Eom, Jae-Hwan Lew & Hee Kang. (2012) Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models. BMC Complementary and Alternative Medicine 12:1.
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Denys J. CharlesDenys J. Charles. 2013. Antioxidant Properties of Spices, Herbs and Other Sources. Antioxidant Properties of Spices, Herbs and Other Sources 231 243 .

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